Effects of dietary supplementation of different herbs on relative expression of Toll-like Receptors (TLRs) in poultry

JYOTSANA; NARENDER SINGH MAAN; AMAN KUMAR; SUSHILA MAAN

doi:10.56093/ijans.v93i04.123041

Authors

JYOTSANA Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
NARENDER SINGH MAAN Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
AMAN KUMAR Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
SUSHILA MAAN Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India

https://doi.org/10.56093/ijans.v93i04.123041

Keywords:

Immunity, Nutrition, Phytochemicals, Poultry, Toll-like receptor

Abstract

The paucity of novel antibiotics for treating human and animal infections has heightened global fears about growing drug-resistant superbugs. Antibiotic replacement approaches for food-producing animals, particularly poultry and livestock, are urgently needed by the agricultural business. The need of the hour is to develop and exploit promising antibiotic-alternative phytochemicals in order to minimize Antibiotic Growth Promoters and develop an antibiotic-free animal production system. Phytogenic plant dietary supplements have positive effects on poultry performance and immunity. Toll-like receptors (TLRs) play a key role in the innate immune system. TLRs recognize microbes that have broken through physical barriers such as the skin or the mucosa of the digestive tract, triggering immune cell responses. Supplementation of herbs in the dietary regimen of poultry had shown stimulatory effects on the immune system. Herbs such as Amla, Ashwagandha, Garlic powder, Giloy, Turmeric, Shatavari, Aloe vera, Moringa and holy basil have been shown to increase the relative mRNA expression of different toll-like receptors, thereby enhancing broiler immunological status by modulating their immune response.

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References

Abbas R Z, Iqbal Z, Khan M N, Zafar M A and Zia M A. 2010. Anticoccidial activity of Curcuma longa L. in broilers. Brazilian Archives of Biology and Technology 53: 63–67. https://doi.org/10.1590/S1516-89132010000100008 DOI: https://doi.org/10.1590/S1516-89132010000100008

Abou‐Douh A M. 2002. New withanolides and other constituents from the fruit of Withania somnifera. Archiv der Pharmazie. 335(6): 267–76. https://doi.org/10.1002/1521- 4184(200208)335:6%3C267::AID-ARDP267%3E3.0.CO;2-E DOI: https://doi.org/10.1002/1521-4184(200208)335:6<267::AID-ARDP267>3.0.CO;2-E

Adibmoradi M, Navidshad B, Seifdavati J and Royan M. 2006. Effect of dietary garlic meal on histological structure of small intestine in broiler chickens. Journal of Poultry Science 43: 378–83. https://doi.org/10.1017/S0043933912000530 DOI: https://doi.org/10.2141/jpsa.43.378

Agarwal R, Diwanay S, Patki P and Patwardhan B. 1999. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Journal of Ethnopharmacology 67(1): 27–35. https://doi.org/10.1016/s0378-8741(99)00065-3 DOI: https://doi.org/10.1016/S0378-8741(99)00065-3

Ahlawat P K. 2017. ‘Effect of Supplementation of Turmeric Powder (Curcuma longa) on growth performance, gut morphology and meat quality of Broilers.’ M.V.Sc. Thesis submitted to LUVAS, Hisar.

Allen P C and Fetterer R H. 2002. Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry. Clinical Microbiology Reviews 15: 58–65. https://dx.doi.org/10.1128%2FCMR.15.1.58-65.2002 DOI: https://doi.org/10.1128/CMR.15.1.58-65.2002

Amagase H, Petesch B L, Matsuura H, Kasuga S and Itakura Y. 2001. Intake of garlic and its bioactive components. Journal of Nutrition 131: 955S–962S. https://doi.org/10.1093/jn/131.3.955s DOI: https://doi.org/10.1093/jn/131.3.955S

Ammon H P T, Safayhi H, Mack T and Sabieraj J. 1993. Mechanism of anti-inflammatory actions of curcumin and boswellic acids. Journal of Ethnopharmacology 38: 113–19. https://doi.org/10.1016/0378-8741(93)90005-P DOI: https://doi.org/10.1016/0378-8741(93)90005-P

Attia G, El-Eraky W, Hassanein E, El-Gamal M, Farahat M and Santana A H. 2017. Effect of dietary inclusion of a plant extract blend on broiler growth performance, nutrient digestibility, cecal microflora and intestinal histomorphology. International Journal of Poultry Sciences 16: 344–53. https:// dx.doi.org/10.3923/ijps.2017.344.353 DOI: https://doi.org/10.3923/ijps.2017.344.353

Bhardwaj U, Tiwary B K, Prasad A and Ganguly S. 2012. Effect of Tinospora cordifolia extract on immune response and serum biochemical profile in broilers. Indian Journal of Animal Sciences 82(4): 379–81.

