Main risk factors associated with small and large ruminant brucellosis

MARYAM DADAR; JACQUES GODFROID

doi:10.56093/ijans.v91i11.118115

Authors

MARYAM DADAR Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran
JACQUES GODFROID Department of Arctic and Marine Biology, Faculty of Biosciences, Fisheries and Economics, UiT-The Arctic University of Norway; Tromsø, Norway

https://doi.org/10.56093/ijans.v91i11.118115

Keywords:

Brucellosis, Large ruminant, Risk factor, Small ruminant

Abstract

Brucellosis is a neglected zoonotic bacterial disease in most of the developing world that has a significant impact on public health. The prevalence of brucellosis in livestock, particularly in large and small ruminants is variable in many countries and seems to remain high, especially amongst subsistence and small-scale livestock farmers. There are different factors that may influence the prevalence of brucellosis in large and small ruminants. This review is aimed at describing the most important factors that need to be taken into consideration for the planning and implementation of effective brucellosis control programmes. Common risk factors in the brucellosis development in small and large ruminant animals include species, age, sex, extensive or intensive production system, herd/flock size, mixed farming, introduction of new animals in the farms, breeding practice, hygiene, absence of vaccination, and awareness of the disease. This review suggests that different risk factors might have various impacts on brucellosis seroprevalence that need to be addressed in epidemiological studies in different farming systems.

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References

Abnaroodheleh F, Emadi A and Dadar M. 2021. Seroprevalence of brucellosis and chlamydiosis in sheep and goats with history of abortion in Iran. Small Ruminant Research.

Abubakar M, Mansoor M and Arshed M J. 2012. Bovine brucellosis: Old and new concepts with Pakistan perspective.

Pakistan Veterinary Journal 32(2).

Adem A, Hiko A, Waktole H, Abunna F, Ameni G and Mamo G. 2021. Small ruminant Brucella seroprevalence and potential risk factor at Dallo-manna and Harannabulluk districts of Bale zone, Oromia regional state, Ethiopia. Ethiopian Veterinary Journal 25(1): 77–95.

Akinseye V O, Adesokan H K, Ogugua A J, Adedoyin F J, Otu P I, Kwaghe A V, Kolawole N O, Okoro O J, Agada C A and Tade A O. 2016. Sero-epidemiological survey and risk factors associated with bovine brucellosis among slaughtered cattle in Nigeria. Onderstepoort Journal of Veterinary Research 83(1): 1–7.

Al-Majali A M, Al-Qudah K M, Al-Tarazi Y H and Al-Rawashdeh O F. 2008. Risk factors associated with camel brucellosis in Jordan. Tropical Animal Health and Production 40(3): 193–200.

Alamian S and Dadar M. 2019. Brucella abortus contamination of camel milk in two Iranian regions. Preventive Veterinary Medicine 169: 104708.

Alamian S and Dadar M. 2020. Brucella melitensis infection in dog: a critical issue in the control of brucellosis in ruminant farms. Comparative Immunology, Microbiology and Infectious Diseases 73: 101554.

Angara T, AAA I I A and Osman S. 2016. Assessment of the economic losses due to bovine brucellosis in Khartoum State, Sudan. International Journal of Technical Research and Applications 4(2): 85–90.

Asgedom H, Damena D and Duguma R. 2016. Seroprevalence of bovine brucellosis and associated risk factors in and around Alage district, Ethiopia. SpringerPlus 5(1): 851.

Aune K, Rhyan J C, Russell R, Roffe T J and Corso B. 2012. Environmental persistence of Brucella abortus in the Greater Yellowstone Area. Journal of Wildlife Management 76(2): 253–61.

Awah-Ndukum J, Mouiche M, Bayang H, Ngwa V N, Assana E, Feussom K, Manchang T and Zoli P. 2018. Seroprevalence and associated risk factors of brucellosis among indigenous cattle in the Adamawa and north regions of Cameroon.Veterinary Medicine International 2018.

B Lopes L, Nicolino R and P A Haddad J. 2010. Brucellosis-risk factors and prevalence: A review. Open Veterinary Science Journal 4(1).

Bamaiyi P H. 2015. The economic impact attributable to brucellosis among goat farms in Peninsula Malaysia and cost

benefit analysis.Research Opinions in Animal Veterinary Sciences 5: 57–64.

Banai M. 2002. Control of small ruminant brucellosis by use of Brucella melitensis Rev. 1 vaccine: laboratory aspects and field observations. Veterinary Microbiology 90(14): 497–519.

Behera S K, Das D, Balasubramani K, Chellappan S, Rajaram K, Mohanta H K and Nina P B. 2020. Seroprevalence and risk factors of brucellosis in livestock in the wildlife and livestock interface area of Similipal Biosphere Reserve, India. Veterinary World 13(3): 465.

