Correlation between diarrhoea associated SNPs and pre-weaning growth rate in Landlly piglets


356 / 212 / 92

Authors

  • MAYANK DARJI ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122 India image/svg+xml
  • NIHAR RANJAN SAHOO ICAR-National Institute of Foot and Mouth Disease, Arugul, Bhubaneswar, Odisha
  • RAJVEER MOURYA ICAR-Indian Veternary Research Institute, Izatnagar, Uttar Pradesh image/svg+xml
  • AMEYA SANTHOSH ICAR- National Dairy Research Institute, Karnal, Haryana image/svg+xml
  • B L SAINI Central Silk Board, Hassan, Karnataka
  • PUSHPENDRA KUMAR ICAR-Indian Veternary Research Institute, Izatnagar, Uttar Prades image/svg+xml
  • G K GAUR Krishi Bhavan, New Delhi
  • SALAUDDIN QURESHI ICAR-Indian Veternary Research Institute, Izatnagar, Uttar Pradesh image/svg+xml
  • AMIT KUMAR ICAR-Indian Veternary Research Institute, Izatnagar, Uttar Pradesh image/svg+xml
  • ARVIND SONWANE ICAR- Central Institute of fisheries education, Mumbai, Maharashtra. image/svg+xml

https://doi.org/10.56093/ijans.v95i1.148482

Keywords:

ETECF4, ETECF18, Growth rate, Landlly piglets, Pre weaning diarrhoea

Abstract

The present study was aimed to investigate the relationship between diarrhoea-associated polymorphisms and pre-weaning growth rates in an organized Landlly herd. A total of 250 piglets were genotyped for 10 shortlisted SNPs and assessed for pre-weaning growth rates, with body weights recorded from birth to the 6th week of age. Seven out of the 10 SNPs were found to be polymorphic in the target population, with the MUC 4-g.8227 G>C locus significantly affecting growth rates of the 2nd to 4th week piglets whereas, the MUC 20-g.191 affected growth rates at the 4th week of age. These findings suggest that the g.8227C>G and g.191C>T SNP polymorphisms are associated with both growth performance and diarrhoea in piglets, recommending that a balanced approach should be maintained between health status and growth performance in piglet selection programs.

Downloads

Download data is not yet available.

References

Ajay A, Chauhan A, Vaishnav S, Rani C, Kumar B, De U K, Verma M R, Singh M and Gaur G K. 2023. Impact of body condition on sow and litter performance, postpartum physiological, hematological, and biochemical parameters in Landlly crossbred pigs. Tropical Animal Health and Production 55(6): 393.

Fairbrother J M, Nadeau É and Gyles C L. 2005. Escherichia coli in postweaning diarrhoea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Animal Health Research Reviews 6: 17-39.

Fontanesi L, Bertolini F, Dall’Olio S, Buttazzoni L, Gallo M and Russo V. 2012. Analysis of association between the MUC4 g. 8227C> G polymorphism and production traits in Italian heavy pigs using a selective genotyping approach. Animal Biotechnology 23: 147-55.

Fratto A, Torricelli M, Sebastiani C, Ciullo M, Felici A and Biagetti M. 2024. Survey on resistance occurrence for F4+ and F18+ enterotoxigenic Escherichia coli (ETEC) among pigs reared in Central Italy regions. Veterinary Research Communications 48(2): 1279-84.

Jacobsen M, Kracht S S, Esteso G, Cirera S, Edfors I, Archibald A L, Bendixen C, Andersson L, Fredholm M and Jørgensen C B. 2010. Refined candidate region specified by haplotype sharing for Escherichia coli F4ab/F4ac susceptibility alleles in pigs. Animal Genetics 41: 21-25.

Ji H, Ren J, Yan X, Huang X, Zhang B, Zhang Z and Huang L. 2011. The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Molecular Biology Reports 38: 1593-601.

Meijerink E, Fries R, Vögeli P, Masabanda J, Wigger G, Stricker C, Neuenschwander S, Bertschinger H U and Stranzinger G. 1997. Two α (1, 2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Mammalian Genome 8: 736-41.

Rawat C, Sahoo N R, Wagh S S, Kumar P, Kumar S, Sonwane A, Qureshi S, Kumar A and Panigrahi M. 2019. Association of ACK1, TFRC polymorphism with diarrhoeagenic E. coli adhesion patterns and their jejunal expression profile in Indian Ghurrah pigs. Biotech 9: 1-10.

Ren J, Tang H, Yan X, Huang X, Zhang B, Ji H, Yang B, Milan D and Huang L. 2009. A pig–human comparative RH map comprising 20 genes on pig chromosome 13q41 that harbours the ETEC F4ac receptor locus. Journal of Animal Breeding and Genetics 126: 30-36.

Sambrook J and Russell D W. 2001. Molecular Cloning, a Laboratory Manual, 3rd edition. Cold Spring Harbor Laboratory Press, NY, USA.

Shi Q S. 2003. The review of the receptors of ETEC F4. Pigs and Poultry 23: 33-35.

Sinha R, Sahoo N R, Kumar P, Qureshi S, Kumar A, Ravikumar G V, Bhushan B. 2018(a). Comparative jejunal expression of MUC 13 in Indian native pigs differentially adhesive to diarrhoeagenic E. coli. Journal of Applied Animal Research 46: 107-111.

Sinha R, Sahoo N R, Shrivastava K, Kumar P, Qureshi S, Kumar A, Ravi Kumar G V and Bhushan B. 2018(b). Effect of Mucin13 gene polymorphism on diarrhoeagenic E. coli adhesion pattern and its expression analysis in native Indian pigs. Archives Animal Breeding 61: 321-28.

Sinha R, Sahoo N R, Shrivastava K, Kumar P, Qureshi S, De U K, Kumar A, Kumar G V and Bhushan B. 2019. Resistance to ETEC F4/F18–mediated piglet diarrhoea: opening the gene black box. Tropical Animal Health and Production 51:1307-20.

Sinha R, Sahoo N R, Shrivastava K, Vineeth M R, Kumar P, Qureshi S, Kumar A and Bhushan B. 2021. Effect of season, age and sex on E. coli adhesion patterns in Indigenous Ghurrah pigs-a comparative analysis of phenotypic classifications. Biological Rhythm Research 52: 1217-28.

Van Den Broeck W, Cox E, Oudega B and Goddeeris B M. 2000. The F4 fimbrial antigen of Escherichia coli and its receptors. Veterinary Microbiology 71: 223-44.

Wagh S S. 2016. Genetic polymorphism in porcine mucin 4 and mucin 20 genes and their association with E. coli adhesion pattern. Master’s thesis. IVRI, Izatnagar, U.P, India.

Wang S J, Liu W J, Yang L G, Sargent C A, Liu H B, Wang C, Liu X D, Zhao S H, Affara N A, Liang A X and Zhang S J. 2012. Effects of FUT1 gene mutation on resistance to infectious disease. Molecular Biology Reports 39: 2805–10.

Submitted

2024-02-14

Published

2025-02-04

Issue

Section

Short-Communication

How to Cite

DARJI, M. ., SAHOO, N. R. ., MOURYA, R. ., SANTHOSH, A. ., SAINI, B. L. ., KUMAR, P. ., GAUR, G. K. ., QURESHI, S. ., KUMAR, A. ., & SONWANE, A. . (2025). Correlation between diarrhoea associated SNPs and pre-weaning growth rate in Landlly piglets. The Indian Journal of Animal Sciences, 95(1), 67–70. https://doi.org/10.56093/ijans.v95i1.148482
Citation