Haematological and biochemical profiling of Ladakhi cow: A native cattle of high altitude Leh-Ladakh, India

PREETI KUMARI; VIJAY K BHARTI; DEEPAK KUMAR; MANISHI MUKESH; INDU SHARMA

doi:10.56093/ijans.v90i4.104210

Authors

PREETI KUMARI DRDO-Defence Institute of High Altitude Research, Leh-Ladakh, Ladakh 194 101 India
VIJAY K BHARTI DRDO-Defence Institute of High Altitude Research, Leh-Ladakh, Ladakh 194 101 India
DEEPAK KUMAR DRDO-Defence Institute of High Altitude Research, Leh-Ladakh, Ladakh 194 101 India
MANISHI MUKESH DRDO-Defence Institute of High Altitude Research, Leh-Ladakh, Ladakh 194 101 India
INDU SHARMA DRDO-Defence Institute of High Altitude Research, Leh-Ladakh, Ladakh 194 101 India

https://doi.org/10.56093/ijans.v90i4.104210

Keywords:

Biochemical, Body-measurements, Haematology, High altitude, Ladakhi cow

Abstract

Ladakhi cattle is a native breed of cattle which is well adapted to hypobaric-hypoxia and cold-stress conditions prevalent at high altitude. These cattle are the main source of A2 quality milk. However, their utility, health and dairy production managements were not standardised for optimum dairy farm economics. Moreover, the haematological and biochemical parameters have not been investigated in details in adult Ladakhi cows, which is the primary requirement of farm health managements. Thus, the objective of this study was to examine the haematology and biochemical parameters in adult Ladakhi cow to establish baseline reference values. Clinically healthy female Ladakhi cattle (10) were selected from the Ladakhi cattle research section, DIHAR, Leh. The resulted haematological and biochemical parameters were compared with already reported reference values for low lander cattle and high lander native and crossbred cattle. Haematological findings revealed that RBC, Hb, heamatocrit, MCV and WBC were within the reference range, rather MCH and MCHC values were more than the reference range. Biochemical findings revealed that albumin, glucose, creatinine, uric acid, alkaline phosphatase, and aspartate aminotransferase were within the reference range limits of low lander. However, urea, triglycerides, total protein values were higher than the reference range and calcium was less than the reference range. These findings indicated that the native Ladakhi cattle are in healthy condition and metabolically adapted to high altitude stress. Hence, these hemato-biochemical profile could be the good biomarkers to evaluate their health status in high altitude stress condition.

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References

Ahmed I, Gohar A, Ahmed N and Ahmed M. 2009. Haematological profile in cyclic and non-cyclic and endometritic crossbreed cattle. International Journal of Agriculture and Biology 27: 83–91.

Ash P, Haynes L, Pond C, Robinson D and Harding R. 2004. Environmental Physiology-Altitude. Aden group, pp. 215–219. (Ed.) Harding R. Open University, Oxford, UK. Chapter 6.5.

Bharti V K, Giri A, Vivek P and Kalia S. 2017. Health and productivity of dairy cattle in high altitude cold desert environment of Leh-Ladakh: A review. Indian Journal of Animal Sciences 87: 3–10.

Doxey D L. 1983. Clinical Pathology and Diagnostic Procedures. Balliere Tindall. 2 edn. Eastbourne, UK.

El–Nouty F D, Al–Haidary A A and Salah M S. 1990. Seasonal variation in haematological values of high and average yielding Holstein cattle in semi-arid environment. Journal of King Saudi University 2: 173–82.

Giri A, Bharti V K, Kalia S, Ravindran T V, Ranjan P, Kundan T R and Kumar B. 2017. Seasonal changes in haematological and biochemical profile of dairy cows at high altitude cold desert. Indian Journal of Animal Sciences 87: 723–27.

Higgins C. 2016. Urea and the clinical value of measuring blood urea concentration. www.acutecaretesting.org.

