Comparative evaluation of valethamate bromide and hyoscine butyl bromide on cervical dilatation in water buffaloes after detorsion

RISHIPAL YADAV; GYAN SINGH; POOJA YADAV; PRADEEP DANGI; ANKIT MAGOTRA; RAKESH MALIK; DEVENDER BIDHAN; MANEESH SHARMA; SANDEEP KUMAR; TARUN KUMAR

doi:10.56093/ijans.v93i3.131037

Authors

RISHIPAL YADAV Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
GYAN SINGH Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
POOJA YADAV Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
PRADEEP DANGI Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
ANKIT MAGOTRA Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
RAKESH MALIK Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
DEVENDER BIDHAN Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
MANEESH SHARMA Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
SANDEEP KUMAR Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India
TARUN KUMAR Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004 India

https://doi.org/10.56093/ijans.v93i3.131037

Keywords:

Buffaloes, Cervix, Hyoscine butyl bromide, Torsion, Valethamate bromide

Abstract

After detorsion, incomplete cervical dilatation is major cause of dystocia. The present study aimed to investigate the comparative efficacy of valethamate bromide and hyoscine butyl bromide on cervical dilation after detorsion and their effect on haematological and biochemical parameters of torsion detorted water buffaloes. A total of 18 buffaloes were selected for study which were divided into three groups of six animals each. After detorsion by Sharma’s Modified Schaffer’s method, animals with grade I and grade II cervix were selected for the study. Group I (control group) buffaloes were administered with dexamethasone (40 mg, I/M), cloprostenol (500 μg, I/M) and mifex (450 mL, slow I/V) after successful detorsion. Along with these drugs, in group II and group III, valethamate bromide (100 mg, I/M) and hyoscine butyl bromide (160 mg, I/M) were administered, respectively. The cervical dilation rate (CDR) of each group was calculated and compared. Blood samples were collected three times: before detorsion, after treatment and at parturition. Group III (2.17±0.07 cm/h) had significantly higher CDR followed by group II (1.39±0.21 cm/h), and control group (0.47±0.19 cm/h). Serum calcium levels were also elevated after treatment. Both drug combinations were found safe haematologically and biochemically.

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References

Aalberts M, van Dissel-Emiliani F M, van Tol T A, Taverne M A and Breeveld-Dwarkasing V N. 2007. High iNOS mRNA and protein levels during early third trimester suggest a role for NO in prelabor cervical ripening in the bovine. Molecular Reproduction and Development 74: 378–85. DOI: https://doi.org/10.1002/mrd.20546

Aggarwal P, Zutshi V and Batra S. 2008. Role of hyoscine N-butyl bromide (HBB, buscopan®) as labor analgesic. Indian Journal of Medical Sciences 62(5): 179–84. DOI: https://doi.org/10.4103/0019-5359.40982

Ali A, Derar R, Hussein H A, AbdEllah M R and Abdel-Razek A K. 2011. Clinical, hematological, and biochemical findings of uterine torsion in buffaloes (Bubalus bubalis). Animal Reproduction Science 126(3-4): 168–72. DOI: https://doi.org/10.1016/j.anireprosci.2011.05.005

Amer H A and Hashem M A. 2008. Relationship between clinical and biochemical picture of uterine torsion in Egyptian buffaloes (Bubalus bubalis). Internet Journal of Veterinary Medicine 4(1): 1–11. DOI: https://doi.org/10.5580/1157

Amin S M, Amer H A, Hussein A E and Hazzaa A M. 2011. Creatine phosphokinase and aspartate aminotransverase profiles and its relation to the severity of uterine torsion in Egyptian buffalo. Animal Reproduction Science 123: 163–68. DOI: https://doi.org/10.1016/j.anireprosci.2010.12.002

Aubry P, Warnick L D, DesCôteaux L and Bouchard É. 2008. A study of 55 field cases of uterine torsion in dairy cattle. Canadian Veterinary Journal 49(4): 366–72.

Breeveld-Dwarkasing V N, Koppele J M, Bank R A, Van Der Weijden G C, Taverne M A and Van Dissel-Emiliani F M. 2003.Changes in water content, collagen degradation, collagen content, and concentration in repeated biopsies of the cervix of pregnant cows. Biology of Reproduction 69: 1608– 14. DOI: https://doi.org/10.1095/biolreprod.102.012534

Breeveld-Dwarkasing V N, Weijden G C, Taverne M A and Dissel Emiliani F M. 2000. The bovine cervix during the oestrous cycle: Regional differences in morphology and density of steroid hormone receptors. Reproduction in Domestic Animals 35: 120–24. DOI: https://doi.org/10.1046/j.1439-0531.2000.d01-4.x

Brenda T, Meredith A and Mala M. 2010. Cervical remodeling during pregnancy and parturition. Trends in Endocrinology and Metabolism 21: 353–61. DOI: https://doi.org/10.1016/j.tem.2010.01.011

Davies J V and Gerring E L. 1983. Effects of spasmolytic analgesic drugs on the motility patterns of the equine small intestine. Research in Veterinary Science 34: 334–39. DOI: https://doi.org/10.1016/S0034-5288(18)32233-1

Drost M. 2007. Complications during gestation in the cow. Theriogenology 68(3): 487–91. DOI: https://doi.org/10.1016/j.theriogenology.2007.04.023

Dwivedi A D, Rai G and Sharda S. 1999. Valethemate bromide and cervical dilatation. Medical Journal of Armed Forces India 55(3): 201–02. DOI: https://doi.org/10.1016/S0377-1237(17)30441-0

Ghuman S P S. 2010. Uterine torsion in bovines: A review. Indian Journal of Animal Sciences 80: 289–05.

