Pharmacokinetic evaluation of cefquinome in febrile goats following intravenous administration

RASHMI SAGAR; MUDASIR SULTANA; VINOD K. DUMKA; PRITAM K. SIDHU

doi:10.56093/ijans.v90i10.111249

Authors

RASHMI SAGAR Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu and Kashmir, India
MUDASIR SULTANA Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab
VINOD K. DUMKA Institute of Computational and Comparative Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
PRITAM K. SIDHU Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu and Kashmir 180 009 India

https://doi.org/10.56093/ijans.v90i10.111249

Keywords:

Cefquinome, E. coli LPS, Fever, Goats, Intravenous, Pharmacokinetics, PK-PD

Abstract

Pharmacokinetics of cefquinome was studied in febrile female goats following its intravenous (IV) administration at the dose rate of 2 mg/kg body weight. The fever was induced by administration of Escherichia coli lipopolysaccharide (lμg/kg body weight). Cefquinome concentration in plasma of goats was estimated using HPLC. The drug was detected upto 24 h in febrile goats. The disposition kinetics of the drug was described by twocompartment open model. PK-PD indices; AUC_24h/MIC, C_max/MIC, T>MIC were calculated by integrating in-vivo PK data with earlier generated MIC data against Pasteurella (P.) multocida. A favourable PK and PK-PD indices suggested that the dose of 2 mg/kg/24 h of cefquinome would be effective clinically to treat goats affected with P. multocida infections.

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References

Allan M J and Thomas E. 2003. Pharmacokinetics of cefquinome after parenteral administration of an aqueous solution in the horse. Journal of Veterinary Pharmacology and Therapeutics 26(1): 82–307. DOI: https://doi.org/10.1046/j.1365-2885.2003.00485.x

Al-TaherA Y. 2010. Pharmacokinetics of cefquinome in camels. Journal of Animal and Veterinary Advances 9(4): 848–52. DOI: https://doi.org/10.3923/javaa.2010.848.852

Ambrose P G, Bhavnani S M, Rubino C M, Louie A, Gumbo T, Forrest A and Drusano G L. 2007. Pharmacokineticspharmacodynamics of antimicrobial therapy: it’s not just for mice anymore. Clinical Infectious Diseases 44(1): 79–86. DOI: https://doi.org/10.1086/510079

Balaje R M, Sidhu P K, Kaur G and Rampal S. 2013. Mutant prevention concentration and PK–PD relationships of enrofloxacin for Pasteurella multocida in buffalo calves. Research in Veterinary Science 95(3): 1114–24. DOI: https://doi.org/10.1016/j.rvsc.2013.07.019

Chaudhary R K, Srivastava A K and Rampal S. 1999. Modification of the pharmacokinetics and dosage of cefuroxime by endotoxin-induced fever in buffalo calves. Veterinary Research Communications 23(6): 361–68. DOI: https://doi.org/10.1023/A:1006385624850

Dardi M S, Sharma S K and Srivastava A K. 2005. Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves. Journal of Veterinary Science 6: 147–50. DOI: https://doi.org/10.4142/jvs.2005.6.2.147

Dinakaran V, Dumka V K, Ranjan B, Balaje R and Sidhu P K. 2013. Pharmacokinetics following intravenous administration and pharmacodynamics of cefquinome in buffalo calves. Tropical Animal Health and Production 45: 1509–12. DOI: https://doi.org/10.1007/s11250-013-0390-7

Dinakaran V and Dumka V K. 2015. Pharmacokinetic profile of cefquinome after oral subchronic flubendiamide exposure and in vitro plasma protein binding in buffalo calves. Environmental Toxicology and Pharmacology 39(1): 321–26. DOI: https://doi.org/10.1016/j.etap.2014.12.004

Dumka V K, Dinakaran V, Bibhuti R and Satyavan R. 2013. Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats. Small Ruminant Research 113: 273–77. DOI: https://doi.org/10.1016/j.smallrumres.2013.02.010

Ehinger A M, Schmidt H and Kietzmann M. 2006. Tissue distribution of cefquinome after intramammary and systemic administration in the isolated perfused bovine udder. Veterinary Journal 172(1): 147–53. Guerin-Faublee V, Carret G and Houffschmitt P. 2003. In vitro activity of 10 antimicrobial agents against bacteria isolated from cows with clinical mastitis. Veterinary Record 152(15): 466–71. DOI: https://doi.org/10.1016/j.tvjl.2005.02.029

Jamali H, Rezagholipour M, Fallah S, Dadrasnia A, Chelliah S, Velappan R D, Wei K S C and Ismail S. 2014. Prevalence, characterization and antibiotic resistance of Pasteurella multocida isolated from bovine respiratory infection. Veterinary Journal 202(2): 381–83. DOI: https://doi.org/10.1016/j.tvjl.2014.07.024

Lam F C, Hung C T and Perrier D G. 1985. Estimation of variance for harmonic mean half lives. Journal of Pharmaceutical Sciences 74(2): 229–31. DOI: https://doi.org/10.1002/jps.2600740229

Lees P, Concordet D, Toutain P L and Aliabadi F S. 2006. Drug selection and optimization of dosage schedules to minimize antimicrobial resistance. Antimicrobial Resistance in Bacteria of Animal Origin. American Society of Microbiology 49–72. DOI: https://doi.org/10.1128/9781555817534.ch5

