INCIDENCE OF MATURITY ONSET DIABETES OF THE YOUNG (MODY) AMONG THE SELECTED YOUNG ADULTS
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Keywords:
Diabetes,Gene Variation, Identification, Maturity Onset Diabetes of the Young (MODY)Abstract
This study investigated the incidence of maturity onset diabetes of the young (MODY) among young adults aged 18-35 years in Thoothukudi City, Tamil Nadu in the year 2021. Data was collected with the help of a well-structured interview schedule among 506 young adult participants. Four of the 506 participants, who met the MODY parameters (BMI below 30, two to three generations with diabetes, age below 35) were proceeded with additional genetic testing. Among the four, two were reported to have genetic mutations. One of the participants had a type 2 diabetes gene variation (AKT2 gene) and another had a MODY gene variation (KLF11 gene). Both Participants had a strong paternal side family history with diabetes and parents with diabetes. It indicates that having a strong family history of diabetes increases the likelihood that MODY and other kinds of diabetes will develop through heredity by some percent chance. The overall significance of this study is that it highlights the importance of early and accurate diagnosis for better treatment and management of this type of diabetes and also contributes to the spreading of knowledge on MODY
References
Abdulaziz Alrashed, F., Ahmad, T., Almurdi, M.
M., Alqahtani, A. S., Alamam, D. M and
Alsubiheen, A. M. 2023. Investigating the
relationship between lifestyle factors,
family history, and diabetes mellitus in
non-diabetic visitors to primary care
centers. Saudi Journal of Biological
Sciences, 30(9). https://doi.org/10.1016/
j.sjbs.2023.103777.
American Diabetes Association. 2022.
Diabetes Overview-Understanding A1C
Diagnosis. American Diabetes
Association (ADA). Retrieved from the
website (https://www.diabetes.org/
diabetes/a1c/diagnosis) on 24.07.2022.
Asgarian, S., Lanjanian, H., Rahimipour
Anaraki, S., Hadaegh, F., Moazzam-Jazi,
M., Najd-Hassan-Bonab, L., Masjoudi, S.,
Zahedi, A. S., Zarkesh, M., Shalbafan, B.,
Akbarzadeh, M., Tehrani Fateh, S.,
Khalili, D., Momenan, A., Sarbazi, N.,
Hedayati, M., Azizi, F and Daneshpour,
M. S. 2024. Examining the clinical and
genetic spectrum of maturity-onset
diabetes of the young (MODY) in Iran.
Scientific Reports, 14(1). https://doi.org/
10.1038/s41598-024-70864-y.
Belhiba, O., Aadam, Z., Jeddane, L., Saile, R.,
Salih Alj, H., Bousfiha, A. A and Jennane,
F. 2020. Research of anti-gad and anti
ia2 autoantibodies by elisa test in a
series of moroccanpediatric patients with
diabetes type 1. African Health Sciences,
20(3), 1337–1343. https://doi.org/
10.4314/ahs.v20i3.40.
Centers for Disease Control and Prevention.
2022. Family Health History and
Diabetes. National Center on Birth
Defects and Developmental Disabilities,
Office of Genomics and Precision Public
Health. https://www.cdc.gov/genomics/
famhistory/famhist_diabetes.html.
Delvecchio, M., Pastore, C and Giordano, P.
2020. Treatment Options for MODY
Patients: A Systematic Review of
Literature. Diabetes Therapy, 11, 1667
1685. https://doi.org/10.6084/
m9.figshare.12465173.
International Institute for Population Sciences
(IIPS) and Macro International. 2017.
National Family Health Survey (NFHS
4) 2015-16 India. Retrieved from the
website (http://www.rchiips.org/nfhs) on
08.09.2024.
Jamila, Fatema, Prity and Bhagat, S. 2017.
Gradual Decline of Joint Family System
in the Urban Area: A Study in Patna Town.
Explore-Journal of Research, 9, 220
226.
Kant, R., Davis, A and Verma, V. 2022. Maturity
Onset Diabetes of the Young: Rapid
Evidence Review. American Family
Physician, 105(2), 162–167.
Liu J, Li SB, Luo X, Yuan L, Lai YR, Zhang LL.
2023. Type 2 Diabetes and
Hyperlipidemia Caused by AKT2 Gene
Combined with PLIN1 Gene Mutation: A
Case Report. Biomedical and
Environmental Sciences, 36(4), 371
bes2023.043.
Maiti, S., Akhtar, S., Upadhyay, A. K and
Mohanty, S. K. 2023. Socioeconomic
inequality in awareness, treatment and
control of diabetes among adults in
India: Evidence from National Family
Health Survey of India (NFHS), 2019
2021. Scientific Reports, 13(1). https://
doi.org/10.1038/s41598-023-29978-y.
68
Leelavathi et al.,
Moonesinghe, R., Beckles, G. L. A., Liu, T and
Khoury, M. J. 2018. The contribution of
family history to the burden of diagnosed
diabetes, undiagnosed diabetes, and
prediabetes in the United States: analysis
of the National Health and Nutrition
Examination Survey, 2009–2014.
Genetics in Medicine, 20(10), 1159
1166. https://doi.org/10.1038/
gim.2017.238.
National Institute of Nutrition. 2020. NIN report
on nutrient Ideal body weight of Indian.
Retrieved from the website (https://
www.nin.res.in/news/paper7.pdf) on
27.04.2023.
Naylor, R., Knight Johnson, A., Del Gaudio, D.,
Adam, M. P., Ardinger, H. H and Pagon,
R. A. 2018. Maturity-Onset Diabetes of
the Young Overview. GeneReviews®
[Internet]. Seattle (WA): University of
Washington, Seattle; 1993-2018.
Negi, Jand Nambiar, D. 2021. Intersectional
social-economic inequalities in breast
cancer screening in India: analysis of the
National Family Health Survey. BMC
Women’s Health, 21(1). https://doi.org/
10.1186/s12905-021-01464-5.
Sarkar, R and Samanta, G. 2023 Local
Economy as the Key Driver of
Urbanization in the Indian Sundarbans.
Environment and Urbanization ASIA,
14(2), 203–217. https://doi.org/10.1177/
09754253231193124.
Singh, M., Shekhar, C and Shri, N. 2023.
Patterns in age at first marriage and its
determinants in India: A historical
perspective of last 30 years (1992–2021).
SSM - Population Health, 22. https://
doi.org/10.1016/j.ssmph.2023.101363.
Sun, Y., Qu, J., Wang, J., Zhao, R., Wang, C.,
Chen, L and Hou, X. 2021. Clinical and
Functional Characteristics of a Novel
KLF11 Cys354Phe Variant Involved in
Maturity-Onset Diabetes of the Young.
Journal of Diabetes Research, 2021.
https://doi.org/10.1155/2021/7136869
Urakami, T. 2019. Maturity-onset diabetes of
the young (MODY): Current perspectives
on diagnosis and treatment. Diabetes,
Metabolic Syndrome and Obesity, 12,
1047–1056. https://doi.org/10.2147/
DMSO.S179793.
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