Hadadian S and Fallahian M. 2016. Assessing the efficacy of vaginal hyoscine butyl bromide on cervical ripening prior to intrauterine procedures: A double-blinded clinical trial. International Journal of Reproductive BioMedicine 14(11): 709–12. DOI: https://doi.org/10.29252/ijrm.14.11.709

Hafez E S E. 1973. The comparitive anatomy of the mammalian cervix. The Biology of the Cervix. (Eds) Blandau R J and Moghissi K. The University of Chicago Press, Chicago, 23–56.

Hussein H A. 2013. Validation of color Doppler ultrasonography for evaluating the uterine blood flow and perfusion during late normal pregnancy and uterine torsion in buffaloes. Theriogenology 79(7): 1045–53. DOI: https://doi.org/10.1016/j.theriogenology.2013.01.021

Jeengar K, Choudhary V, Maharia S, Vivekanand and Purohit G N. 2015. A retrospective study on type and extent of uterine torsion in buffaloes. Research Journal for Veterinary Practitioners 3(1): 25–28. DOI: https://doi.org/10.14737/journal.rjvp/2015/3.1.25.28

Mahmoud E A, Essawi W M and Neamat-Allah A N F. 2020. Influence of uterine torsion in water buffaloes (Bubalus bubalis) with insights into the hematological and biochemical prognostic values regarding to manual correction. Tropical Animal Health and Production 52: 3165–71. DOI: https://doi.org/10.1007/s11250-020-02342-2

Maria A. 2014. Effect of rectal Hyoscine Butylbromide suppositories on the first stage of labor. International Journal of Advanced Research 2: 128–35.

Noakes D E, Parkinson T J and England G C W. 2019.Veterinary Reproduction and Obstetrics, 10th edn. WB Saunders Company.

Patil A D. 2014. Concurrent use of dinoprostone and valethamate bromide for cervical dilatation in buffaloes. Intas Polivet 15(II): 293–94.

Patil A D and Thorat K. 2013. Comparative efficacy of different cervical dilators in cows and buffaloes. Veterinary Practitioner 14: 58–59.

Phogat J B, Bugalia N S and Gupta S L. 1994. Clinical efficacy of dexamethasone in prolonged gestation and valethamate bromide in dystocia due to insufficient dilation of cervix in buffaloes (Bubalus bubalis). Indian Veternary Journal 7(11): 1085–87.

Pradnya R C and Tank P. 2016. The effect of Hyoscine butyl bromide on the duration and course of labor. Indian Journal of Obstetrics and Gynecology Research 3(2): 148–52. DOI: https://doi.org/10.5958/2394-2754.2016.00041.2

Purohit G N, Barolia Y, Shekher C and Kumar P. 2011. Diagnosis and correction of uterine torsion in cattle and buffaloes. Raksha Tech Rev 2: 11–17.

Purohit G N, Kumar P, Solanki K, Shekher C and Yadav S P. 2012. Perspectives of fetal dystocia in cattle and buffaloes. Veterinary Science Development 2: 31–42. DOI: https://doi.org/10.4081/vsd.2012.3712

Roberts S J. 1986. Diseases and accidents during the gestation period Diagnosis and treatment of the various types of dystocia Injuries and diseases of the puerperal period (Ed.) Roberts S J (2nd edn). Veterinary Obstetrics and Genital Diseases (Theriogenology). Woodstock, pp. 230–359.

Samuels L A, Christie L, Roberts G B, Fletcher H and Frederick J. 2007. The effect of hyoscine butyl bromide on the first stage of labour in term pregnancies. BJOG: An International Journal of Obstetrics and Gynaecology 114(12): 1542–46. DOI: https://doi.org/10.1111/j.1471-0528.2007.01497.x

Shettian N and Shetty S J. 2018. An evaluation of the effect of N – Butylbromide in the form of suppository in augmentation of cervical dilatation during labour, a prospective study at a tertiary care center. Indian Journal of Obstetrics and Gynecology Research 5(3): 357–60. DOI: https://doi.org/10.18231/2394-2754.2018.0082

Singh P and Nanda A S. 1996. Treatment of uterine torsion in buffaloes—Modification of Schaffer’s method. Indian Journal of Animal Reproduction 17: 33–34.

Singla V K, Sharma R D, Gandotra V K and Prabhakar S. 1992. Changes in certain serum biochemical constituents in buffaloes with uterine torsion. Indian Veterinary Journal 69: 805–07.

Sirohiwal D and Dahiya K D M. 2005. Efficacy of hyoscine N Butylbromide (Buscopan) suppositories as a cervical spasmolytic agent in labor. Australian and New Zealand Journal of Obstetrics and Gynaecology 45(2): 128–29. DOI: https://doi.org/10.1111/j.1479-828X.2005.00359.x

Srinivas M, Sreenu M, Lakshmi R N, Subramanyam N K and Devi P V. 2007. Studies on dystocia in graded Murrah buffaloes: A retrospective study. Buffalo Bulletein 26(2): 40–45.

Tehalia M K, Sajjan G R, Korbu J, Venkatesh S and Biradar R. 2008. A comparative study of Hyoscine butylbromide versus Drotaverine hydrochloride in first stage of labor. Journal of Obstetrics and Gynecology of India 58(3): 230–34.

Yadav R, Singh G, Yadav P, Pandey A K, Dutt R, Kumari S and Kumar S. 2021. Uterine torsion in Murrah buffaloes: A study of one year. Ruminant Science 10(1): 225–28. DOI: https://doi.org/10.5455/ijlr.20201031015650