Imoberdorf R, Garlick P J, Mcnurlan M A, Casella G A, Peheim E, Turgay M, Bartsch P and Ballmer P E. 2001. Enhanced synthesis of albumin and fibrinogen at high altitude. Journal of Applied Physiology 90: 528–37. DOI: https://doi.org/10.1152/jappl.2001.90.2.528

Jain N C. 1993. Essentials of Veterinary Nematology. Lea & Febiger, Philadelphia 1–18.

Kaneko J J, Harvey J W and Bruss M L. 2008. Clinical Biochemistry of Domestic Animals. Academic Press. 6 edn. pp. 45–620. USA. DOI: https://doi.org/10.1016/B978-0-12-370491-7.00003-9

Kumar B and Pachaura S P. 2000. Haematological profile of crossbred dairy cattle to monitor herd health status at medium elevation in central Himalayas. Research in Veterinary Science 69: 141–45. DOI: https://doi.org/10.1053/rvsc.2000.0400

Latimer K S, Duncan and Prasse. 2011. Veterinary Laboratory Medicine: Clinical Pathology. Wiley-Blackwell. 5 edn. pp. 1– 365. Athens, Georgia.

Mamun M A, Hassan M M, Shaikat A H, Islam S K M A, Hoque M A, Uddin M and Hossain M B. 2013. Biochemical analysis of blood of native cattle in the hilly area of Bangladesh. Bangladesh Journal of Veternary Medicine 11: 51–56. DOI: https://doi.org/10.3329/bjvm.v11i1.16513

Payne J M, Dew S M and Mansto R. 1970. The use of a metabolic profile test in dairy herds. Veternariary Record 87: 150–58. Radostits O M, Gay C C, Blood D C and Hinchcliff K W. 2000. Veterinary Medicine. WB Saunders Company Limited, London 9: 1819–1822. DOI: https://doi.org/10.1136/vr.87.6.150

Samanta A, Patra A, Mandal S, Roy S, Das K, Kar S and Nandi D K. 2018. Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology. Saudi Journal of Kidney Disease and Transplantation 29: 879–88. DOI: https://doi.org/10.4103/1319-2442.239653

Sevnic M, Basoglu A, Guzelbektas H and Boydak M. 2003. Lipid and lipoprotein levels in dairy cows with fatty liver. Turkish Journal of Veterinary and Animal Sciences 27: 295–99.

Sodhi M, Kataria R S, Niranjan S K, Kumari P, Verma P, Swami S K, Sharma A, Bharti V K, Kumar B, Iqbal M, Rabgais S, Kumar P, Giri A, Kalia S, Gagoi D, Sarangi P P and Mukesh M. 2018. Sequence characterization and genotyping of allelic variants of beta casein gene establishes native cattle of Ladakh to be a natural resource for A2 milk. Defence Life Science Journal 3: 177–81. DOI: https://doi.org/10.14429/dlsj.3.12574

Temte J L. 1996. Elevation of serum cholesterol at high altitude and its relationship to hematocrit. Wilderness and Environmental Medicine 3: 216–24. DOI: https://doi.org/10.1580/1080-6032(1996)007[0216:EOSCAH]2.3.CO;2

Verma P, Sharma A, Sodhi M, Thakur K, Bharti V K, Kumar P, Giri A, Kalia S, Swami S K and Mukesh M. 2018b. Overexpression of genes associated with hypoxia in cattle adapted to Trans Himalayan region of Ladakh. Cell Biology International 42: 1141–48. DOI: https://doi.org/10.1002/cbin.10981

Verma P, Sharma A, Sodhi M, Thakur K, Kataria R S, Niranjan S K, Bharti V K, Kumar P, Giri A, Kalia S and Mukesh M. 2018a. Transcriptome analysis of circulating PBMCs to understand mechanism of high altitude adaptation in native cattle of Ladakh region. Scientific Report 8: 7681–96. DOI: https://doi.org/10.1038/s41598-018-25736-7