Pharmacokinetics and bioavailability of ceftiofur following intravenous and intramuscular administrations in broiler chickens

MOHAMED  ABOUBAKR; MOHAMED  ELBADAWY; AHMED  SOLIMAN; HAZEM  SHAHEEN; MOHAMED  ALKAFAFY; NEHAL  ABDELMAGEED; ASMAA  ELSAYED

doi:10.56093/ijans.v94i2.145678

Authors

MOHAMED ABOUBAKR Pharmacology Department, Faculty of Veterinary Medicine, Benha University, 13736, Qalioubeya, Egypt
MOHAMED ELBADAWY Pharmacology Department, Faculty of Veterinary Medicine, Benha University, 13736, Qalioubeya, Egypt
AHMED SOLIMAN Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt
HAZEM SHAHEEN Pharmacology Department, Faculty of Veterinary Medicine, Damanhur University, 22511 Damanhur, Egypt
MOHAMED ALKAFAFY College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
NEHAL ABDELMAGEED Faculty of Veterinary Medicine, Benha University, 13736, Qalioubeya, Egypt
ASMAA ELSAYED Faculty of Veterinary Medicine, Benha University, 13736, Qalioubeya, Egypt

DOI:

https://doi.org/10.56093/ijans.v94i2.145678

Keywords:

Bioavailability, Ceftiofur sodium, Chickens, HPLC, Pharmacokinetics

Abstract

The study focussed on pharmacokinetics and bioavailability of ceftiofur (CFT) after receiving a single dose (2 mg/kg BW) through either intravenous (IV) or intramuscular (IM) injection. Eight broiler chickens, were used in a crossover design with a washout period of two weeks to analyze the behaviour of CFT. Ceftiofur concentrations in the plasma were determined by HPLC with UV detector. The pharmacokinetics of CFT was analyzed using non- compartmental analysis. Following IV injection, CFT elimination half-life (t1/2β) was 2.43 h, volume of distribution at steady state (Vdss) was 0.63 L/kg, and total body clearance (Cl) was 0.24 L/h/kg. Following a single intramuscular (IM) injection of CFT at the same dose, the drug was quickly absorbed into the bloodstream with an absorption half- life (t1/2ab) of 0.31 h. The maximum concentration of the drug in the plasma (Cmax) was 2.85 μg/mL and reached at a time (Tmax) of 0.57 h after injection and the bioavailability (F) of CFT was 96.25%. The results of the study revealed that CFT was absorbed rapidly and showed high bioavailability when administered by IM route. This suggests that CFT has a promising disposition in chickens, and its use could help determine the best dosage regimens for effective eradication of various infections in chickens.

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