Temporal changes in circulating progesterone and pregnancy-associated glycoprotein concentrations in Jakhrana goats with failed pregnancy

N SHARMA; S P SINGH; A BHARADWAJ

doi:10.56093/ijans.v90i6.104984

Authors

N SHARMA ICAR-Central Institute for Research on Goats, Makhdoom, Farah, Mathura, Uttar Pradesh 281 122 India
S P SINGH ICAR-Central Institute for Research on Goats, Makhdoom, Farah, Mathura, Uttar Pradesh 281 122 India
A BHARADWAJ ICAR-Central Institute for Research on Goats, Makhdoom, Farah, Mathura, Uttar Pradesh 281 122 India

https://doi.org/10.56093/ijans.v90i6.104984

Keywords:

Abortion, Goats, Pregnancy-associated glycoprotein, Progesterone

Abstract

This study aimed to evaluate the changes in circulating Progesterone (P4) and Pregnancy-Associated Glycoprotein (PAG) during pregnancy interrupted by abortion and to identify the better predictor of abortion risk in Jakhrana goats. Pluriparous goats (18) were involved in the study. Out of 15 pregnant goats, 3 goats were aborted during the third or fourth months of pregnancy. In the normal pregnancy, mean P4 concentration (13.96±0.27 ng/mL) remained unchanged throughout gestation whereas, the PAG level increased during early pregnancy and reached to the highest level (S-N=2.14±0.40) on day 51 of gestation. In non-pregnant goats, the P4 (0.3±0.03 ng/mL) and PAG (0.06±0.03) were significantly lower compared to the goats with maintained or failed pregnancy. In goats with the failed pregnancy, the PAG level started to decline about 12 days before the drop in P4 concentration (day 33.0±2.1 vs 21.3±3.5, before the occurrence of abortion). The mean PAG level in goats with failed pregnancy (0.33±0.03) was 4.8-folds lower compared to the animals with maintained pregnancy (1.58±0.08). In conclusion, the P4 and PAG concentrations in maternal circulation are changed by the pregnancy status and abortion. Plasma PAG is a more reliable predictor for the high risk of pregnancy failure than the P4 concentration in goats.

Downloads

Download data is not yet available.

References

Ali M, Gebbie F E, Sinclair K D, Broadbent P J, Hutchinson J S M, Beckers J F and Sulon J. 1997. Half-life of serum bovine pregnancy-associated glycoprotein (bPAG), postpartum anoestrus and performance of beef cows. Journal of Reproduction and Fertility Abstract Series 20: 25.

Charallah S, Amirat Z, Sulon J, Khammar F and Beckers J F. 2010. Pregnancy-Associated glycoprotein and progesterone concentrations during pregnancy failure in bedouin goat from the Southwest of Algeria. Reproduction in Domestic Animals 45: 231–38. DOI: https://doi.org/10.1111/j.1439-0531.2009.01511.x

Garbayo J M, Remy B, Alabart J L, Folch J, Wattiez R and Falmagne P. 1998. Isolation and partial characterization of a pregnancy-associated glycoprotein family from the goat placenta. Biology of Reproduction 58: 109–15. DOI: https://doi.org/10.1095/biolreprod58.1.109

Goossens B, Osaer S and Kora S. 1997. Long term effects of an experimental infection with Trypanosoma congolense on reproductive performance of trypanotolerant Djallonke ewe and West African Dwarf does. Research in Veterinary Science 63: 169–73. DOI: https://doi.org/10.1016/S0034-5288(97)90013-8

Haugejorden G, Waage S, Dah E, Karlberg K, Beckers J F and Ropsta E. 2006. Pregnancy associated glycoproteins (PAG) in postpartum cows, ewes, goats and their offspring. Theriogenology 66: 1976–84. DOI: https://doi.org/10.1016/j.theriogenology.2006.05.016

Jourdain E, Gibert P, Gauthier D, Fromont E, Jullien J M and Hars J. 2005. Sondagesurles maladies abortives chez les ongule´ s sauvagesetdomestiquesenalpages. Enqueˆ temene´ e dans la RNCFS des Bauges. Gibier Faune Sauvage 268: 24–32.

Menzies P I. 2011. Control of important causes of infectious abortion in sheep and goats. Veterinary Clinic: Food Animal Practice 27: 81–93. DOI: https://doi.org/10.1016/j.cvfa.2010.10.011

Osaer S, Goossens B, Kora S, Gaye M and Darboe L. 1999. Health and productivity of traditionally managed Djallonke sheep and West African Dwarf goats under high and moderate trypanosomosis risk. Journal of Veterinary Parasitology 82: 101–19. DOI: https://doi.org/10.1016/S0304-4017(99)00011-4

Roberts J N, May K J and Veiga-Lopez A. 2017. Time-dependent changes in pregnancy-associated glycoproteins and progesterone in commercial crossbred sheep. Theriogenology 89: 271–79. DOI: https://doi.org/10.1016/j.theriogenology.2016.10.029

Sawada T, Nakatani T, Tamada H and Mori J. 1994. Secretion of progesterone and 20 alpha-dihydroprogesterone during pregnancy in goats. Steroids 59: 468–71. DOI: https://doi.org/10.1016/0039-128X(94)90059-0

Short R V and Rowell J G. 1963. The half-life of progesterone in the peripheral blood of ewe at two stages of gestation. Journal of Endocrinology 25: 369–74. DOI: https://doi.org/10.1677/joe.0.0250369

Singh S P, Natesana R, Sharma N, Goel A K, Singh M K and Kharche S D. 2019. Pregnancy-associated glycoprotein profile in milk and its relationship with the circulating level during early pregnancy in goats. Small Ruminant Research 173: 81– 87. DOI: https://doi.org/10.1016/j.smallrumres.2019.02.017

Waldeland H and Loken T. 1991. Reproductive failure in goats in Norway: an investigation in 24 herds. Acta Veterinaria Scandinavica 32: 535–41. DOI: https://doi.org/10.1186/BF03546955

Wallace J M, Aitken R P, Cheyne M A and Humblot P. 1997. Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnancy outcome in growing adolescent ewes carrying singleton fetuses. Journal of Reproduction and Fertility 109: 53–58. DOI: https://doi.org/10.1530/jrf.0.1090053