Comparison of the sedative and analgesic effects of butorphanol with acepromazine, midazolam, or dexmedetomidine following propofol induction and isoflurane maintenance in canines


Abstract views: 68 / PDF downloads: 65

Authors

  • RAJESH KUMAR Department of Veterinary Surgery, Bihar Veterinary College, Patna, Bihar https://orcid.org/0000-0002-4644-4470
  • AAKANKSHA ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122 India
  • ARCHANA KUMARI Department of Veterinary Surgery, Bihar Veterinary College, Patna, Bihar
  • N K VERMA ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122 India
  • A C SAXENA ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122 India
  • M HOQUE ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122 India

https://doi.org/10.56093/ijans.v92i11.127068

Keywords:

Acepromazine, Analgesia, Dexmedetomidine, Midazolam, Pain Score, Sedation

Abstract

Adequate sedation and excellent depth of analgesia were recorded in all the four groups after induction to the end of surgical procedure, however, significantly higher sedation score and depth of analgesia were observed in group D and significantly lower was observed in group A in comparison to other groups. Butorphanol with acepromazine, midazolam, or dexmedetomidine provides adequate sedation and analgesia in the dogs, before induction with propofol, so it made handling of the animals proper and safe before induction. Dexmedetomidine produces most profound sedation and analgesia followed by midazolam and acepromazine along with butorphanol.

Downloads

Download data is not yet available.

References

Ahmad R A, Kinjavdekar P, Aithal H P, Pawde A M and Kumar D. 2013. Potential use of dexmedetomidine for different levels of sedation, analgesia and anaesthesia in dogs. Veterinarni Medicina 58(2): 87–95. DOI: https://doi.org/10.17221/6699-VETMED

Bednarski R, Grimm K, Harvey R, Lukasik V M, Penn W S, Sargent B and Spelts K. 2011. AAHA anesthesia guidelines for dogs and cats. Journal of the American Animal Hospital Association 47(6): 377–85. DOI: https://doi.org/10.5326/JAAHA-MS-5846

Bigby S E, Beths T, Bauquier S and Carter J E. 2017. Post- induction apnoea in dogs pre-medicated with acepromazine or dexmedetomidine and anaesthetized with alfaxalone or propofol. Veterinary Anaesthesia and Analgesia 44(5): 1007– 15. DOI: https://doi.org/10.1016/j.vaa.2016.10.004

Bufalari A, Miller S M, Short C E and Giannoni G. 1997. The use of propofol for induction of anaesthesia in dogs pre- medicated with acepromazine, butorphanol and acepromazine- butorphanol. New Zealand Veterinary Journal 45(4): 129–34. DOI: https://doi.org/10.1080/00480169.1997.36012

Canfran S, Bustamante R, González P, Cediel R Re M and de Segura I G. 2016. Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam. Veterinary Journal 210: 56–60. DOI: https://doi.org/10.1016/j.tvjl.2016.01.015

Carregaro A B, Ueda G I, Censoni J B, Bisetto S P, Alonso B B and Reginato G M. 2020. Effect of methadone combined with acepromazine or detomidine on sedation and dissociative anesthesia in healthy horses. Journal of Equine Veterinary Science 86: 102908. DOI: https://doi.org/10.1016/j.jevs.2019.102908

Commiskey S, Fan L W, Ho K and Rockhold, R W. 2005. Butorphanol: Effects of a prototypical agonist-antagonist analgesic on κ-opioid receptors, Journal of Pharmacological Sciences 98(2): 109–16. DOI: https://doi.org/10.1254/jphs.CRJ05001X

Correa-Sales C, Rabin B C and Maze M. 1992. A hypnotic response to dexmedetomidine, an alpha-2 agonist, is mediated in the locus coeruleus in rats. Anaesthesiology 76(6): 948–52. DOI: https://doi.org/10.1097/00000542-199206000-00013

Costa G P, Monteiro E R, Marques É J, Beck R C, Carneiro R K, da Costa F V and Valle S F. 2021. Sedative effects of acepromazine in combination with nalbuphine or butorphanol, intramuscularly or intravenously, in healthy cats: A randomized, blinded clinical trial. Journal of Feline Medicine and Surgery 23(6): 540–48. DOI: https://doi.org/10.1177/1098612X20962754

Daabiss M. 2011. American Society of Anaesthesiology : Physical status classification. Indian Journal of Anaethesia 55(2): 111. DOI: https://doi.org/10.4103/0019-5049.79879

Granholm M, McKusick B C, Westerholm F C and Aspegrén J C. 2007. Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. Veterinary Record 160(26): 891–97. DOI: https://doi.org/10.1136/vr.160.26.891

