Exploring Indian wheat genotypes for less Celiac disease toxic epitopes
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Authors
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Sneh Narwal
ICAR-Indian Institute of Wheat and Barley Research
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Bunty Sharma
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Ritu saini
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Ram Baran Singh
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Om Prakash Gupta
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Vanita Pandey
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Sewa Ram
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Gyanendra Pratap Singh
Keywords:
Celiac disease, Wheat, Toxicity, GliadinsAbstract
The conflicting results on the immunogenicity of ancient
and modern wheat varieties highlights the need to
screen the large wheat germplasm available including
different wheat species, wild relatives and synthetics.
The identified genotypes with low CD toxicity can be
used in breeding programmes for reducing CD toxic
epitopes in high yielding varieties. This study is a very
small initiative where only one monoclonal antibody
against few epitopes has been used. More monoclonal
antibodies can be used in future studiesto target more
CD toxic epitopes.The most important challenge while
developing a new genotype with low CD toxicity either
by breeding or genetic engineering will be to keep the
baking and processing quality of the wheat intact.This
will bring less CD toxic wheat products in food chain with
consequences of reduced celiac disease
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