Boudreau M D and Beland F A. 2006. An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. Journal of Environment Science and Health 24: 103–54. https://doi.org/10.1080/10590500600614303 DOI: https://doi.org/10.1080/10590500600614303

Cabuk M, Bozkurt M, Alcicek A, Akbas Y and Kucukyilmaz K. 2006. Effect of a herbal essential oil mixture on growth and internal organ weight of broilers from young and old breeder flocks. South African Journal of Animal Sciences 36: 135–41. https://doi.org/10.4314/sajas.v36i2.3996 DOI: https://doi.org/10.4314/sajas.v36i2.3996

Caceres A, Cabrera O, Morales O, Mollinedo P and Mendia P. 1991. Pharmacological properties of Moringa oleifera. 1: Preliminary screening for antimicrobial activity. Journal of Ethnopharmacology 33(3): 213–16. https://doi. org/10.1016/0378-8741(91)90078-r DOI: https://doi.org/10.1016/0378-8741(91)90078-R

Castillo M, Martín-Orúe S M, Roca M, Manzanilla E G, Badiola I, Perez J F and Gasa J. 2006. The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs. Journal of Animal Sciences 84(10): 725–2734. https://doi.org/10.2527/jas.2004-556 DOI: https://doi.org/10.2527/jas.2004-556

Chandra R K. 1997. Nutrition and the immune system: An introduction. The American Journal of Clinical Nutrition 66: 460S–463S. https://doi.org/10.1093/ajcn/66.2.460s DOI: https://doi.org/10.1093/ajcn/66.2.460S

Cherng J M, Chiang W and Chiang L C. 2008. Immunomodulatory activities of common vegatables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chemistry 106: 944–50. https://doi.org/10.1016/j.foodchem.2007.07.005 DOI: https://doi.org/10.1016/j.foodchem.2007.07.005

Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwalla P, Ramakrishnan R. and Sainis K. 1999. An immunologically active arabinogalactan from Tinospora cordifolia. Phytochemistry 52: 1089–93. http://www.sciencedirect.com/science/article/pii/S0031942299003866 DOI: https://doi.org/10.1016/S0031-9422(99)00386-6

Cowan M M. 1999. Plant products as antimicrobial agent. Clinical Microbiological Reviews 12: 564–82. https://doi.org/10.1128/cmr.12.4.564 DOI: https://doi.org/10.1128/CMR.12.4.564

Dalal R. 2017. ‘Effect of supplementation of Amla (Emblica officinalis) fruit powder on growth performance, meat quality and gene expression in broilers.’ M.V.Sc. Thesis submitted to LUVAS, Hisar. DOI: https://doi.org/10.30954/2277-940X.08.2018.12

Darabighane B, Zarei A, Zare Shahneh A and Mahdavi A. 2011. Effects of different levels of Aloe vera gel as an alternative to antibiotic on performance and ileum morphology in broilers. Italian Journal of Animal Sciences 10: 189–94. https://doi.org/10.4081/ijas.2011.e36 DOI: https://doi.org/10.4081/ijas.2011.e36

Demir E, Sarica S, O’Zcan M A and Scicmez M. 2003. The use of natural feed additives as alternatives for an antibiotic growth promoter in broiler diets. British Poultry Science 44(1): S44– S45. https://doi.org/10.1080/713655288 DOI: https://doi.org/10.1080/713655288

Devegowda G. 1996. Herbal medicines, an untapped treasure in poultry production. Proc. 20th World Poult. Congr. New Delhi, India.

