Gross, histopathological and electronmicroscopic studies of canine mammary gland tumour treated with NS1 gene of canine parvo virus

A K VERMA; N S JADON; PRIYANKA PANDEY; A K TIWARI

doi:10.56093/ijans.v84i4.39833

Authors

A K VERMA Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand 263 145 India
N S JADON Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand 263 145 India
PRIYANKA PANDEY Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand 263 145 India
A K TIWARI Indian Veterinary Research Institute, Izatnagar

https://doi.org/10.56093/ijans.v84i4.39833

Keywords:

Female dog, MGT, NS1 gene

Abstract

Female dogs (10) affected with mammary gland tumour (MGT) included in this study were treated with NS1 gene of canine parvo virus @ 200 µg intratumoural at weekly interval up to 4 week interval. Physical and clinical symptoms were noticed before and after treatment i.e at 0, first, second, third and fourth week of the treatment. The efficacy of the treatment was assessed on the basis of regression of tumour mass of mammary gland tumours, histopathological and electronmicroscopic (SEM and TEM) studies of biopsy samples of mammary tumour tissues. The parameters observed in this study revealed that the NS1 gene have apoptotic activity in regression of mammary gland tumours.

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