Laboratory animal mycoplasmosis: A mini review

SALEEM KHAN; RAJNEESH RANA

doi:10.56093/ijans.v91i11.118116

Authors

SALEEM KHAN ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
RAJNEESH RANA ICAR, KAB II, Pusa, New Delhi

https://doi.org/10.56093/ijans.v91i11.118116

Keywords:

CAR bacillus, Laboratory animals, Mycoplasmosis, PCR-RFLP

Abstract

Mycoplasmas are the smallest, free-living, cell wall less prokaryotes from the class mollicutes, and these are relatively slow-growing microorganisms. Most of the laboratory animals may get the mycoplasma infection naturally. A large number of mycoplasma species (Mycoplasma pulmonis, M. muris, M. neurolyticum, M. collis, M. arthritidis and M. caviae etc.) have been reported from the laboratory animals. These are responsible for the development of a large numbers of clinical conditions in laboratory animals hence they may cause interference in the results of on-going research/experimental works on those laboratory animals. This review article gives insights on laboratory animal mycoplasma infections including pathogenesis, clinical signs, lesions, diagnosis, and interference in the experimental work, prevention, and control.

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References

Baker D G. 2003. Natural pathogens of laboratory animals: Their effects on research. ASM Press, Washington, DC. 385 pp.

Bhatt P N, Jacoby R O, Morse H C and New A (Eds). 1986. Viral and mycoplasma infections of laboratory rodents: Effects on biomedical research. Academic Press, New York.

Brown M B, Peltier M, Hillier M, Crenshaw B and Reyes L. 2001. Genital mycoplasmosis in rats: A model for intrauterine infection. American Journal of Reproductive Immunology 46 (3): 232–41.

Cassell G H, Lindsey J R and Davis J K. 1981a. Respiratory and genital mycoplasmosis of laboratory rodents: Implications for biomedical research. Israel Journal of Medical Sciences 17: 548–54.

Cassell G H, Lindsey J R, Davis J K, Davidson M K, Brown M B and Mayo J G. 1981b. Detection of natural Mycoplasma

pulmonis infection in rats and mice by an enzyme linked immunosorbent assay (ELISA). Laboratory Animal Science 31(6): 676–82.

Cedillo L, Gil C, Mayagoitia G, Giono S, Cuéllar Y and Yaiez A. 1992. Experimental arthritis induced by Mycoplasma

pneumoniae in rabbits. Journal of Rheumatology 19(3): 344–47.

Cox N R, Davidson M K, Davis J K, Lindsey J R and Cassell G H. 1988. Natural mycoplasmal infections in isolator-maintained LEW/Tru rats. Laboratory Animal Science 38(4): 381–88.

Davidson M K, Davis J K, Gambill G P, Cassell G H and Lindsey J R. 1994. Mycoplasmas of laboratory rodents. (Eds) Whitford H W, Rosenbusch R F and Lauerman L H. Mycoplasmosis in Animals: Laboratory Diagnosis, pp. 97–133. Iowa State University Press, Iowa.

Davis J, Cassell G H, Gambill G, Cox N, Watson H and Davidson M. 1987. Diagnosis of murine mycoplasmal infections by enzyme-linked immunosorbent assay (ELISA). Israel Journal of Medical Sciences 23(6): 717–22.

Ferebee A, Simoneau P, Chang J, Barile M F and Hu P. 1992. Differential detection of Mycoplasma pulmonis and

Mycoplasma arthritidis with species-specific DNA probes. Diagnostic Microbiology and Infectious Disease 15(5): 411–

Fox J G, Anderson L C, Lowe F M and Quimby F W (Eds). 2002. Laboratory Animal Medicine. 2nd ed. Academic Press, San Diego. 1325 pp.

George M and Garrity S C. 2005. D Bergey’s Manual Trust. Bergey’s Manual of Systematic Bacteriology. 2nd edn.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, USA.

Graham J E and Schoeb T R. 2011. Mycoplasma pulmonis in rats. Journal of Exotic Pet Medicine 20: 270–76.

Hill A C. 1971. Incidence of mycoplasma infection in guineapigs. Nature 232(5312): 560.

Hill A C. 1971. Mycoplasma caviae, a new species. Journal of General Microbiology 65(1): 109–13.

Hill A C. 1984. Mycoplasma cavipharyngis, a new species isolated from the nasopharynx of Guinea-pigs. Journal of General Microbiology 130(12): 3183–88.

Hodge L M and Simecka J W. 2002. Role of upper and lower respiratory tract immunity in resistance to Mycoplasma

respiratory disease. Journal of Infectious Diseases 186(2): 290–94.