Durrani F R, Sultan A, Ahmed S, Chand N, Khattak F M and Durrani Z. 2007. Efficacy of aniseed extract as immune stimulant and growth promoter in broiler chicks. Pakistan Journal of Biological Sciences 10(20): 3718–21. http://dx.doi.org/10.3923/pjbs.2007.3718.3721 DOI: https://doi.org/10.3923/pjbs.2007.3718.3721

Eevuri T R and Putturu R. 2013. Use of certain herbal preparations in broiler feeds - A review, Veterinary World 6(3): 172–79. https://doi.org/10.5455/vetworld.2013.172-179 DOI: https://doi.org/10.5455/vetworld.2013.172-179

Elizabeth M, Thangavel A and Leela V. 2011. Effect of dietary supplementation of amla and grape seed powders on antioxidant status in the seminal plasma of broiler breeder cocks. Tamilnadu Journal of Veterinary and Animal Sciences 7(5): 229–33.

Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L and Cao Y. 2012. Allicin enhances host proinflammatory immune responses and protects against acute murine malaria infection. Malaria Journal 11(1): 268. https://doi.org/10.1186/1475-2875-11-268 DOI: https://doi.org/10.1186/1475-2875-11-268

Ferreira L A F, Henriques O B, Andreoni A A S, Vital G R F, Campos M, Habermehl G G and DeMoraes V L G. 1992. Antivenom and biological effects of ar-turmerone isolated from Curcuma longa (Zingiberaceae). Toxicon 30: 1211–18. https://doi.org/10.1016/0041-0101(92)90437-A DOI: https://doi.org/10.1016/0041-0101(92)90437-A

Gautam M, Diwanay S S, Gairola S, Shinde Y S, Jadhav S S and Patwardhan B K. 2004. Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. International Immunopharmacology. 4(6): 841–49. https://doi.org/10.1016/j.intimp.2004.03.005 DOI: https://doi.org/10.1016/j.intimp.2004.03.005

Goswami D, Mukherjee P K, Kar A, Ojha D, Roy S and Chattopadhyay D. 2016. Screening of ethnomedicinal plants of diverse culture for antiviral potentials. Indian Journal of Traditional Knowledge 15(3): 474–81.

Harris J C, Cottrell S, Plummer S and Lloyd D. 2001. Antimicrobial properties of Allium sativum (garlic). Applied Microbiology and Biotechnology 57(3): 282–86. https://doi.org/10.1007/s002530100722 DOI: https://doi.org/10.1007/s002530100722

Hashemi S R and Davoodi H. 2012 Herbal plants as new immunostimulator in poultry industry: A review. Asian Journal of Animal and Veterinary Advances 7: 105–16. https:// dx.doi.org/10.3923/ajava.2012.105.116 DOI: https://doi.org/10.3923/ajava.2012.105.116

Hashemi S R, Zulkifli I, Zunita Z and Somchit M N. 2008b. The effect of selected sterilization methods on antibacterial activity of aqueous extract of herbal plants. International Journal of Biological Sciences 8: 1072–76. https://dx.doi.org/10.3923/jbs.2008.1072.1076 DOI: https://doi.org/10.3923/jbs.2008.1072.1076

Jamroz D, Wiliczkiewicz A, Wertelecki T, Orda J and Skorupińska J. 2005. Use of active substances of plant origin in chicken diets based on maize and locally grown cereals. British poultry Science 46(4): 485–93. https://doi.org/10.1080/00071660500191056 DOI: https://doi.org/10.1080/00071660500191056

Jayaprakasha G K, Rao L J M and Sakariah K K. 2005. Chemistry and biological activities of C. longa. Trends in Food Science and Technology 16: 533–48. https://doi.org/10.1016/j.tifs.2005.08.006 DOI: https://doi.org/10.1016/j.tifs.2005.08.006

Jyotsana, Kumar P and Berwal R S. 2018. Supplementation of Ashwagandha root powder improving gut micro flora and immune response of broilers. The Pharma Innovation Journal 8(10): 114–18.

