Effect of Zinc supplementation on haematology, oxidative stress and plasma biochemical parameters in cadmium exposed goats


196 / 247

Authors

  • SANKAR V Tamil Nadu Veterinary and Animal Science University, Tamil Nadu
  • VEENA MANI National Dairy Research Institute, Karnal, Haryana
  • TAPAN KUMAR DAS College of Veterinary Sciences and Animal Husbandry, R.K. Nagar, West Tripura
  • HARJIT KAUR National Dairy Research Institute, Karnal, Haryana
  • NEELAM KEWALRAMANI National Dairy Research Institute, Karnal, Haryana

https://doi.org/10.56093/ijans.v93i11.128862

Keywords:

Catalase, Glucose, SOD, Total immunoglobulin, Total antioxidant activity

Abstract

The present study was designed to assess the effect of zinc supplementation on haematology, oxidative stress and plasma biochemical parameters in Cd induced lactating goats. Eighteen crossbred lactating goats were divided into three groups (Control, T1 and T2). In T1 and T2 groups, goats were given 10 ppm Cdcl2, while in T2, Zinc @100ppm was also supplemented for period of 120 days. At the end of study, blood glucose, TLC, neutrophil % and AST, ALT were increased significantly in T1 group and except glucose, Zn supplementation in T2 group showed its protective effect on TLC, neutrophil %, lymphocyte %, AST and ALT. There was significant decrease in lymphocyte %, Hb and plasma total antioxidant activity in T1 group. At 30 days, the activity of SOD was increased in T1 and T2 but thereafter activities were significantly decreased at 120 days in T1 but in T2 it was similar to control. The activity of catalase was increased on 30 and 60 days and thereafter decreased from 90 days onwards but the rate of decline was comparatively less in T2. Total immunoglobulin and lymphocyte stimulation index were significantly decreased in T1 group whereas in Zn supplemented group decline trend was less. Henceforth, it was concluded that 100 ppm Zn is helpful in reducing burden of Cd induced biochemical and oxidative stress in goats.

Downloads

Download data is not yet available.

References

Aebi H.1984. Catalase in vitro, pp. 121–26. Methods in Enzymology. (Ed) Packer L, New York. DOI: https://doi.org/10.1016/S0076-6879(84)05016-3

Amara S, Abdelmelek H, Garrel C, Guiraud P, Douki T, Ravanatalain J L, Favier A, Sakly M and Rhouma K B. 2008. Preventive effect of zinc against cd-induced oxidative stress in the rat testis. Journal of Reproduction and Development 54: 129–34. DOI: https://doi.org/10.1262/jrd.18110

Bartoskewitz M L, Hewitt D G, Laurenz J C, Pitts J S and Bryant F C. 2007. Effect of dietary copper and zinc concentrations on white-tailed deer antler growth, body size, and immune system function. Small Ruminant Research 73: 87–94. DOI: https://doi.org/10.1016/j.smallrumres.2006.11.005

Bayoumi Y H. 2013. ‘Assessment of the impact of environmental pollution with heavy metals on sheep reared at Bahr El Bakar region.’ PhD Thesis. Faculty of Veterinary Sciences, Zagazig University.

Benzie E F I and Strain J J. 1999. Ferric reducing antioxidant power assay: Direct measurement of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant and ascorbic acid concentration. Methods in Enzymology 299: 15–27. DOI: https://doi.org/10.1016/S0076-6879(99)99005-5

Bose. 1999. ‘Toxico and immunopathological effects of induced chronic Cd intoxication in goats.’ M.V.Sc. Thesis, West Bengal University of Animal and Fishery Sciences, Calcutta, India.

Cai Q, Long M L, Zhu M, Zhou Q Z, Zhang L and Liu J. 2009. Food chain transfer of cadmium and lead to cattle in a lead- zinc smelter in Guizhou, China. Environmental Pollution 57(1): 3078–82. DOI: https://doi.org/10.1016/j.envpol.2009.05.048

Chauhan R S and Agrawal D K. 1999. Immunopathology of Cd in bovine calves. Journal of Immunology and Immunopathology 1: 31–34.

Drabkin D L. 1944. Photometry and spectrometry: Medical physics, Vol. 1. Year Book Medical Publishers Inc., Chicago.

El Demerdash F M, Yousef M I, Kedwany F S and Baghdadi H H. 2004. Cd-induced changes in lipid peroxidation, blood haematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food and Chemical Toxicology 40: 1563–71. DOI: https://doi.org/10.1016/j.fct.2004.05.001

Erdogan Z, Erdogan S, Celik S and Unlu A. 2005. Effects of ascorbic acid on Cd-induced oxidative stress and performance of broilers. Biological Trace Element Research 104: 19–32. DOI: https://doi.org/10.1385/BTER:104:1:019

Fitzgerald P R, Peterson J and Lue Hing C. 1985. Heavy metals in tissues of cattle exposed to sludge-treated pastures for eight years. American Journal of Veterinary Research 46: 703–07.

Guilhermino L, Soares A M V M, Carvalho A P and Lopes M C. 1998. Effects of Cd and Parathion exposure on haematology and blood biochemistry of adult male rats. Bulletin of Environmental Contamination and Toxicology 60: 52–59. DOI: https://doi.org/10.1007/s001289900590

Han X, Xu Z, Wang V and Huang G. 2005. Effect of cadmium on lipid peroxidation and activities of antioxidant enzymes in growing pigs. Biological Trace Element Research 110: 251–63. DOI: https://doi.org/10.1385/BTER:110:3:251

Hayat M T, Nauman M, Nazir N, Ali S and Bangash N. 2019. In: Cadmium toxicity and tolerance in plants, pp. 163–83. Environmental Hazards of Cadmium: Past, Present, and Future. (Ed) Mirza H. Elsevier. DOI: https://doi.org/10.1016/B978-0-12-814864-8.00007-3

Hooser S B. 2018. Cadmium, pp. 417–421. Veterinary Toxicology. Academic Press. DOI: https://doi.org/10.1016/B978-0-12-811410-0.00024-6

Khan M A, Khan S, Khan A and Alam M. 2017. Soil contamination with cadmium, consequences and remediation using organic amendments. Science of The Total Environment 601-602: 1591–1605. DOI: https://doi.org/10.1016/j.scitotenv.2017.06.030

Kundu M S. 1993. ‘Dietary zinc and copper levels influencing immune status of calves.’ Ph D. Thesis., National Dairy Research Institute (Deemed University), Karnal, India.

