Effects of Xylazine and Dexmedetomidine on clinico-physiological and haemato-biochemical parameters during total intravenous anaesthesia in horses

RAJESH KUMAR  K; J V  VADALIA; R H  BHATT; A R  BHADANIYA; V D  DODIYA; N R  PADALIYA; S H  ZALAVADIYA

doi:10.56093/ijans.v94i9.139304

Authors

RAJESH KUMAR K College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
J V VADALIA College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
R H BHATT College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
A R BHADANIYA College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
V D DODIYA College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
N R PADALIYA College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India
S H ZALAVADIYA College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat 362 001 India

https://doi.org/10.56093/ijans.v94i9.139304

Keywords:

Cardiopulmonary, Dexmedetomidine, Guaifenesin, Haemato-biochemical, Ketamine, Xylazine

Abstract

The present study evaluated the clinico-physiological and haemato-biochemical parameters in 12 native breed horses, irrespective of age and sex, using two different total intravenous anaesthesia (TIVA) triple drip combinations, viz. xylazine, ketamine and guaifenesin (XKG group); and dexmedetomidine, ketamine, and guaifenesin (DKG group). Sedation in both groups was achieved with acepromazine and butorphanol, with xylazine used in the XKG group and dexmedetomidine in the DKG group, followed by ketamine induction and maintenance with the respective TIVA protocols. During different time intervals in the pre, peri and post-operative periods, both groups were assessed for clinico-physiological, haematological and biochemical parameters. The results showed that horses in the DKG group showed balanced and better cardiopulmonary and haemato-biochemical changes when compared to XKG group.

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References

Agivale S M, Khandekar G S, Tripathi S D and Sawandkar P G. 2019. Clinical evaluation of xylazine, ketamine and guaifenesin as total intravenous anaesthesia in equines. Advances in Animal and Veterinary Sciences 7(4): 265–71.

Ambrosio A M, Casaes A G, Ida K K, Souto M T M R, Zechetto L D S, Furtado P V and Fantoni D T. 2012. Differences in blood glucose increase between horses receiving xylazine and detomidine for surgical and non-surgical clinical procedures. Brazilian Journal of Veterinary Research and Animal Science 49(6): 493–99.

Ballard S, Shults T, Kownacki A A, Blake J W and Tobin T. 1982. The pharmacokinetics, pharmacological responses and behavioral effects of acepromazine in the horse. Journal of Veterinary Pharmacology and Therapeutics 5(1): 21–31.

Bettschart-Wolfensberger R and Larenza M P. 2007. Balanced anesthesia in the equine. Clinical Techniques in Equine Practice 6(2): 104–10.

Chaturvedi V. 2005. ‘Comparative study on evaluation of diazepam and midazolam prior to xylazine – ketamine anaesthesia for gelding in equine.’ M. V. Sc Thesis, Maharashtra animal and fishery science University, Nagpur, India.

Daunt D A and Steffey E P. 2002. Alpha-2 adrenergic agonists as analgesics in horses. Veterinary Clinics: Equine Practice 18(1): 39–46.

Day T K and Muir W W. 1993. Alpha 2-adrenergic receptor agonist effects on supraventicular and venticular automacity in dogs with complete atrioventricular block. American Journal of Veterinary Research 54(1): 136–41.

Deepesh K. 2019. ‘Comparative evaluation of total intravenous anaesthesia vis a vis inhalation anaesthesia in equine.’ M.V.Sc Thesis, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

Duke-Novakovski T, Palacios-Jimenez C, Wetzel T, Rymes L and Sanchez-Teran A F. 2015. Cardiopulmonary effects of dexmedetomidine and ketamine infusions with either propofol infusion or isoflurane for anesthesia in horses. Veterinary Anaesthesia and Analgesia 42(1): 39–49.

England G C and Clarke K W. 1996. Alpha 2 adrenoceptor agonists in the horse–a review. Bristish Veterinary Journal 152(6): 641–57.

Fani F A, Mehesare S P, Pawshe D B, Khan K M, and Jadhav D. 2008. Haematological and biochemical changes during epidural xylazine hydrochloride anaesthesia in dogs. Vet World 1(6): 175-7.

Gasthuys F, De Moor A and Parmentier D. 1990. Haemodynamic changes during sedation in ponies. Veterinary Research Communications 14: 309–27.

Giovannitti J A, Jr Thoms S M and Crawford J J. 2015. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesthesia Progress 62(1): 31–39.

Gronwall R and Mia A S. 1972. Fasting hyperbilirubinemia in horses. The American Journal of Digestive Diseases 17(5): 473–76.

