Ketamine and its combination with pentazocine and meperidine for epidural anaesthesia in dogs

R P RAM; L L DASS; A K SHARMA

doi:10.56093/ijans.v84i9.43512

Authors

R P RAM Birsa Agricultural University, Kanke, Ranchi, Jharkhand 834 006 India
L L DASS Birsa Agricultural University, Kanke, Ranchi, Jharkhand 834 006 India
A K SHARMA Birsa Agricultural University, Kanke, Ranchi, Jharkhand 834 006 India

https://doi.org/10.56093/ijans.v84i9.43512

Keywords:

Clinico- anaesthetic changes, Dog, Ketamine, Meperidine, Pentazocine

Abstract

Clinically healthy dogs (15) of either sex aged about 1 year were randomly grouped into 3 with 5 dogs each to study the effect of epidural administration of ketamine alone and in combination with pentazocine and meperidine on clinic – anaesthetic profile in dogs. Ketamine hydrochloride @3 mg/kg b.wt and ketamine @3mg/kg b.wt in combination with pentazocine lactate @ 0.3 mg/kg b.wt and ketamine @ 3mg/kg b.wt in combination with meperidine @ 1mg/kg b.wt were administered epidurally in animals of group 1, 2 and 3, respectively. Marked alteration in rectal temperature, heart rate and respiration rate were recorded at initial intervals of observations in all the groups, however, these values returned towards normalcy by the end of 120 min of observation. Quicker onset of analgesia was recorded in group 2 (3.68±0.22 min) followed by group 3 (3.88±0.17 min) and group 1 (4.08±0.33 min). The duration of analgesia, standing time and recovery time were significantly longer in group 2 and 3 as compared to group 1. None of the groups showed significant variation in duration of recumbency. The treated animals manifested minimum, transient and occasional untoward reactions. It is concluded that pentazocine and meperidine can be given epidurally in combination with ketamine for effective analgesia in dogs.

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References

Adetunji A, Ajadi R A and Aladesawe T A. 2001. A comparison of epidural anaesthesia with lignocaine bupivacaine and lignocaine / bupivacaine Mixture in dogs. Israel Journal of Veterinary Medicine 56 (3): 1–6.

Aithal H P, Amarpal, Kinjavedekar P and Suryawanshi S. 1999. Analgesic and cardiopulmonary effects of pethidine and medetomidine after epidural administration in dogs. Indian Journal of Animal Sciences 69 (10): 790–794.

Aithal H P, Amarpal and Singh G R.1998. Epidural use of ketamine for hindquarter analgesia in dogs. Indian Journal of Animal Sciences 68(6): 554.

Amarpal, Aithal H P, Kinj.avdekar P and Singh G R 1998. Effects of epidural ketamine and pethidine in dogs. Indian Journal of Veterinary Surgery 19 (1): 62.

Amarpal, Aithal H P, Kinjavdekar P and Singh G. R.2003. Interaction betweenepidurally administered ketamine and pethidine in dogs. Journal of Veterinary Medicine- A 50 (5), 254 – 58. DOI: https://doi.org/10.1046/j.1439-0442.2003.00497.x

Atalan G, Uzun M, Demirkan I, Yildiz S and Cenesiz M. 2002. Effect of Medetomidine-Butorphanol-Ketamine Anaesthesia and Atipamezole on Heart and Respiratory Rate and Cloacal Temperature of Domestic Pigeons. Journal of Veterinary Medicine- A 49 (6): 281–85. DOI: https://doi.org/10.1046/j.1439-0442.2002.00451.x

Chaney M A.1995. Side effects of intrathecal and epidural opioids. Canadian Journal of Anaesthesia 42: 891–903. DOI: https://doi.org/10.1007/BF03011037

Chapman V and Dickenson A H. 1992. The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. European Journal of Pharmacology 219: 427–33. DOI: https://doi.org/10.1016/0014-2999(92)90484-L

Collett B J. 2001.Chronic opioid therapy for non-cancer pain. British Journal of Anaesthesia 87 (1) : 133–43. DOI: https://doi.org/10.1093/bja/87.1.133

Cousins M J and Mather L E. 1984. Intrathecal and epidural administration of opioids. Anaesthesiology 61: 273–310. DOI: https://doi.org/10.1097/00000542-198409000-00008

Crisp T, Perrotti J M and Smith D L.1991. The local monoaminergic dependency of spinal ketamine. European Journal of Pharmacology 194: 167–72. DOI: https://doi.org/10.1016/0014-2999(91)90101-U

De Rossi R, Sampaio B F B, Varela J V and Junqueira A L. 2004.Perineal analgesia and hemodynamic effects of the epidural administration of meperidine or hyperbaric bupivacaine in conscious horse. Canadian Veterinary Journal 45(1): 42–47.