Kamat J P, Boloor K K, Devasagayam T P and Venkatachalam S R. 2000. Antioxidant properties of Asparagus racemosus against damage induced by γ-radiation in rat liver mitochondria. Journal of Ethnopharmacology 71(3): 425–35. https://doi. org/10.1016/S0378-8741(00)00176-8 DOI: https://doi.org/10.1016/S0378-8741(00)00176-8

Kannaki T R, Reddy M R, Verma P C and Shanmugam M. 2010. Chicken toll-like receptors and their role in immunity. World’s Poultry Science Association 66: 727–38. DOI: https://doi.org/10.1017/S0043933910000693

Khan R U, Naz S, Javdani M, Nikousefat Z, Selvaggi M, Tufarelli V and Laudadio V. 2012. The use of turmeric (Curcuma longa) in poultry feed. World’s Poultry Science Journal 68(1): 97– 103. https://doi.org/10.1017/S0043933912000104 DOI: https://doi.org/10.1017/S0043933912000104

Kim H J, Yokozawat, Kimhy, Tohda C, Rao T P and Juneja L R. 2005. Influence of Amla (Emblica Officinalis Gaertnl) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats. Journal of Nutritional Science and Vitaminology 51: 413–18. DOI: https://doi.org/10.3177/jnsv.51.413

Kirk C K. 1997. Interaction between Nutrition and Infections Disease Infectious Disease, pp. 73-74. Diseases of Poultry. (Ed) Calnek B W. Iowa State University Press, Ames, IA., USA.

Kiso Y, Suzuki Y, Oshima Y and Hikino H. 1983. Stereostructure of curlone, a sesquiterpenoid of Curcuma longa rhizomes. Phytochemistry 22(2): 596–97. https://doi.org/10.1016/0031- 9422(83)83057-X DOI: https://doi.org/10.1016/0031-9422(83)83057-X

Kumar R. 2019. ‘Comparative effect of shatavari, garlic, aloe vera and moringa on the performance of broilers fed with distillers dried grain with soluble (DDGS) based diet.’ M.V.Sc. Thesis submitted to LUVAS, Hisar.

Kumari P, Gupta M K, Ranjan R K, Singh K K and R Yadav. 2007. Curcuma longa as feed additive in broiler birds and its patho- physiological effects. Indian Journal of Experimental Biology 45(3): 272–77.

Lalla J K, Hamrapurkar P D and Mamania H M. 2001. Triphala churna from raw materials to finished products. Indian Drugs 38: 87–94.

Li Q, Wang G, Zhang M, Cuff C F, Huang L and Reed E. 2009. ß-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncology Reports 22(1): 161–70. http://doi.org/10.3892/or_00000420 DOI: https://doi.org/10.3892/or_00000420

Mahamood K, Yaqoob U. and Bajwa R. 2008. Antibacterial activity of essential oil of Ocimum sanctum (L). Mycopath. 6: 63–65.

Mahima, Rahal A, Deb R, Latheef S K, Samad H A, Tiwari R, Verma A K, Kumar A and Dhama K. 2012. Immunomodulatory and therapeutic potentials of herbal, traditional/indigenous and ethnovetrinary medicines. Pakistan Journal of Biological Sciences 15: 754–74. https://dx.doi.org/10.3923/pjbs.2012.754.774 DOI: https://doi.org/10.3923/pjbs.2012.754.774

Manish G, Diwanay S, Gairolac S, Shinde Y, Patki P and Patwardhan B. 2004. Immuno adjuvant potential of Asparagus racemosus. Journal of Ethnopharmacology 91(2-3): 251–55. https://doi.org/10.1016/j.jep.2003.12.023 DOI: https://doi.org/10.1016/j.jep.2003.12.023

Marcu. 2005. Moringa Oleifera Rural Communities A Tree Giving Life. National Agri Marketing Council, 466 Foothill Blvd. 251, La Canada, CA. 91011.

Mirzaei-Aghsaghali A. 2012. Importance of medical herbs in animal feeding: A review. Annals of Biological Research 3(2): 918–23.

Mmereole F U C. 2011. Evaluation of the dietary inclusion of Aloe vera as an alternative to antibiotic growth promoter in broiler production. Pakistan Journal of Nutrition 10(1): 1–5. http://dx.doi.org/10.3923/pjn.2011.1.5 DOI: https://doi.org/10.3923/pjn.2011.1.5

Mondal S, Varma S, Bamola V D, Naik S N, Mirdha B R, Padhi M M and et al. 2011. Double-blinded randomized controlled trial for immunomodulatory effects of tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of Ethnopharmacology 136(3): 452–56. http://dx.doi.org/10.1016/j.jep.2011.05.012 DOI: https://doi.org/10.1016/j.jep.2011.05.012

Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M and et al. 2005. Curcuminoids and sesquiterpenoids in Turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. Journal of Agricultural and Food Chemistry 53: 959–63. https://doi.org/10.1021/jf0483873 DOI: https://doi.org/10.1021/jf0483873

