Evaluation of anaesthetic stress following administration of dexmedetomidine and its combinations with midazolam, fentanyl and ketamine in dogs

RAJA AIJAZ AHMAD; AMARPAL AMARPAL; P KINJAVDEKAR; H P AITHAL; A M PAWDE; DINESH KUMAR

doi:10.56093/ijans.v82i12.25662

Authors

RAJA AIJAZ AHMAD Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
AMARPAL AMARPAL Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
P KINJAVDEKAR Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
H P AITHAL Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
A M PAWDE Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
DINESH KUMAR Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India

https://doi.org/10.56093/ijans.v82i12.25662

Keywords:

Dexmedetomidine, Dogs, Fentanyl, Midazolam, Stress indicators

Abstract

The study was conducted on 16 apparently healthy adult dogs of either sex, randomly divided into 4 groups, each containing 4 animals. Animals of group A received dexmedetomidine (20 µg/kg) alone. Midazolam (0.2 mg/kg), fentanyl (4 µg/kg) + midazolam (0.2 mg/kg) and ketamine (10 mg/kg) + fentanyl (4 µg/kg) + midazolam (0.2 mg/kg) were administered along with dexmedetomidine (20 µg/kg) in the animals of groups B, C and D, respectively. All the drugs were given simultaneously by intramuscular route. Differential leucocytic count, plasma glucose, insulin and cortisol were measured at baseline (0 min) and at 30, 60 and 120 min after the drug administration. Neutrophilia was observed only for a very short period. Plasma insulin levels significantly decreased whereas a significant increase in the plasma glucose towards the end of the study period was observed except in group C in which it decreased. Cortisol levels were nonsignificantly lower than the base values throughout the study in all the groups. It could be concluded that dexmedetomidine and its combinations with midazolam, fentanyl and ketamine do not threaten homeostasis and can obtund the stress response associated with handling and anaesthetic procedures in dogs.

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Author Biographies

RAJA AIJAZ AHMAD, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
AMARPAL AMARPAL, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
P KINJAVDEKAR, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
H P AITHAL, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
A M PAWDE, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
DINESH KUMAR, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India

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