Thiamine and Pyridoxine Loaded Vanillic Acid Grafted Chitosan Modulates Lactate and Malate Dehydrogenase in Albino Rats

Abstract

Feeding trials was conducted to study the response
of metabolic enzymes activity such as lactate
dehydrogenase (LDH) and malate dehydrogenase
(MDH) through dietary supplementation of thiamine
and pyridoxine loaded vanillic acid grafted
chitosan microparticles (TPVGC) in male and female
Wistar strain albino rats for a period of 45 days.
Forty-eight animals both male and female were
randomly distributed into eight experimental groups
and were fed with basal feed along with different
levels of TPVGC. At the end of the experiment, the
LDH activity in both male and female Wistar strain
albino rats were found to be significantly higher
(p<0.05) in the control groups and found to decrease
with the increase in the inclusion level of dietary
TPVGC in the diet. MDH activity was significantly
(p<0.05) reduced only in case of female rats. The
results obtained in present study shows that dietary
supplementation of TPVGC at a level of 0.8% could
uphold better metabolic homeostasis of lactate
dehydrogenase and malate dehydrogenase.