Osawa T, Sugiyama Y, Inayoshi M and Kawakishi S. 1995. Anti-oxidative activity of tetrahydrocurcuminoids. Bioscience, Biotechnology and Biochemistry 59(9): 1609–12. https://doi.org/10.1271/bbb.59.1609 DOI: https://doi.org/10.1271/bbb.59.1609

Padalia R C and Verma R S. 2011. Comparative volatile oil composition of four Ocimum species from northern India. Natural Product Research 25(6): 569–75. https://doi.org/10.1080/14786419.2010.482936 DOI: https://doi.org/10.1080/14786419.2010.482936

Pathmanathan M K, Uthayarasa K, Jeyadevan J P and Jeyaseelan E C. 2010. In vitro antibacterial activity and phytochemical analysis of some selected medicinal plants. International Journal of Pharmaceutical and Biological Archives 1(3): 291–99.

Piper J T, Singhal S S, Salameh M S, Torman R T, Awasthi Y C and Awasthi S. 1998. Mechanisms of anticarcinogenic properties of curcumin: The effect of curcumin on glutathione linked detoxification enzymes in rat liver. International Journal of Biochemistry and Cell Biology 30(4): 445–56. http://dx.doi. org/10.1016/S1357-2725(98)00015-6 DOI: https://doi.org/10.1016/S1357-2725(98)00015-6

Prakash P and Gupta N. 2005. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on Eugenol and its pharmacological actions: A short review. Indian Journal of Physiology and Pharmacology 49(2): 125–31.

Priya K T, Thangavel A, Leela V. 2010. Antioxidant status in broiler breeder cocks supplemented with amla (Emblica officinalis) and grape (Vites venifera) seed. Tamilnadu Journal of Veterinary and Animal Sciences 6(1): 1923.

Rahimi S, Zadeh Z T, Torshizi M A K, Omidbaigi R, and Rokni H. 2011. Effect of the three herbal extracts on growth performance,immune system, blood factors and intestinal selected bacterial population in broiler chickens. Journal of Agricultural Science and Technology 13: 527–39.

Ram S, Neetu D, Deepti P, Vandana M, Ilavazhagan G and Kumar D. 2003. Cytoprotective activity of Amla (Emblica officinalis) against chromicum (VI) induced oxidative injury in murine macrophages. Phytotherapy Research 17: 430–33. http://dx.doi.org/10.1002/ptr.1157 DOI: https://doi.org/10.1002/ptr.1157

Rehman H U, Yasin K A and Choudhary M A. 2007. Studies on the chemical constituents of Phyllanthus emblic. Natural Product Research. 21(9): 775–81. http://dx.doi.org/10.1080/14786410601124664 DOI: https://doi.org/10.1080/14786410601124664

Ruby A J, Kuttan G, Babu K D, Rajasekharan K N and Kuttan R. 1995. Antitumor and antioxidant activity of natural curcuminoids. Cancer Letters 94(1): 79–83. https://doi.org/10.1016/0304-3835(95)03827-j DOI: https://doi.org/10.1016/0304-3835(95)03827-J

Safameher A, Mirahmadi M and Nobakht A. 2012. Effect of nettle (Urtica dioica) medicinal plant on growth performance, immune responses, and serum biochemical parameters of broiler chickens. International Research Journal of Applied and Basic Sciences 3(4): 721–28.

Saini A, Sharma S and Chhibber S. 2008. Protective efficacy of Emblica officinalis against Klebsiella pneumoniae induced pneumonia in mice. Indian Journal of Medical Research 128(2): 188–93.

Savage T F, Cotter P F and Zakrzewska E I. 1996. The effect of feeding mannan oligosaccharide on immunoglobulins, plasma IgG and bile IgA of Wrolstad MW male turkeys. Poultry Science 75(1): 143.

Seena K, Kuttan G and Kuttan R. 1993. Antitumour activity of selected plant extracts. Amala Research Bulletin 13: 41–45.