Blasco J M and Molina-Flores B. 2011. Control and eradication of Brucella melitensis infection in sheep and goats. Veterinary Clinics: Food Animal Practice 27(1): 95–104.

Capparelli R, Parlato M, Iannaccone M, Roperto S, Marabelli R, Roperto F and Iannelli D. 2009. Heterogeneous shedding of Brucella abortus in milk and its effect on the control of animal brucellosis. Journal of Applied Microbiology 106(6): 2041–47.

Carbonero A, Guzmán L, García-Bocanegra I, Borge C, Adaszek L, Arenas A and Saa L. 2018. Seroprevalence and risk factors associated with Brucella seropositivity in dairy and mixed cattle herds from Ecuador. Tropical Animal Health and Production 50(1): 197–203.

Cheville N F, Olsen S C, Jensen A E, Stevens M G, Palmer M V and Florance A M. 1996. Effects of age at vaccination on

efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis. American Journal of Veterinary Research

(8): 1153–56.

Coelho A, Coelho A, Roboredo M and Rodrigues J. 2007. A case–control study of risk factors for brucellosis seropositivity in Portuguese small ruminants herds. Preventive Veterinary Medicine 82(34): 291–301.

Corbel M J. 1997. Brucellosis: An overview. Emerging Infectious Diseases 3(2): 213.

Cowie C E, Marreos N, Gortázar C, Jaroso R, White P C and Balseiro A. 2014. Shared risk factors for multiple livestock

diseases: A case study of bovine tuberculosis and brucellosis. Research in Veterinary Science 97(3): 491–97.

Dabassa G, Tefera M and Addis M. 2013. Small ruminant brucellosis: serological survey in Yabello district, Ethiopia.

Asian Journal of Animal Science 7: 14–21.

Dadar M and Alamian S. 2020. Isolation of Brucella melitensis from seronegative camel: potential implications in brucellosis control. Preventive Veterinary Medicine 185: 105–194.

Dadar M, Alamian S, Behrozikhah A M, Yazdani F, Kalantari A, Etemadi A and Whatmore A M. 2019a. Molecular identification of Brucella species and biovars associated with animal and human infection in Iran. Veterinary Research Forum, pp 315–20. Faculty of Veterinary Medicine, Urmia University.

Dadar M, Shahali Y and Fakhri Y. 2020. A primary investigation of the relation between the incidence of brucellosis and climatic factors in Iran. Microbial Pathogenesis 139: 103858.

Dadar M, Shahali Y and Wareth G. 2019a. Molecular Diagnosis of Acute and Chronic Brucellosis in Humans. Microbial

Technology for the Welfare of Society, pp 223–45. Springer.

Dadar M, Shahali Y and Whatmore A M. 2019b. Human brucellosis caused by raw dairy products: A review on the

occurrence, major risk factors and prevention. International Journal of Food Microbiology 292: 39–47.

Dadar M, Wareth G and Neubauer H. 2021. Brucellosis in Iranian buffalo: A mini review. German Journal of Veterinary

Research.

de Oliveira M M, Pereira C R, de Oliveira I R C, Godfroid J, Lage A P and Dorneles E M S. 2021. Efficacy of Brucella

abortus S19 and RB51 vaccine strains: a systematic review and meta analysis. Transboundary and Emerging Diseases.

Deka R P, Magnusson U, Grace D and Lindahl J. 2018. Bovine brucellosis: prevalence, risk factors, economic cost and control options with particular reference to India—A review. Infection Ecology and Epidemiology 8(1): 1556548.

Erganis O, Hadimli H H, Solmaz H and Corlu M. 2005. Brucella melitensis and Brucella suis. Bulletin of the Veterinary Institute in Pulawy 49: 165–67.

Fatima S, Khan I, Nasir A, Younus M, Saqib M, Melzer F, Neubauer H and El-Adawy H. 2016. Serological, molecular

detection and potential risk factors associated with camel brucellosis in Pakistan. Tropical Animal Health and Production 48(8): 1711–18.

Fiebig A, Vrentas C E, Le T, Huebner M, Boggiatto P M, Olsen S C and Crosson S. 2021. Quantification of Brucella abortus population structure in a natural host. Proceedings of the National Academy of Sciences 118(11).

Franc K, Krecek R, Häsler B and Arenas-Gamboa A. 2018. Brucellosis remains a neglected disease in the developing

world: A call for interdisciplinary action. BMC Public Health 18(1): 125.

Geresu M A, Ameni G, Tuli G, Arenas A and Kassa G M. 2016. Seropositivity and risk factors for Brucella in dairy cows in Asella and Bishoftu towns, Oromia Regional State, Ethiopia. African Journal of Microbiology Research 10(7): 203–13.

