Evaluation of clinical efficacy of Tiletamine and Zolazepam in combination with Xylazine or Dexmedetomidine in Butorphanol and Atropine premedicated dogs for performing surgical procedures

VIJAYA  MAHANTESH; AMIT KUMAR  SINGLA; ROHIT  KUMAR; ANJALI  SHARMA; SARA  KAUSHAL; KALPANA  THAKUR; YUDHVIR  RANA; DEEPTI  SHARMA; ADARSH  KUMAR; S P  TYAGI

doi:10.56093/ijans.v94i9.140937

Authors

VIJAYA MAHANTESH CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
AMIT KUMAR SINGLA CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
ROHIT KUMAR CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
ANJALI SHARMA CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
SARA KAUSHAL CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
KALPANA THAKUR CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
YUDHVIR RANA CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
DEEPTI SHARMA CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
ADARSH KUMAR CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India
S P TYAGI CSK Himachal Pradesh Agricultural University, Palampur, Himachal Pradesh 176 062 India

https://doi.org/10.56093/ijans.v94i9.140937

Keywords:

Atropine, Butorphanol, Dexmedetomidine, Dogs, Tiletamine-Zolazepam, Xylazine

Abstract

A study was conducted for the clinical evaluation of Tiletamine-zolazepam when used in combination with inj. atropine, inj. butorphanol and either xylazine or dexmedetomidine in 18 client owned dogs presented for ovariohysterectomy. They were divided into two groups: group 1 (n=9) and in group 2 (n=9). The drug regime for groups included inj. butorphanol @ 0.2 mg/kg and inj. atropine @ 0.04 mg/kg followed by inj. xylazine @ 1.0 mg/kg along with tiletamine-zolazepam @ 3.3 mg/kg in group 1 and dexmedetomidine @ 10 µg/kg along with tiletamine-zolazepam @ 4.5 mg/kg in group 2. Animals in both the groups showed smooth induction with adequate muscle relaxation and analgesia. Significant decrease in rectal temperature was noticed in both the groups, which improved during recovery. ECG parameters did not show significant difference from physiological values in majority of animals. Significant increase in heart rate was noticed after induction in both groups, which came back to normal resting values at the end of the study period. Non-invasive blood pressure showed non-significant increase in both the groups initially and later dropped lower than pre-anesthetic value. SpO₂, EtCO₂ and FiCO₂ values remained within the normal range throughout the procedure. Significant decrease in respiration rate was noticed in both groups with no incidence of apnea. Haematological parameters reduced non-significantly at the end of the study period when compared with baseline value in both the groups. Biochemical parameters and electrolytes did not vary significantly throughout the study period except for glucose which showed a significant increase throughout the study in both the groups. Recovery period was longer in group 2. Vocalization with ataxia and head bobbing was noticed in some animals of group 1 and 2 which ended after recovery without any adverse consequences. The protocol used in the study provided safe and adequate anaesthesia for different surgical manipulations that can be performed under 60 min in dogs.

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