Dickenson A H. 1994. NMDA receptor antagonists as analgesic. Progress in Pain Research and Management. pp.173–87. (Eds) Fields H L and Liebeskind J C. IASP Press, Seattle.

Duque J C, valadao C A A, Farias A, DeAlmeida R M and Oleskovicz N. 2004.Pre-emptive epidural ketamine or S(+)- ketamine in post-incisional pain in dogs: A comparative study. Veterinary Surgery 33(4): 361–67. DOI: https://doi.org/10.1111/j.1532-950X.2004.04052.x

Forman LJ.1999. NMDA receptor antagonism produces antinoception which is partially mediated by brain opiois and dopamine. Life Science 64: 1877–87. DOI: https://doi.org/10.1016/S0024-3205(99)00134-4

Hall L W and Clarke K W. 1991. Veterinary Anaesthesia. 9th edn, pp: 324–327.Bailliere Tindall, London.

Hellyer P W, Freeman L C and Hubbell J A.1991. Induction of anaesthesia with diazepam –ketamine and midazolam – ketamine in greyhounds. Veterinary Surgery 20(2): 143–7. DOI: https://doi.org/10.1111/j.1532-950X.1991.tb00324.x

Hustveit O, Maurset A and Oye I.1995. Interaction of the chiral forms of ketamine with opioid, hencyclidine, sigma and muscarinic receptors. Pharmacology and Toxicology 77: 355– 359. DOI: https://doi.org/10.1111/j.1600-0773.1995.tb01041.x

Idvall J, Ahlgren I, Aronsen K R and Stenber G P. 1979. Ketamine infusions: pharmacokinetics and clinical effects. British Journal of Anaesthesiology 51: 1167–73. DOI: https://doi.org/10.1093/bja/51.12.1167

Jones R S. 2001.Epidural analgesia in the dog and cat. Veterinary Journal 161: 123–131. DOI: https://doi.org/10.1053/tvjl.2000.0528

Kumar A, Jadon N S and Singh B. 1988. Neuroleptanalgesia with meperidine and promazine in dogs. Indian Veterinary Journal 65 (2): 126–32.

Pascoe P J. 2000. Opioid analgesia. Veterinary Clinics of North America Small Animal Practice 30 (4): 757–72. DOI: https://doi.org/10.1016/S0195-5616(08)70005-6

Rafael D R, Breno F B, Juliana V V and Alexandre L J. 2004. Perineal analgesia and haemodynamic effects of the epidural administration of meperidine or hyperbaric bupivacaine in conscious horses. Canadian Veterinary Journal 45 (1): 42–47.

Reich D L and Silvay G. 1989. Ketamine: an update on the first 25 years of clinical experience. Canadian Journal of Anaesthesiology 36: 186–97. DOI: https://doi.org/10.1007/BF03011442

Roman T S and William W M. 2001 Analgesic, hemodynamic, and respiratory effects induced by caudal epidural administration of meperidine hydrochloride in mares. American Journal of Veterinary Research 62 (7): 1001–07. DOI: https://doi.org/10.2460/ajvr.2001.62.1001

Sethi M, Sethi N, Jain P and Sood J.2011. Role of epidural ketamine for post – operative analgesia after upper abdominal surgery. Indian Journal of Anaesthesiology 55(2): 141–45. DOI: https://doi.org/10.4103/0019-5049.79894

Sharma Y K, Pandey S S, Pandey S K and Sharma R K. 2005.Clinico- physiological effects of epidural buprenorphine in combinations with bupivacaine, xylazine or ketamine in dogs. Indian Journal of Veterinary Surgery 26 (1): 43–44.

Snedecor G W and Cochran W G. 1994. Statistical Methods. 8th edn. Iowa State University Press, Ames, Iowa.

Thurman J C, Tranquilli W J and Bensen G J. 1996. Lumb and Jone’s Veterinary Anaesthesia: 3rd edn, pp 244.Williums and Wilkins, Lea and Febiger.

White P F, Way W L and Trevor A J. 1982. Ketamine – its pharmacology and therapeutic uses. Anaesthesiology 56 : 119. Wong C S, Shen T T, Liaw W J, Cheng C H and Ho S T.1996. Epidural coadministration of ketamine, morphine and bupivacaine attenuates post – hepatic neuralgia – A case report. Acta Anaesthesiology Sin 34: 151–55. DOI: https://doi.org/10.1097/00000542-198202000-00007

Yaksh T L. 1993. The spinal actions of opoids. Handbook of Experimental Pharmacology 104: 53–89. DOI: https://doi.org/10.1007/978-3-642-77540-6_3

Yaksh T L. 1996. Epidural ketamine: a useful, mechanistically novel adjuvant for epidural morphine? Regional Anesthesia 21: 508–13.