Genetic variation of RFXANK gene in Stavropol sheep breed
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Keywords:
RFXANK gene, Sheep, SNP, Stavropol breed.Abstract
Using of NimbleGen sequencing technology for detection of polymorphisms RFXANK gene in Stavropolsheep breed, we found 20 SNPs. That is, two SNP in exons - c.63C>A (non synonymous) in exon II and c.498G>A in exon VI (synonymous). Others SNP is in introns: c.-343T>C, c.- 111T>G, c.187+328G>A, c.338-94G>A, c.632–124G>A, c.713-82G>A, c.187+62G>A, c.188-588G>C, c.188- 127C>T, c.565-44A>G, c.712+309C>T, c.712+354C>T, c.712+309C>T, c.187+394C>T, c.187+469A>G, c.187+71G>C, c.188-670A>G, c.713-107G>T. Some of them are presented together.
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Aboneev V V, Quito Y D, Serdyukov I G and Sannikov M Y. 2011. Stavropol breed is 60 years old! Scientific and industrial magazine “Sheep, goats, wool business» 4: 1–3.
Ensembl project. 2014. RFXANK ENSOARG00000009235. http://www.ensembl.org/Ovis_aries/Gene/Summary?g=ENSOARG00000009235;r=5:3825886–3830327;t=ENSOART00000010054. Accessed 15 February 2015
Lin J H, Makris A, McMahon C, Bear S E, Patriotis C, Prasad V R, Brent R, Golemis E A and Tsichlis P N. 1999. The ankyrin repeat containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. Journal of Biological Chemistry 274: 14706–15. DOI: https://doi.org/10.1074/jbc.274.21.14706
Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez J C, Hochstrasser D F, Mach B and Reith W. 1998. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nature Genetics 20: 273–77. DOI: https://doi.org/10.1038/3081
Nagarajan U M, Peijnenburg A, Gobin S J, Boss J M and van den Elsen P J. 2000. Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells. Journal of Immunological Methods 164: 3666–74. DOI: https://doi.org/10.4049/jimmunol.164.7.3666
NCBI. 2014. Ovisaries SNP Database, Shotgun Sequence, Nekrep N, Geyer M, Jabrane-Ferrat N and Peterlin B M. 2001. Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome. Molecular and Cellular Biology 21: 5566–76. DOI: https://doi.org/10.1128/MCB.21.16.5566-5576.2001
NimbleGenSeqCap EZ Library LRUser’sGuideVersion 2.0 http://www.nimblegen.com/products/lit/seqcap/ez/index.html Accessed 15 February 2015.
Rader K, Boyer A D, Farquhar M G and Arden K C. 2000. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12–.q13 by radiation hybrid mapping and somatic cell hybrid PCR. Cytogenetics and cell genetics 89: 164–65. DOI: https://doi.org/10.1159/000015604
Roche NimbleGen http://www.nimblegen.com. Accessed 15 February 2015. DOI: https://doi.org/10.1101/pdb.prot084855
Standard protocol GS Junior system manual http://454.com/my454/documentation/gs-junior-system/pdf-manuals.asp Accessed 15 February 2015.
Zhang L1, Liu J, Zhao F, Ren H, Xu L, Lu J, Zhang S, Zhang X, Wei C, Lu G, Zheng Y and Du L.. 2013. Genome-wide association studies for growth and meat production traits in sheep. PLoS ONE 8 (6) e66569: 1–12. DOI: https://doi.org/10.1371/journal.pone.0066569
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