Ghanem Y M, El-Khodery S A, Saad A A, Abdelkader A H, Heybe A and Musse Y A. 2009. Seroprevalence of camel brucellosis (Camelus dromedarius) in Somaliland. Tropical Animal Health and Production 41(8): 1779.

Godfroid J, Al Dahouk S, Pappas G, Roth F, Matope G, Muma J, Marcotty T, Pfeiffer D and Skjerve E. 2013. A “One Health” surveillance and control of brucellosis in developing countries: Moving away from improvisation. Comparative Immunology, Microbiology and Infectious Diseases 36(3): 241–48.

Gumaa M, Osman H, Omer M, El Sanousi E M, Godfroid J and Ahmed A. 2014. Seroprevalence of brucellosis in sheep and isolation of Brucella abortus biovar 6 in Kassala State, Eastern Sudan.

Halliday J E, Allan K J, Ekwem D, Cleaveland S, Kazwala R R and Crump J A. 2015. One health: Endemic zoonoses in the

tropics: A public health problem hiding in plain sight. Veterinary Record 176(9): 220.

Herrera E, Palomares G and Díaz Aparicio E. 2008. Milk production increase in a dairy farm under a six year brucellosis control program. Annals of the New York Academy of Sciences 1149(1): 296–99.

Janowicz A, De Massis F, Zilli K, Ancora M, Tittarelli M, Sacchini F, Di Giannatale E, Sahl J W, Foster J T and Garofolo G. 2020. Evolutionary history and current distribution of the West Mediterranean lineage of Brucella melitensis in Italy.

Microbial Genomics 6(11).

Kaynak-Onurdag F, Okten S and Sen B. 2016. Screening Brucella spp. in bovine raw milk by real-time quantitative PCR and conventional methods in a pilot region of vaccination, Edirne, Turkey. Journal of Dairy Science 99(5): 3351–57.

Kelkay M Z, Gugsa G, Hagos Y and Taddelle H. 2017. Seroprevalence and associated risk factors for Brucella

seropositivity among small ruminants in Tselemti districts, Northern Ethiopia. Journal of Veterinary Medicine and Animal Health 9(11): 320–26.

Khurana S K, Sehrawat A, Tiwari R, Prasad M, Gulati B, Shabbir M Z, Chhabra R, Karthik K, Patel S K and Pathak M. 2021. Bovine brucellosis–A comprehensive review. Veterinary Quarterly 41(1): 61–88.

Lindahl E, Sattorov N, Boqvist S, Sattori I and Magnusson U. 2014. Seropositivity and risk factors for Brucella in dairy cows in urban and peri-urban small-scale farming in Tajikistan. Tropical Animal Health and Production 46(3): 563–69.

Lokamar P N, Kutwah M A, Atieli H, Gumo S and Ouma C. 2020. Socio-economic impacts of brucellosis on livestock

production and reproduction performance in Koibatek and Marigat regions, Baringo County, Kenya. BMC Veterinary

Research 16(1): 1–13.

Mableson H E, Okello A, Picozzi K and Welburn S C. 2014. Neglected zoonotic diseases—the long and winding road to

advocacy. PLoS Neglected Tropical Diseases 8(6): e2800.

Mai H, Irons P, Kabir J and Thompson P. 2013. Herd-level risk factors for Campylobacter fetus infection, Brucella

seropositivity and within-herd seroprevalence of brucellosis in cattle in northern Nigeria. Preventive Veterinary Medicine 111(3–4): 256–67.

Matope G, Bhebhe E, Muma J, Lund A and Skjerve E. 2010. Herd-level factors for Brucella seropositivity in cattle reared in smallholder dairy farms of Zimbabwe. Preventive Veterinary Medicine 94(3–4): 213–21.

Megersa B, Biffa D, Abunna F, Regassa A, Godfroid J and Skjerve E. 2011. Seroprevalence of brucellosis and its contribution to abortion in cattle, camel, and goat kept under pastoral management in Borana, Ethiopia. Tropical Animal Health and Production 43(3): 651–56.

Mellado M, Garcia A M, Arellano-Reynoso B, Diaz-Aparicio E and Garcia J E. 2014. Milk yield and reproductive performance of brucellosis-vaccinated but seropositive Holstein cows. Tropical Animal Health and Production 46(2): 391–97.

Moosazadeh M, Abedi G, Kheradmand M, Safiri S and Nikaeen R. 2016. Seasonal pattern of brucellosis in Iran: A systematic review and meta-analysis. Iranian Journal of Health Sciences 4(1): 62–72.

