Effect of magnesium sulphate on duration and dose requirement of thiopental sodium anesthesia in dogs undergoing experimental enterotomy

IBRAHIM HELAL; MOHAMED EL DAHRAWY

doi:10.56093/ijans.v82i10.24289

Authors

IBRAHIM HELAL Suez Canal University, Ismilia 41522 Egypt
MOHAMED EL DAHRAWY Suez Canal University, Ismilia 41522 Egypt

https://doi.org/10.56093/ijans.v82i10.24289

Keywords:

Anesthesia, Dogs, Magnesium sulphate, Thiopental sodium

Abstract

Adult mongrel dogs (15) of either sex, 1.8±0.7-year-old and weighing 15.56±0.06 kg (mean±SE) were used in the study to evaluate the effect of pre-and intra-operative administration of magnesium sulphate (MgSO₄) on the duration and dose of thiopental sodium antesthesia undergoing enterotomy. All dogs were premedicated with intramuscular injection of chloropromazine hydrochloride 15 min prior to the injection of 2.5% thiopental sodium in group 1. In group 2, i/v administration of chloropromazine hydrochloride followed by a bolus of 50 mg/kg MgSO₄ (10%) were used before injection of general anaesthesia. In group 3, the dogs received the same anesthetic protocol as in group 2 in addition to i/v infusion of MgSO₄ (10%) @10 mg/kg/hr. Enterotomy model was created in all dogs and the mean operation time was 34 min. The results revealed that mean duration of anesthesia was significantly longer in groups 2 and 3 (43.40 and 57.60 min, respectively) as compared to group 1 (38.60 min). The mean total thiopental sodium dose in group 1 (32.10 mg/kg) was significantly greater than those of groups 2 and 3 (26.70 and 20.20 mg/kg respectively). It could be concluded that preoperative and intraoperative administration of MgSO₄ prolong duration of anesthesia, decrease the total dose of thiopental sodium, and facilitate smooth recovery.

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Author Biographies

IBRAHIM HELAL, Suez Canal University, Ismilia 41522 Egypt
MOHAMED EL DAHRAWY, Suez Canal University, Ismilia 41522 Egypt

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