Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration


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Authors

  • ABUL HASAN MD ABIDUR RAHAMAN West Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 India
  • MADHUCHHAANDA KHAN West Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 India
  • TAPAN KUMAR MANDAL West Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 India

https://doi.org/10.56093/ijans.v84i8.43212

Keywords:

Carbontetrachloride, Disposition kinetics, Goats, Hepatopathy, Sparfloxacin

Abstract

Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of group 1 and disposition kinetics and protein binding studies were conducted in plasma. Liver of each goat of group 2 and 3 were damaged by subcutaneous administration of carbontetrachloride and considered as experiment no.2. Sparfloxacin was administered intravenously to group 2 for disposition kinetics and protein binding study. In experiment no.3 rejuvenation of liver of animals of group 2 were done by oral administration of a commercial medicine for consecutive 21 days period. Animals of group 3 were considered as untreated control for the commercial medicine. The results of icterus index, bromosulphophthalein clearance, serum transaminase activity suggested that carbontetrachloride at the recommended dose level produced hepatopathy of goats. The commercial medicine treatment brought all the altered values of plasma kinetic parameters to base level and regenerated the damaged tissue of liver. Disposition kinetic study of sparfloxacin showed that carbontetrachloride –induced damage liver retained Sparfloxacin for same period with almost equi concentration.

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2014-08-12

Published

2014-08-14

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How to Cite

RAHAMAN, A. H. M. . A., KHAN, M., & MANDAL, T. K. (2014). Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration. The Indian Journal of Animal Sciences, 84(8), 833–838. https://doi.org/10.56093/ijans.v84i8.43212
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