Senthilnathan P, Padmavathi R, Banu S M and Sakthisekaran D. 2006. Enhancement of antitumor effect of paclitaxel in combination benzopyrene induced experimental lung cancer. Chemico-Biological Interaction 159(3): 180–85. https://doi.org/10.1016/j.cbi.2005.11.003 DOI: https://doi.org/10.1016/j.cbi.2005.11.003

Sheoran N, Kumar R, Kumar A, Batra K, Sihag S, Maan S and Maan N S. 2017. Nutrigenomic evaluation of garlic (Allium sativum) and holy basil (Ocimum sanctum) leaf powder supplementation on growth performance and immune characteristics in broilers. Veterinary World 10(1): 121–29. http://dx.doi.org/10.14202/vetworld.2017.121-129 DOI: https://doi.org/10.14202/vetworld.2017.121-129

Siddhuraju P and Becker K. 2003. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. Journal of Agricultural and Food Chemistry 51(8): 2144–55. https://doi.org/10.1021/jf020444 DOI: https://doi.org/10.1021/jf020444+

Siddiqui M N, Islam M T, Sayed M A and Hossain M A. 2015. Effect of dietary supplementation of acetone extracts of Nigella sativa L. seeds on serum cholesterol and pathogenic intestinal bacterial count in broilers. Journal of Animal and Plant Sciences. 25(2): 372–79.

Singh S. 2018. ‘Effect of dietary supplementation of giloy (Tinospora cordifolia) powder on the performance of broilers.’ M.V.Sc. Thesis submitted to LUVAS, Hisar.

Sinha K, Mishra N P, Singh J and Khanuja S P S. 2004. “Tinospora cordifolia” - Plant for therapeutic applications: A review. Indian Journal of Traditional Knowledge 3(3): 257–70.

Smith R M and Robinson J M. 1981. The essential oil of ginger from Fiji. Phytochemistry 20(2): 203–06. https://doi.org/10.1016/0031-9422(81)85093-5 DOI: https://doi.org/10.1016/0031-9422(81)85093-5

Takeda K and Akira S. 2005. Toll-like receptors in innate immunity. International Immunology. 17: 1–14. https://doi.org/10.1093/intimm/dxh186 DOI: https://doi.org/10.1093/intimm/dxh186

Teixeira E M B, Carvalho M R B, Neves V A, Silva M A, Arantes- Pereira L. 2014. Chemical characteristics and fractionation of proteins from Moringa oleifera Lam. leaves. Food Chemistry 147: 51–54. https://doi.org/10.1016/j.foodchem.2013.09.135 DOI: https://doi.org/10.1016/j.foodchem.2013.09.135

Toennesen H H. 1992. Chemistry of curcumin and curcuminoids. (Eds) Ho C T, Lee C and Huang M T. Phenolic Compounds in Food and their Effect of Health. 1: Analysis, Occurrence and Chemistry. ACS Symposium Series No. 506. Washington, DC (USA): American Chemical Society. pp. 143-153. DOI: https://doi.org/10.1021/bk-1992-0506.ch011

Toghyani M, Toghyani M, Gheisari A A, Ghalamkari G. and Eghbalsaeid S. 2011. Evaluation of cinnamon and garlic as antibiotic growth promoter substitutions on performance, immune responses, serum biochemical and haematological parameters in broiler chicks. Livestock Science 138(1-3): 167– 73. https://doi.org/10.1016/j.livsci.2010.12.018 DOI: https://doi.org/10.1016/j.livsci.2010.12.018

Underhill D. and Ozinsky A. 2002. Toll-like receptors: Key mediators of microbe detection. Current Opinion in Immunology 14: 103–10. http://dx.doi.org/10.1016/S0952-7915(01)00304-1 DOI: https://doi.org/10.1016/S0952-7915(01)00304-1

William P and Losa R. 2001. The Use of Essential Oils and Their Compounds in Poultry Nutrition. World’s Poultry 17(4): 14–15.

Yarru L P, Settivari R S, Gowda N K S, Antoniou E, Ledoux D R and Rottinghaus G E. 2009. Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poultry Science 88(12): 2620–27. https://doi.org/10.3382/ps.2009-00204 DOI: https://doi.org/10.3382/ps.2009-00204

Zhao T F, Wang X, Rimando A M and Che C. 1991. Folkloric medicinal plants: Tinospora sagittata var. Cravaniana and Mahonia bealei. Planta Medica 57(5): 505. https://doi.org/10.1055/s-2006-960188 DOI: https://doi.org/10.1055/s-2006-960188