Disposition kinetics of ceftizoxime in acute mastitis in Murrah buffaloes


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Authors

  • RAKESH KUMAR West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal 700 037 India
  • T K SAR West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal 700 037 India
  • P H PATRA College of Veterinary Sciences and Animal Husbandry, Agartala, Tripura
  • I SAMANTA College of Veterinary Sciences and Animal Husbandry, Agartala, Tripura
  • AKHILESH MISHRA West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal 700 037 India
  • T K MANDAL West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal 700 037 India

https://doi.org/10.56093/ijans.v86i2.55774

Keywords:

Buffalo, Ceftizoxime, Mastitis, Milk level, Pharmacokinetics

Abstract

Acute mastitis was induced by inoculation of Staphylococcus aureus in 6 buffaloes. Ceftizoxime was administrated intravenously @25 mg/kg to evaluate pharmacokinetics of ceftizoxime in mastitic buffaloes. The maximum mean plasma concentration of ceftizoxime was recorded at 0.08 h in healthy buffaloes which was followed by decreased plasma concentration of 23.53 ± 0.84 µg/ml at 1 h and persisted up to 24 h. Mean values of t½ß were 5.86 ± 0.18 and 8.42 ± 0.58 h in healthy and induced mastitic buffaloes, respectively. Mean Vdarea value of 1.10 ± 0.06 L/kg in healthy buffaloes was increased significantly. The maximum mean milk concentration of ceftizoxime at 2 h (73.34 ± 4.35 µg/ml) in lactating buffaloes decreased gradually till 12 h (31.31 ± 5.66 µg/ml) and persisted up to 96 h (1.57 ± 0.20 µg/ml). So, ceftizoxime can be used for treatment of staphylococcal mastitis in buffaloes.

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References

Baggot J D. 1977. Principles of Drug Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology, W. B. Saunders Co., Philadelphia, London.

Karmakar U, Datta B K, Patra P H, Prashant M, Suman S, Sar T K, Chakraborty A K and Mandal T K. 2011. Dispostion kinetics of ceftizoxime in healthy and mastitic goats after intravenous administration. Pharmacology online 3: 935–46.

National Mastitis Council. 1999. Laboratory Handbook on Bovine Mastitis. Inc., Madison, Wisconsin, USA. 44p.

Sar T K, Mandal T K, Samanta I, Rahaman A and Chanraborty A K. 2010. Determination of ceftriaxone in plasma and ceftizoxime in milk of mastitic cows following single dose intravenous administration. Indian Journal of Animal Sciences 80: 1182–84.

Sar T K, Mandal T K, Das S K, Chakraborty A K and Bhattacharyya A. 2006. Pharmacokinetics ceftriaxone in healthy and mastitic goats with special reference to its interaction with polyherbal drug Fibrosin®. International Journal of Applied Research in Veterinary Medicine 4: 142– 54.

Sar T K, Patra P H, Dash J R and Mandal T K. 2011. Pharmacokinetic interaction of intramammary ceftriaxone and oral polyherbal drug (Fibrosin ®) in goats. Drug Metabol Drug Interact 26: 191–96. DOI: https://doi.org/10.1515/DMDI.2011.019

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Submitted

2016-02-09

Published

2016-02-11

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Articles

How to Cite

KUMAR, R., SAR, T. K., PATRA, P. H., SAMANTA, I., MISHRA, A., & MANDAL, T. K. (2016). Disposition kinetics of ceftizoxime in acute mastitis in Murrah buffaloes. The Indian Journal of Animal Sciences, 86(2), 140–142. https://doi.org/10.56093/ijans.v86i2.55774
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