Lafuente A, Gonz´alez Carracedo A and Esquifino A I. 2004. Differential effects of Cd on blood lymphocyte subsets. Biometals 17: 451–56. DOI: https://doi.org/10.1023/B:BIOM.0000029441.20037.72

Lisic R C, Sarras M P, Hidalgo J and Andrews G K. 1996. Metallothioncin is a component of exocrine pancreas secretion: implications for zinc homeostasis. American Journal of Physiology-Cell Physiology 271: C2204–C1110. DOI: https://doi.org/10.1152/ajpcell.1996.271.4.C1103

Marklund S and Marklund S. 1974. Involvement of superoxide dismutase anion radical in autoxidation of pyrogallol and a convenient assay for Superoxide dismutase. European Journal of Biochemistry 42: 469. DOI: https://doi.org/10.1111/j.1432-1033.1974.tb03714.x

Mladenovic J, Ognjanovic B, Dordevic N, Matic M, Knezˇevic V, Stajn A and Saicˇic Z. 2014. Protective effects of oestradiol against cadmium-induced changes in blood parameters and oxidative damage in rats. Archives of Industrial Hygiene and Toxicology 65: 37–46. DOI: https://doi.org/10.2478/10004-1254-65-2014-2405

McDowell L R. 1992. Minerals in Animal and Human Nutrition. pp. 359–61. Academic Press, New York.

Mc Ewan A D and Fisher E W. 1970. A turbidity test for the estimation of immunoglobulins levels in neonatal calf serum. Clinica Chimica Acta 17: 155. DOI: https://doi.org/10.1016/0009-8981(70)90390-6

Morsy M M, El Ghannam A A and Saleh S Y. 2020. Assessment of serum mineral concentrations of barki sheep and its impact on kidney functions in El-Hammam city. Advances in Animal and Veterinary Sciences 8: 68–75.

Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65: 55–63. DOI: https://doi.org/10.1016/0022-1759(83)90303-4

NRC. 1981. Nutrient requirements of goats: Angora, dairy and meat goats in temperate and tropical countries. National Academy Press, Washington, D.C.

NRC. 2007. Nutrient requirements of small ruminants: Sheep, goats, cervids and new world camelids. National Academy Press, Washington, DC.

Oraby M I, Rakha G H and Elsayed A A. 2015. ‘Some studies on effect of drainage water on sheep health.’ M.Sc. Thesis. Faculty of Veterinary Medicine, Cairo University, Egypt.

Orabi M I, Baraka T A and Rakha G H. 2021. Impact of cadmium intoxication on health status, rumen and blood constituents in Egyptian Ossimi Sheep. International Journal of Veterinary Sciences 10: 102–06. DOI: https://doi.org/10.47278/journal.ijvs/2021.040

Patel A K, Kewalramani N, Mani V and Kaur H. 2009. Effect of vitamin E supplementation in growing kids fed on arsenic containing diet. Indian Journal of Animal Nutrition 26: 9–16.

Patra R C, Swarup D, Naresh R, Kumar P and Nandi D. 2007. Tail hair as an indicator of environmental exposure of cows to lead and cadmium in different industrial areas. Ecotoxicology and Environmental Safety 66: 127–31. DOI: https://doi.org/10.1016/j.ecoenv.2006.01.005

Pi J, Yamauchi H and Kumagai Y. 2002. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environmental Health Perspective 110: 331–36. DOI: https://doi.org/10.1289/ehp.02110331

Rahimzadeh M R, Rahimzadeh M R, Kazemi S and Moghadamnia A A. 2017. Cadmium toxicity and treatment: An update. Caspian Journal of Internal Medicine 8: 135–45.

Reddy C S and Dorn C R. 1985. Municipal sewage sludge application on Ohio farms: Estimation of cadmium intake. Environmental Research 38: 377–88. DOI: https://doi.org/10.1016/0013-9351(85)90099-4

Stoev S D, Grozeva N, Simeonov R, Borisov I, Hubenov H, Nikolov Y, Tsaneva M and Lazarova, S. 2003. Experimental cadmium poisoning in sheep. Experimental and Toxicologic Pathology 55: 309–14. DOI: https://doi.org/10.1078/0940-2993-00333

Underwood E J and Suttle N F. 2001. Essentially toxic elements (aluminium, arsenic, cadmium, fluorine, lead, mercury), pp.543–586. The Mineral Nutrition of Livestock. (Eds) E J Underwood and N F Suttle . CABI Publishing, New York, USA. DOI: https://doi.org/10.1079/9780851991283.0543

Downloads

Submitted

2022-10-07

Published

2023-10-31

Issue

Section

Articles

How to Cite

V, S., MANI, V., DAS, T. K., KAUR, H., & KEWALRAMANI, N. (2023). Effect of Zinc supplementation on haematology, oxidative stress and plasma biochemical parameters in cadmium exposed goats. The Indian Journal of Animal Sciences, 93(11), 1077–1082. https://doi.org/10.56093/ijans.v93i11.128862
Citation