Ning P, Guo M, Guo K, Xu L, Ren M, Cheng Y and Zhang Y. 2013. Identification and effect decomposition of risk factors for Brucella contamination of raw whole milk in China. PLoS ONE 8(7): e68230.

Olsen S. 2010. Brucellosis in the United States: Role and significance of wildlife reservoirs. Vaccine 28: F73–76.

Omer M, Skjerve E, Woldehiwet Z and Holstad G. 2000. Risk factors for Brucella spp. infection in dairy cattle farms in

Asmara, State of Eritrea. Preventive Veterinary Medicine 46(4): 257–65.

Pathak A D, Dubal Z, Karunakaran M, Doijad S P, Raorane A V, Dhuri R, Bale M, Chakurkar E B, Kalorey D R and Kurkure N V. 2016. Apparent seroprevalence, isolation and identification of risk factors for brucellosis among dairy cattle in Goa, India. Comparative Immunology, Microbiology and Infectious Diseases 47: 1–6.

Peck M E, Jenpanich C, Amonsin A, Bunpapong N, Chanachai K, Somrongthong R, Alexander B H and Bender J B. 2019. Knowledge, attitudes and practices associated with brucellosis among small-scale goat farmers in Thailand. Journal of Agromedicine 24(1): 56–63.

Primatika R A, Nugroho W S and Septana A I. 2016. Survey of brucellosis in goats using Rose Bengal Test (RBT) and

Complement Fixation Test (CFT) methods in Gunungkidul district, special region of Yogyakarta, Indonesia. AIP Conference Proceedings, p 040006. AIP Publishing LLC.

Saleem M Z. 2019. Role of ticks in transmission of brucellosis and skin/hide damage in small and large ruminants. University of Veterinary and Animal Sciences, Lahore.

Santos R L, Martins T M, Borges Á M and Paixão T A. 2013. Economic losses due to bovine brucellosis in Brazil. Pesquisa Veterinária Brasileira 33(6): 759–64.

Seleem M N, Boyle S M and Sriranganathan N. 2010. Brucellosis: A re-emerging zoonosis. Veterinary Microbiology 140(3–4): 392–98.

Singh B, Dhand N K and Gill J. 2015. Economic losses occurring due to brucellosis in Indian livestock populations. Preventive Veterinary Medicine 119(3–4): 211–15.

Sulima M and Venkataraman K. 2010. Economic losses due to Brucella melitensis infection in sheep and goats. Tamil Nadu Journal of Veterinary and Animal Sciences 6(4): 191–92.

Teklue T, Tolosa T, Tuli G, Beyene B and Hailu B. 2013. Seroprevalence and risk factors study of brucellosis in small

ruminants in Southern Zone of Tigray Region, Northern Ethiopia. Tropical Animal Health and Production 45(8): 1809–

Terefe Y, Girma S, Mekonnen N and Asrade B. 2017. Brucellosis and associated risk factors in dairy cattle of eastern Ethiopia. Tropical Animal Health and Production 49(3): 599–606.

Tittarelli M, Di Ventura M, De Massis F, Scacchia M, Giovannini A, Nannini D and Caporale V. 2005. The persistence of Brucella melitensis in experimentally infected ewes through three reproductive cycles. Journal of Veterinary Medicine, Series B 52(9): 403–09.

Tukana A and Gummow B. 2017. Dairy farm demographics and management factors that played a role in the re-emergence of brucellosis on dairy cattle farms in Fiji. Tropical Animal Health and Production 49(6): 1171–78.

Ukita M, Hozé N, Nemoto T, Cauchemez S, Asakura S, Makingi G, Kazwala R and Makita K. 2021. Quantitative

evaluation of the infection dynamics of bovine brucellosis in Tanzania. Preventive Veterinary Medicine.

Wareth G, Melzer F, Elschner M C, Neubauer H and Roesler U. 2014. Detection of Brucella melitensis in bovine milk and milk products from apparently healthy animals in Egypt by realtime PCR. Journal of Infection in Developing Countries 8(10): 1339–43.

Wareth G, Melzer F, Tomaso H, Roesler U and Neubauer H. 2015. Detection of Brucella abortus DNA in aborted goats and sheep in Egypt by real-time PCR. BMC Research Notes 8(1): 1–5.

Whatmore A M, Koylass M S, Muchowski J, Edwards-Smallbone J, Gopaul K K and Perrett L L. 2016. Extended multilocus sequence analysis to describe the global population structure of the genus Brucella: Phylogeography and relationship to biovars. Frontiers in Microbiology 7: 2049.

Yang X, Skyberg J A, Cao L, Clapp B, Thornburg T and Pascual D W. 2013. Progress in Brucella vaccine development.

Frontiers in Biology 8(1): 60–77.