Levison M E and Levison J H. 2009. Pharmacokinetics and pharmacodynamics of antibacterial agents. Infectious Disease Clinics 23(4): 791–815. DOI: https://doi.org/10.1016/j.idc.2009.06.008

Momin M A, Islam M A, Khatun M M, Rahman M M and Islam M A. 2011. Characterization of bacteria associated with pneumonia in black bengal goats. Bangladesh Journal of Veterinary Medicine 9(1): 67–71. DOI: https://doi.org/10.3329/bjvm.v9i1.11215

Mouton J W, Ambrose P G, Canton R, Drusano G L, Harbarth S, MacGowan A, Theuretzbacher U and Turnidge J. 2011. Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective. Drug Resistance Updates 14(2): 107–17. DOI: https://doi.org/10.1016/j.drup.2011.02.005

Perrier D and Gibaldi M. 1974. Clearance and biologic half-life as indices of intrinsic hepatic metabolism. Journal of Pharmacology and Experimental Therapeutics 191(1): 17– 24.

Pipoz F, Perreten V and Meylan M. 2016. Bacterial resistance in bacteria isolated from the nasal cavity of Swiss dairy calves. Schweizer Archiv fur Tierheilkunde 158(6): 397–403. DOI: https://doi.org/10.17236/sat00065

Ranjan R, Roy B K, Ranjan A and Singh S K. 2011. Effect of E. coli endotoxin induced fever on the pharmacokinetic profile and dosage regimen of ceftriaxone in sheep (Ovis aries). Veterinarski Arhiv 81(4): 423–32.

Roberts J A, Webb S A and Lipman J. 2007. Cefepime versus ceftazidime: considerations for empirical use in critically ill patients. International Journal of Antimicrobial Agents 29(2): 117–28. DOI: https://doi.org/10.1016/j.ijantimicag.2006.08.031

Sagar R, Sultana M, Dumka V K, Mir A H, Daundkar P and Chirag S. 2015. Pharmacokinetics and dosage regimen of cefquinome in febrile female goats following intravenous administration. Journal of Veterinary Pharmacology and Toxicology 14(2): 74–78.

Salaheddin O H and Hanan M E. 2012. Pneumonia in goats in Sudan. International Journal of Animal and Veterinary Advances 4: 144–45.

Sarangi L N, Thomas P, Gupta S K, Priyadarshini A, Kumar S, Nagaleekar V K, Kumar A and Singh V P. 2015. Virulence gene profiling and antibiotic resistance pattern of Indian isolates of Pasteurella multocida of small ruminant origin. Comparative Immunology, Microbiology and Infectious Diseases 38: 33–39. DOI: https://doi.org/10.1016/j.cimid.2014.11.003

Schwarz S, Kehrenberg C, Salmon S A and Watts J L. 2004. In vitro activities of spectinomycin and comparator agents against Pasteurella multocida and Mannheimia haemolytica from respiratory tract infections of cattle. Journal of Antimicrobial Chemotherapy 53(2): 379–82. DOI: https://doi.org/10.1093/jac/dkh059

Shlaby M A, Goudah A, Gihan M K and Hassan A S. 2014. Disposition kinetics of cefquinome in healthy rabbits following intramuscular and oral administration. World Journal of Pharmacy and Pharmaceutical Sciences 4(1): 263–74.

Shan Q, Yang F, Wang J, Ding H and Zeng Z. 2014. Pharmacokinetic/pharmacodynamic relationship of cefquinome against Pasteurella multocida in a tissue cage model in yellow cattle. Journal of Veterinary Pharmacology and Therapeutic 37(2): 178–85. DOI: https://doi.org/10.1111/jvp.12076

Shantier S W. 2018. A review on the characteristic, properties and analytical methods of cefquinome sulphate: -lactam veterinary drug. Infect Disorders Drug Targets. doi: 10.2174/ 1871526518666181001122010.

Sidhu P K, Waraich G S, Kaur G, Daundkar P S, Sharma S K and Gehring R. 2018. Difference in the PK of ceftiofur in the presence and absence of nimesulide and implications for dose determination through PK/PD integration. Small Ruminant Research 159: 18–25. DOI: https://doi.org/10.1016/j.smallrumres.2017.12.005

Sirous S, Mohammed R M D, Gholam A K, Taghi T B and Abbas T. 2011. Pasteurella multocida pneumonic infection in goat: Hematological, biochemical, clinical and pathological studies. Small Ruminant Research 100: 189–94. DOI: https://doi.org/10.1016/j.smallrumres.2011.07.006

Thomas E, Thomas V and Wilhelm C. 2006. Antibacterial activity of cefquinome against equine bacterial pathogens. Veterinary Microbiology 115: 140–47. DOI: https://doi.org/10.1016/j.vetmic.2005.12.019

Tohamy M A. 2011. Age-related intramuscular pharmacokinetics of cefquinome in sheep. Small Ruminant Research 99: 72–76. DOI: https://doi.org/10.1016/j.smallrumres.2011.03.004

Uney K, Altan F and Elmas M. 2011. Development and validation of a high-performance liquid chromatography method for determination of cefquinome concentrations in sheep plasma and its applica-tion to pharmacokinetic studies. Antimicrob Agents Chemotherapy 55: 854–59. DOI: https://doi.org/10.1128/AAC.01126-10