Alteration of metabolic biomarkers and oxidative stress indices in pashmina (Changthangi) goats under climate change

MOHD IQBAL YATOO; MAHESHWAR SINGH KANWAR; SARFARAZ AHMAD WANI; DINESH KUMAR; UMESH DIMRI

doi:10.56093/ijans.v86i4.57725

Authors

MOHD IQBAL YATOO Indian Veterinary Research Institute, Izatnagar
MAHESHWAR SINGH KANWAR Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir 194 101 India
SARFARAZ AHMAD WANI Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir 194 101 India
DINESH KUMAR Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir 194 101 India
UMESH DIMRI Indian Veterinary Research Institute, Izatnagar

https://doi.org/10.56093/ijans.v86i4.57725

Keywords:

Biomarker, Metabolism, Nutrient deficiency, Oxidative stress, Pashmina goats.

Abstract

The main aim of this study was to evaluate climate change induced variation of metabolic biomarkers and oxidative stress indices in different age groups of pashmina goats. Adult animals in comparison to young and old animals had significantly higher levels of glucose, glycated haemoglobin (GHb), fructosamine and total protein during summer and significantly higher levels of glucose, fructosamine and haemoglobin (Hb) during winter. Significantly reduced levels of these biochemicals were noted in winter than summer in all age groups except for glucose in young and old, GHb in young and Hb in adult animals. Urea and acetoacetate levels were significantly higher in young animals than adults during winter. Higher betahydroxybutyrate and lower propionate levels were noted during winter than summer in all age groups. Significantly higher levels of insulin, T₃, T₄ and lower levels of TSH and cortisol in adult animals were noted in both seasons. Significant rise of insulin in adult, T₃ and T₄ in young and old, cortisol in young and TSH in all animals occurred during winter. Level of GSH in summer, CAT and SOD in winter were significantly higher in adult animals whereas, that of LPO were in young animals. Decrease in levels of antioxidants and increase of oxidants during winter was significant in all age groups. Hence, young and old age groups of pashmina goats are more vulnerable to metabolic alterations under climatic stress than the adult group.

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References

Alayash A I, El-Hassan A M, Omer R and Bonaventura J. 1988. Glycosylated haemoglobin: an indicator of long-term blood glucose in domestic sheep and goats. Comparative Biochemistry Physiology A: Comparative Physiology 90: 229– 31. DOI: https://doi.org/10.1016/0300-9629(88)91108-5

Bergmeyer H U. 1983. UV method of catalase assay. Methods of Ezymatic Analysis. Volume 3. Pp 273. Weinheim Deer Field Beach, Florida, USA.

Bhattacharya T K, Misra S S, Sheikh F D, Kumar P and Sharma A. 2004. Changthangi goats: A rich source of Pashmina production in Ladakh. AGRI 35: 75–85. DOI: https://doi.org/10.1017/S1014233900001826

Bórnez R, Linares M B and Vergara H. 2009. Haematological, hormonal and biochemical blood parameters in lamb: Effect of age and blood sampling time. Livestock Science 121: 200– 06. DOI: https://doi.org/10.1016/j.livsci.2008.06.009

Brashear A and Cook G A. 1983. A spectrophotometric, enzymatic assay for D-3-hydroxybutyrate that is not dependent on hydrazine. Analytical Biochemistry 131: 478–82. DOI: https://doi.org/10.1016/0003-2697(83)90201-4

Cantley C E, Ford C M and Heath M F. 1991. Serum fructosamine in ovine pregnancy toxaemia: a possible prognostic index. Veterinary Record 128: 525–26. DOI: https://doi.org/10.1136/vr.128.22.525

Celi P, Trana A D and Claps S. 2008. Effects of perinatal nutrition on lactational performance, metabolic and hormonal profiles of dairy goats and respective kids. Small Ruminant Research 79: 129–36. DOI: https://doi.org/10.1016/j.smallrumres.2008.07.010

