Pharmacokinetic evaluation of cefquinome in febrile goats following intravenous administration

RASHMI SAGAR; MUDASIR SULTANA; VINOD K. DUMKA; PRITAM K. SIDHU

doi:10.56093/ijans.v90i10.111249

Authors

RASHMI SAGAR Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu and Kashmir, India
MUDASIR SULTANA Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab
VINOD K. DUMKA Institute of Computational and Comparative Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
PRITAM K. SIDHU Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu and Kashmir 180 009 India

https://doi.org/10.56093/ijans.v90i10.111249

Keywords:

Cefquinome, E. coli LPS, Fever, Goats, Intravenous, Pharmacokinetics, PK-PD

Abstract

Pharmacokinetics of cefquinome was studied in febrile female goats following its intravenous (IV) administration at the dose rate of 2 mg/kg body weight. The fever was induced by administration of Escherichia coli lipopolysaccharide (lμg/kg body weight). Cefquinome concentration in plasma of goats was estimated using HPLC. The drug was detected upto 24 h in febrile goats. The disposition kinetics of the drug was described by twocompartment open model. PK-PD indices; AUC_24h/MIC, C_max/MIC, T>MIC were calculated by integrating in-vivo PK data with earlier generated MIC data against Pasteurella (P.) multocida. A favourable PK and PK-PD indices suggested that the dose of 2 mg/kg/24 h of cefquinome would be effective clinically to treat goats affected with P. multocida infections.

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