Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration
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Keywords:
Carbontetrachloride, Disposition kinetics, Goats, Hepatopathy, SparfloxacinAbstract
Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of group 1 and disposition kinetics and protein binding studies were conducted in plasma. Liver of each goat of group 2 and 3 were damaged by subcutaneous administration of carbontetrachloride and considered as experiment no.2. Sparfloxacin was administered intravenously to group 2 for disposition kinetics and protein binding study. In experiment no.3 rejuvenation of liver of animals of group 2 were done by oral administration of a commercial medicine for consecutive 21 days period. Animals of group 3 were considered as untreated control for the commercial medicine. The results of icterus index, bromosulphophthalein clearance, serum transaminase activity suggested that carbontetrachloride at the recommended dose level produced hepatopathy of goats. The commercial medicine treatment brought all the altered values of plasma kinetic parameters to base level and regenerated the damaged tissue of liver. Disposition kinetic study of sparfloxacin showed that carbontetrachloride –induced damage liver retained Sparfloxacin for same period with almost equi concentration.
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References
Arsul V A, Wagh S R and Mayee R V. 2011. Hepatoprotective activity of Livergen, a polyherbal formulation against Carbontetrachloride induced hepatotoxicity in rats. International Journal of Pharmacy and Pharmaceutical Sciences 3(3): 228–31.
Chaudhari B P, Chaware V J, Joshi Y R and Biyani K R. 2009. Hepatoprotective activity of Hydroalcoholic extract of Momordica charantia Linn. leaves against carbontetrachloride induced hepatopathy in rats. International Journal of Chem Tech Research 1 (2): 355–58.
Cornelius C E. 1989. Liver function. Clincal Bio-chemistry of Domestic Animals. 4th edn, pp.365–419. (Ed.) Kaneko J J. Academic Press, San Deiego.
Frazier D L, Thompson L, Trettien A and Evans E I. 2000. Comparison of fluoroquinolone pharmacokinetic parameters after treatment with marbofloxacin, enrofloxacin, and difloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics 23: 293–302. DOI: https://doi.org/10.1111/j.1365-2885.2000.00285.x
Jamir C, Debnath S C, Das S K, Chakraborty A K and Mandal T K. 2005.Effect of Carbontetrachloride induced hepatopathy on the disposition kinetics of closantel in goats. Iranian journal of Pharmacology and Therapeutics 4: 76–79.
Kumar P V, Sivaraj A, Elumalai E K and Kumar B S. 2009.Carbontetrachloride induced hepatopathy in rats – protective role of aqueous leaf extracts of Coccinia grandis. International Journal of Pharm Tech Research 1 (4): 1612–15.
Mandal T K, Chakraborty A K, and Bhattacharya, A. 1995. Disposition kinetics of cypermethrin and Fenvalerate in black Bengal lactating goats .Paste science 45: 215–19. DOI: https://doi.org/10.1002/ps.2780450304
Oser B L. 1965. Hawk’s Physiological Chemistry .14th Ed. Tata Mc graw Publishing Ltd, New Delhi.
Pillowed M. Pharmacokinetics, Plasma Protein Binding and Dosage of Oxytetracycline in Cattle and Horses.1973. Research in Veterinary Science 15: 224–30. DOI: https://doi.org/10.1016/S0034-5288(18)33833-5
Pandey G P, Srivastava P N, Shrivastava A N, Sharma I J and Srivastava A B. 1983. Studies on histopathological changes in carbontetrachloride induced hepatotoxicity and the protective effect of Livol® in dogs. Indian Veterinary Journal 60 (12): 978–80.
Seth S D. 2000. Textbook of Pharmacology. 2nd edn, pp. 542–43.
Sisodia C S, Miller G E and Stowf C M. 1965. Protein binding of sulphonamides and quinine in bovine milk and plasma. Indian Veterinary Journal 42: 7–16.
Wooton I D P. 1974. Estimation of protein by Bi-uret method. Microanalysis in Medical Biochemistry. 5th edn, pp. 156–58. Churchill Livingstone, Edinburgh and London.
Yatizidis H. 1960. Measurement of transaminase in serum. Nature (London) 18: 79–80. DOI: https://doi.org/10.1038/186079a0
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