Celi P, Trana A D and Claps S. 2010. Effects of plane of nutrition on oxidative stress in goats during the peripartum period. Veterinary Journal 184: 95–99. DOI: https://doi.org/10.1016/j.tvjl.2009.01.014

Deepa P M, Dimri U, Jhambh R, Yatoo M I and Sharma B. 2014. Alteration in clinico-biochemical profile and oxidative stress indices associated with hyperglycaemia with special reference to diabetes in cattle—a pilot study. Tropical Animal Health Production 47 (1): 103–09. DOI: https://doi.org/10.1007/s11250-014-0691-5

Di Trana A, Celi P, Claps S, Fedele V and Rubino R. 2006. The effect of hot season and nutrition on the oxidative status and metabolic profile in dairy goats during mid lactation. Animal Science 82: 717–22. DOI: https://doi.org/10.1079/ASC200672

Filipoviæ N, Stojeviæ Z, Mašek T, Mikulec • and Prvanoviæ N. 2011. Relationship between fructosamine with serum protein, albumin and glucose concentrations in dairy ewes. Small Ruminant Research 96: 46–48. DOI: https://doi.org/10.1016/j.smallrumres.2010.11.003

Finco D R. 1997. Kidney function. Clinical Biochemistry of Domestic Animals. 5th edn. Pp. 485–516. (Eds) Kaneko J J, Harvey J W and Bruss M L. Academic Press Inc, San Diego.

Hiliman R E. 1978. Simple, rapid method for determination of propionic acid and other short chain fatty acids in serum. Clinical Chemistry 24: 800–03. DOI: https://doi.org/10.1093/clinchem/24.5.800

Hussein S A and Azab M E. 1998. Plasma concentrations of lipids and lipoproteins in newborn kids and female Baladi goats during late pregnancy and onset of lactation. Dtsch Tierarztl Wochenschr 105: 6–9.

Kaneko J J, Harvey J W and Bruss M L. 1997. Clinical Biochemistry of Domestic Animals. Academic Press, Inc., New York.

Kannan G, Kouakou B, Terrill T H and Gelaye S. 2003. Endocrine, blood metabolite, and meat quality changes in goats as influenced by short-term, preslaughter stress. Journal of Animal Science 81: 1499–507. DOI: https://doi.org/10.2527/2003.8161499x

Khan J R and Ludri R S. 2002a. Changes in blood glucose, plasma non-esterified fatty acids and insulin in pregnant and non- pregnant goats. Tropical Animal Health Production 34: 81– 90. DOI: https://doi.org/10.1023/A:1013798114081

Khan J R and Ludri R S. 2002b. Hormone profile of crossbred goats during the periparturient period. Tropical Animal Health Production 34: 151–62. DOI: https://doi.org/10.1023/A:1014270207145

Madesh M and Balasubramanian K A. 1998. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian Journal of Biochemistry Biophysics 35 (3): 184–88.

Magistrelli D and Rosi F. 2014. Trend analysis of plasma insulin level around parturition in relation to parity in Saanen goats. Journal of Animal Science 92: 2440–46. DOI: https://doi.org/10.2527/jas.2013-6993

Mbassa G K and Poulsen J S. 1991a. Influence of pregnancy, lactation and environment on some clinical chemical reference values in Danish landrace dairy goats (Capra hircus) of different parity—II. Plasma urea, creatinine, bilirubin, cholesterol, glucose and total serum proteins. Comparative Biochemistry Physiology B 100: 423–31. DOI: https://doi.org/10.1016/0305-0491(91)90396-U

Mbassa G K and Poulsen J S. 1991b. Influence of pregnancy, lactation and environment on haematological profiles in Danish landrace dairy goats (Capra hircus) of different parity. Comparative Biochemistry Physiology B 100: 403–12. DOI: https://doi.org/10.1016/0305-0491(91)90394-S

Mbassa G K and Poulsen J S. 1991c. Influence of pregnancy, lactation and environment on some clinical chemical reference values in Danish landrace dairy goats (Capra hircus) of different parity-I. Electrolytes and enzymes. Comparative Biochemistry Physiology B 100: 413–22. DOI: https://doi.org/10.1016/0305-0491(91)90395-T