Hopster K, Muller C, Hopster-Iversen C, Stahl J, Rohn K and Kastner S. 2014. Effects of dexmedetomidine and xylazine on cardiovascular function during total intravenous anaesthesia with midazolam and ketamine and recovery quality and duration in horses. Veterinary Anaesthesia and Analgesia 41(1): 25–35.

Johnston G M, Eastment J K, Wood J L N and Taylor P M. 2002. The confidential enquiry into perioperative equine fatalities (CEPEF): Mortality results of Phases 1 and 2. Veterinary Anaesthesia and Analgesia 29(4): 159–70.

Kable J W, Murrin L C and Bylund D B. 2000. In vivo gene modification elucidates subtype-specific functions of α2-adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics 293(1): 1–7.

Kalchofner K S, Picek S, Ringer S K, Jackson M, Hassig M and Bettschart-Wolfensberger R. 2009. A study of cardiovascular function under controlled and spontaneous ventilation in isoflurane–medetomidine anaesthetized horses. Veterinary Anaesthesia and Analgesia 36(5): 426–35.

Kaur A. 2018. ‘Evaluation of midazolam and guaifenesin as preanaesthetic agents for general anaesthesia in equine.’ M. V. Sc Thesis, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

Kinjavdekar P, Amarpal G S, Aithal H and Pawde A M. 2000. Physiologic and biochemical effects of subarachnoidally administered xylazine and medetomidine in goats. Small Ruminant Research 38(3): 217–28.

Kullmann A, Sanz M, Fosgate G T, Saulez M N, Page P C and Rioja E. 2014. Effects of xylazine, romifidine, or detomidine on hematology, biochemistry, and splenic thickness in healthy horses. The Canadian Veterinary Journal 55(4): 334.

Lawrence C J, Prinzen F W and De Lange S. 1996. The effect of dexmedetomidine on the balance of myocardial energy requirement and oxygen supply and demand. Anesthesia & Analgesia 82(3): 544–50.

Lemke K A, Tranquilli W J, Thurmon J C, Benson G J and Olson W A. 1993. Hemodynamic Effects of atropine and glycopyrrolate in isoflurane‐xylazine‐anesthetlzed dogs. Veterinary Surgery 22(3): 163–69.

Meagher D M and Tasker J B. 1972. Effects of excitement and tranquilization on the equine hemogram. Modern Veterinary Practice 53(3): 41–43.

Muir W W and Hubbell J A E. 2009. Intravenous anesthetic and analgesic adjuncts to inhalation anesthesia. Equine Anesthesia Monitoring and Emergency Therapy. 2nd edition. Pp 260–276. Saunders, Elsevier.

Muir W W, Lerche P, Robertson J T, Hubbell J A, Beard W, Miller T and Bothwell V. 2000. Comparison of four drug combinations for total intravenous anesthesia of horses undergoing surgical removal of an abdominal testis. Journal of the American Veterinary Medical Association 217(6): 869–73.

Nanda V S, Kumar A, Kanwar M S, Sharma A, Sharma S K and Khurana A. 2014. Continuous maintenance anaesthesia using guaifenesin or diazepam combined with xylazine and ketamine in horses. Indian Journal of Veterinary Surgery 35(2): 89–92.

Sleiman M, Diner D and Simeonora G. 2016. The effects of dexmedetomidine continuous rate infusion (cri) on isoflurane anesthesia in healthy horses. International Journal of Clinical Medicine 7(6): 371–80.

Snedecor G W and Cochran W G. 1980. Statistical methods. 9th edn. Iowa state university Press.

Steffey E P and Howland D E. 1978. Cardiovascular effects of halothane in the horse. American Journal of Veterinary Research 39(4): 611–15.

Thakur B P S, Sharma S K, Sharma A and Kumar A. 2011. Clinical evaluation of xylazine-butorphanol-guaifenesin- ketamine as short-term TIVA in 18 equines. Veterinary Medicine International 6.

Wagner A E, Muir W W 3rd and Hinchcliff K. 1991. Cardiovascular effects of xylazine and detomidine in horses. American Journal of Veterinary Research 52(5): 651–57.

Yamshika K, Satoh M, Umikawa A, Tsuda A, Yajima Y, Tsubakishita S, Seno T, Katoh S, Izumisawa Y and Kotani T. 2000. Combination of continuous intravenous infusion using a mixture of guaifenesin-ketamine- medetomidine and sevoflurane anesthesia in horses. The Journal of Veterinary Medical Science 62(3): 229–35.

Zielmann S, Kazmaier S, Schnull S and Weyland A. 1997. S-(+)- Ketamine and circulation. Der Anaesthesist 46: 43–6.