Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo

RAJNI KUMARI; SHANKER DAYAL; ROHAN KUMAR RAMAN; P C CHANDRAN; SANJAY KUMAR; PRADEEP KUMAR RAY; REENA KAMAL; JYOTI KUMAR; AMITAVA DEY; KAMAL SARMA; UJJWAL KUMAR

doi:10.56093/ijans.v92i10.125604

Authors

RAJNI KUMARI ICAR Research Complex for Eastern Region, Patna, Bihar
SHANKER DAYAL ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
ROHAN KUMAR RAMAN ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
P C CHANDRAN ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
SANJAY KUMAR Bihar Veterinary College, Patna, Bihar
PRADEEP KUMAR RAY ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
REENA KAMAL ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
JYOTI KUMAR ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
AMITAVA DEY ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
KAMAL SARMA ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India
UJJWAL KUMAR ICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India

https://doi.org/10.56093/ijans.v92i10.125604

Keywords:

Buffalo, Chemokines, Embryo maternal signaling, Early embryonic losses, ISGs

Abstract

Successful pregnancy establishment has a major influence on reproductive efficiencies of dairy buffaloes. This success depends on coordinated communications between conceptus and maternally derived cells, and any disturbance in this communication network during this process leads to early embryonic losses. Since, early embryonic losses is one of the prime cause of pregnancy failure in dairy buffaloes, present investigation was aimed to understand the expression dynamics and correlation pattern of Interferon tau stimulated genes and chemokines during peri-implantation period in dairy buffaloes through transcriptional profiling followed by Principal Component Analysis. Our study revealed upregulation of all the candidate genes in maternal whole blood across the parity, emphasizing the involvement of immune responses as signatures for healthy pregnancy. Understanding these embryo-maternal communication signals offers potential to prevent incidences of early embryonic losses and can provide insights on possible targets for therapy too.

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