Mbassa G K and Poulsen J S. 1991d. Profiles of some clinical chemical parameters in growing dwarf and landrace kids. Zentralbl Veterinarmed A 38: 676–90. DOI: https://doi.org/10.1111/j.1439-0442.1991.tb01064.x

Misra R K, Singh B and Jain V K. 1998. Breed characteristics of Changthangi pashmina goat. Small Ruminant Research 27: 97– 102. DOI: https://doi.org/10.1016/S0921-4488(97)00033-3

Pedernera M, Celi P, García S C, Salvin H E, Barchia I and Fulkerson W J. 2010. Effect of diet, energy balance and milk production on oxidative stress in early-lactating dairy cows grazing pasture. Veterinary Journal 186: 352–57. DOI: https://doi.org/10.1016/j.tvjl.2009.09.003

Placer Z. 1967. Lipo peroxydations systems von Sub zellular partikeln. Nahrung 11: 623– 27. DOI: https://doi.org/10.1002/food.19670110710

Price C P, Lloyd B and Alberti G M. 1977. A kinetic spectrophotometric assay for rapid determination of acetoacetate in blood. Clinical Chemistry 23: 1893–97. DOI: https://doi.org/10.1093/clinchem/23.10.1893

Prins H K and Loos J A. 1969. Biochemical Methods in Red Cell Genetics. Academic Press, London, UK. 530.

Sahu A and Sarkar P D. 2008. Comparative study of NBT reduction method for estimation of glycated protein (serum fructosamine) with glycated HbA1c estimated on DCA 2000 analyzer. Indian Journal of Physiology and Pharmacology 52 (4): 408–412.

Singh M and Ludri R S. 2002. Milk production, blood metabolites and circulatory levels of hormones in crossbred goats. Asian Australasian Journal of Animal Science 15: 963–67. DOI: https://doi.org/10.5713/ajas.2002.963

Singh A K, Ghosh S, Basu P and Haldar C. 2014. Daily variation in melatonin level, antioxidant activity and general immune response of peripheral blood mononuclear cells and lymphoid tissues of Indian goat Capra hircus during summer and winter. Indian Journal of Experimental Biology 52: 467–77.

Solaiman S, Min B R, Gurung N, Behrends J and McElhenney W. 2012. Effects of breed and harvest age on feed intake, growth, carcass traits, blood metabolites and lipogenic gene expression in Boer and Kiko goats. Journal of Animal Science 90: 2092–108. DOI: https://doi.org/10.2527/jas.2011-3945

Somvanshi R, Biswas J C, Sharma B and Koul G L. 1987. Haematological studies on Indian pashmina goats. Research in Veterinary Science 42: 124–26. DOI: https://doi.org/10.1016/S0034-5288(18)30667-2

Trivelli L A, Ranney H A and Lai H T. 1971. Haemoglobin components in patients with diabetes mellitus. New England Journal of Medicine 284: 353–57. DOI: https://doi.org/10.1056/NEJM197102182840703

Yatoo M I, Singh M, Kubrevi S S, Shabir M, Dar R and Angmo K. 2014a. Safeguarding a national asset: A review on problems faced by Pashmina farmers in Changthang and their amelioration. Indian Journal of Animal Science 84: 1251–55.

Yatoo M I, Kumar P, Dimri U, Sharma M C. 2014b. Evaluation of serum thyroid hormone concentration in growing lambs and kids. Indian Veterinary Journal 91(6): 78–79.

Yatoo M I, Dimri U and Sharma M C. 2014c. Seasonal changes in certain blood antioxidants in cattle and buffaloes. Indian Journal of Animal Science 84 (2): 75–79.

Zarei M A, Farshad A, Akhondzadeh S. 2009. Variations in thyroidal activity during estrous cycle and natural breeding season in markhoz goat breeds. Pakistan Journal of Biological Science 12: 1420–24. DOI: https://doi.org/10.3923/pjbs.2009.1420.1424