Jacobs E, Watter T, Schaefer H E and Bredt W. 1991. Comparison of host responses after intranasal infection of guinea-pigs with Mycoplasma genitalium or with Mycoplasma pneumoniae. Microbial Pathogenesis 10(3): 221–29.

Kim D J, Park J H, Seok S H, Cho S A, Baek M W, Lee H Y, Yang K H, Jang D D, Han B S and Park J H. 2005. Differential identification of Mycoplasma pulmonis and M. arthritidis using PCR-based RFLP. Experimental Animals 54(4): 359–62.

Kohn D F and Clifford C B. 2002. Biology and diseases of rats. (Ed.) Fox J G. Laboratory Animal Medicine. San Diego, Calif Elsevier.

Kunita S, Terada E, Ghoda A, Sakurai Y, Suzuki H, Takakura A and Kagiyama N. 1989. A DNA probe for specific detection of Mycoplasma pulmonis. Jikken Dobutsu 38(3): 215–29.

Lindsey J R, Baker H J, Overcash R G, Cassell G H and Hunt C E. 1971. Murine chronic respiratory disease. Significance as a research complication and experimental production with Mycoplasma pulmonis. American Journal of Pathology 64:675–717.

Lindsey J R, Davidson M K, Schoeb T R and Cassell G H. 1985. Mycoplasma pulmonis-host relationships in a breeding colony of Sprague-Dawley rats with enzootic murine respiratory mycoplasmosis. Laboratory Animal Science 35(6): 597–608.

Lussier G. 1991. Detection methods for the identification of rodent viral and mycoplasmal infections. Laboratory Animal Science 41: 199–225.

Mahler M and Kohl W. 2009. A serological survey to evaluate contemporary prevalence of viral agents and Mycoplasma pulmonis in laboratory mice and rats in Western Europe. Laboratory Animal (NY) 38(5): 161–65.

Manjunath S, Kulkarni P G, Nagavelu K, Samuel R J, Srinivasan S, Ramasamy N, Hegde N R and Gudde R S. 2015. Seroprevalence of rodent pathogens in India. PLoS ONE 10(7): e0131706.

Nicklas W. 1993. Possible routes of contamination of laboratory rodents kept in research facilities. Scandanavian Journal of Laboratory Animal Science 20: 53–60.

Percy D H and Barthold S W B. 2001. Pathology of Laboratory Rodents and Rats. Iowa State University Press, Ames. pp. 126–130.

Percy D H and Barthold S W. 2007. Pathology of Laboratory Rodents and Rabbits. 3rd ed. Iowa State University Press,

Ames, Iowa. 325 pp.

Razin S. 1992. Mycoplasma taxonomy and ecology. (Eds) Maniloff J, McElhaney R N, Finch L R and Baseman J B.

Mycoplasmas: Molecular Biology and Pathogenesis, pp. 3–22. American Society of Microbiology, Washington.

Reyes L, Steiner D A, Hutchison J, Crenshaw B and Brown M B. 2000. Mycoplasma pulmonis genital disease: Effect of rat strain on pregnancy outcome. Comparative Medicine 50(6): 622–27.

Ross S E, Simecka J W, Gambill G P, Davis J K and Cassell G H. 1992. Mycoplasma pulmonis possesses a novel chemoattractant for B lymphocytes. Infectious Immunology 60: 669–74.

Simecka J W, Davis J K, Davidson M K, Davidson S E, Ross C T K and Stadtlander G H. 1992. Mycoplasma diseases of animals. (Eds) Maniloff J, Mcelhaney R N, Finch LR and Baseman J B. Mycoplasmas: Molecular biology and pathogenesis. ASM Press, Washington. pp. 391–416.

Van Kuppeveld F J M, Melchers W J G, Willemse H F, Kissing J, Galama J M D and Van Der Logt J T M. 1993. Detection of Mycoplasma pulmonis in experimental infected laboratory rats by 16S rRNA amplification. Journal of Clinical Microbiology 31: 524–27.

Vincent E V, Stark D M, Samberg N and McBride D F. 1984. Comparison of three serologic techniques for detection of

antibody to Mycoplasma pulmonis. Cornell Veterinarian 74(1): 21–29.

Waites K and Talkington D. 2005. New developments in human diseases due to mycoplasmas. (Eds) Blanchard A and

Browning G. Mycoplasmas: Molecular Biology, Pathogenicity, and Strategies for Control, pp. 289–354. Horizon bioscience, Norfolk.