Histopathological Observaions on the Protective Effect of Vitamin E in Sodium Fluoride Induced Hepato-Renal Toxicity

Abstract

The sodium fluoride is toxic at long term exposure and leads to some adverse effects on vital organs. The objective of this study was to investigate the propensity of Sodium fluoride to induce pathological effect and its possible protection by Vitamin E in rats. Rats were divided into four groups. Group I was used as control and groups II, III and IV were orally treated with Sodium fluoride (8 mg/kg body weight), Vitamin E (100 mg/kg body weight) and
Sodium fluoride plus Vitamin E, respectively for 45days. Rats were sacrificed at the end of 45 days of experimentation. The pathological changes observed at necropsy were congestion in liver, and kidney. The histopathological lesions represented distended sinusoids with hyperplasia of kupffer cells in liver. Degenerative changes in the renal tubules were characterized by swelling of the lining epithelial cells. Almost similar lesions were recorded in the rats of sodium fluoride plus Vitamin E treated group but of very mild nature. Thus it is concluded that presence Vitamin E could diminish the ill effects of Sodium fluoride.