Honkavaara J M, Raekallio M R, Kuusela E K, Hyvärinen E A and Vainio O M. 2008. The effects of L-659,066, a peripheral alpha-2 adrenoceptor antagonist, on dexmedetomidine- induced sedation and bradycardia in dogs. Veterinary Anaesthesia and Analgesia 35(5): 409–13. DOI: https://doi.org/10.1111/j.1467-2995.2008.00403.x

Hopkins A, Giuffrida M and Larenza M P. 2014. Midazolam, as a co induction agent, has propofol sparing effects but also decreases systolic blood pressure in healthy dogs. Veterinary Anaesthesia and Analgesia 41(1): 64–72. DOI: https://doi.org/10.1111/vaa.12088

Kumar R, Aakanksha A K, Verma N K, Saxena A C and Hoque M. 2020. Systemic effects and clinical application of dexmedetomidine. The Pharma Innovation Journal 9(11): 241–46. DOI: https://doi.org/10.22271/tpi.2020.v9.i11d.5344

Kojima K, Nishimura R, Mutoh T, Takao K, Matsunaga S, Mochizuki M and Sasaki N. 1999. Comparison of sedative effects of medetomidine midazolam, acepromazine, butorphanol and midazolam butorphanol in dogs. Journal of Veterinary Medicine Series A 46(3): 141–48. DOI: https://doi.org/10.1046/j.1439-0442.1999.00194.x

Monteiro E R, Junior A R, Assis H M Q, Campagnol D and Quitzan J G. 2009. Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol in combination with acepromazine in dogs. Veterinary Anaesthesia and Analgesia 36(1): 25–33. DOI: https://doi.org/10.1111/j.1467-2995.2008.00424.x

Murrell J C. 2007. Choice of premedicants in cats and dogs. In Practice 29(2): 100–06. DOI: https://doi.org/10.1136/inpract.29.2.100

Murrell J C and Hellebrekers L J. 2005. Medetomidine and dexmedetomidine: Areview of cardiovascular effects and antinociceptive properties in the dog. Veterinary Anaesthesia and Analgesia 32(3): 117–27. DOI: https://doi.org/10.1111/j.1467-2995.2005.00233.x

National Office of Animal Health. 2010. Torbugesic 1% w/v Solution for Injection: Dosage and administration.

Pypendop B H, Honkavaara J and Ilkiw J E. 2017. Cardiovascular effects of dexme- detomidine, with or without MK-467, following intravenous administration in cats. Veterinary Anaesthesia and Analgesia 44(1): 52–62. DOI: https://doi.org/10.1111/vaa.12397

Sano T, Nishimura R, Mochizuki M and Sasaki N. 2003. Effects of midazolam- butorphanol, acepromazine-butorphanol and medetomidine on an induction dose of propofol and their compatibility in dogs. Journal of Veterinary Medical Science 65(10): 1141–43. DOI: https://doi.org/10.1292/jvms.65.1141

Shirasaka T, Hiroshi K and Mayumi T. 2007. Activation of a G protein–coupled inwardly rectifying K+ current and suppression of I h contribute to dexmedetomidine- induced inhibition of rat hypothalamic paraventricular nucleus neurons. The Journal of the American Society of Anesthesiologists 107(4): 605–15. DOI: https://doi.org/10.1097/01.anes.0000281916.65365.4e

Tranquilli W J, Thurmon J C and Grimm K A. 2013. Lumb and Jones’ Veterinary Anesthesia and Analgesia. John Wiley and Sons.

Wagner M C, Hecker K G and Pang D S. 2017. Sedation levels in dogs: A validation study. BMC Veterinary Research 13(1): 1–8. DOI: https://doi.org/10.1186/s12917-017-1027-2

Wang J, Sun P and Liang P. 2020. Neuropsychopharmacological effects of midazolam on the human brain. Brain Informatics 7(1): 1–12. DOI: https://doi.org/10.1186/s40708-020-00116-y

Downloads

Submitted

2022-08-19

Published

2022-11-09

How to Cite

KUMAR, R., AAKANKSHA, KUMARI, A., VERMA, N. K., SAXENA, A. C., & HOQUE, M. (2022). Comparison of the sedative and analgesic effects of butorphanol with acepromazine, midazolam, or dexmedetomidine following propofol induction and isoflurane maintenance in canines. The Indian Journal of Animal Sciences, 92(11), 1285–1288. https://doi.org/10.56093/ijans.v92i11.127068

Issue

Section

Short-Communication
Citation