Effect of systemic inflammatory response syndrome (SIRS) on prostaglandin metabolite and oxidative stress in canine pyometra

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  • L KIPJEN SINGH ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • M K PATRA ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • G K MISHRA ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • A C SAXENA ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • U K DE ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • S K SINGH ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • H KUMAR ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • N KRISHNASWAMY ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India



Dog, PGFM, Pyometra, SIRS


Pyometra, either open or closed cervix, inevitably progresses to systemic inflammatory response syndrome (SIRS), if ovariohysterectomy is not done timely. The aim of the study was to investigate the effect of pyometra led SIRS on certain serum biochemical and prostaglandin metabolite, 13,14-dihydro-15-keto PGF2 alpha (PGFM) and oxidative stress indices in the canine. The pyometra positive bitches were categorized as SIRS+ (n=29) and SIRS- (n =16) based on temperature (<100.5 or >102.5°F), respiration rate (>20/min), heart rate (>102/min), and total leukocytes count (<6×103 or >16×103 per μL). The SIRS+ bitches showed hypoalbuminemia, hyperglobulinemia, elevated blood urea nitrogen and creatinine, decreased super oxide dismutase (SOD) activity with moderate increase in the lipid peroxidation. Further, the SIRS+ bitches had significantly higher serum PGFM concentration (6.83±0.7 vs. 4.12±0.4 ng/mL) than SIRS- and the level was influenced by cervical patency. It was concluded that elevated serum PGFM along with hyperglobunemia, blood urea nitrogen, creatinine would be useful in diagnosis and monitoring of pyometra led SIRS in bitch.


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How to Cite

SINGH, L. K., PATRA, M. K., MISHRA, G. K., SAXENA, A. C., DE, U. K., SINGH, S. K., KUMAR, H., & KRISHNASWAMY, N. (2020). Effect of systemic inflammatory response syndrome (SIRS) on prostaglandin metabolite and oxidative stress in canine pyometra. The Indian Journal of Animal Sciences, 90(4), 569-573. https://doi.org/10.56093/ijans.v90i4.104199