Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats
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Keywords:
Bioavailability, Goats, Intramuscular, Ofloxacin, SubcutaneousAbstract
Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of drug administration and peaked at 1 h. t1/2ka and t1/2β values were 13.59 and 78.41 min after i.m. administration while 17.89 and 103.59 min after s.c. administration and the corresponding bioavailability values were 75.43±5.00 and 102.07±7.00 %. Ofloxacin may be adiministered to goat @10 mg/kg at 12 h interval by s.c. route.
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References
Baggot J D. 1977. Principles of drug disposition in domestic animals. The Basis of Veterinary Clinical Pharmacology.1st edn. W.B. Saunders Co., Philadelphia, USA.
Baruah H, Roy D C, Roy R K and Khonikor H N. 2004. Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats. Journal of Veterinary Science (5): 97– 101. DOI: https://doi.org/10.4142/jvs.2004.5.2.97
Dudley M N. 1991. Pharmacodynamics and pharmacokinetics of antibiotics with special reference to the fluoroquinolones. American Journal of Medicine (91): 45S-50S. DOI: https://doi.org/10.1016/0002-9343(91)90311-K
Gao X X, Yao G C, Guo N, An F and Guo X J. 2007. A simple and rapid high performance liquid chromatography method to determine levofloxacin in human plasma and its use in a bioequivalence study. Drug Discovery and Therapeutics (1): 136–40.
Gaur A, Garg S K and Saini S P. 2005. Comparative disposition kinetics of ofloxacin following a single i.m. and s.c. administration in neonatal calves. Journal of Veterinary Pharmacology and Therapeutics (28): 485–88. DOI: https://doi.org/10.1111/j.1365-2885.2005.00687.x
Gaur A, Saini S P S, Garg S K, Chaudhary R K and Srivastava A K. 2004. Pharmacokinetics of ofloxacin after a single intravenous bolus dose in neonatal calves. Journal of Veterinary Pharmacology and Therapeutics (27): 115–17. DOI: https://doi.org/10.1111/j.1365-2885.2004.00493.x
Greene C E and Budsberg S C. 1993. Veterinary Use of Quinolones, Quinolone Antimicrobial Agents. 2nd edn, pp. 473–88.
(Eds) Hooper D C and Wolfson J S. American Society of Microbiology, Washington D C, USA.
Hooper D C. 2000. Quinolones, Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 5th edn, pp. 404–23.(Eds) Mandell G L, Bennett J E, Dolin R. Churchill Livingstone, Philadelphia, New York.
Intorre L, Mengozzi G, Bertini S, Bagliacca M, Luchetti E and Soldani G. 1997. The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the Muscovy duck. Veterinary Research Communication (21): 127–36. DOI: https://doi.org/10.1023/A:1005773603905
Karlowsky J A, Kelly L J, Thornsberry C, Jones M E, Evangelista A T, Critchley I A and Sahm D F. 2002. Susceptibility to fluoroiquinolones among commonly isolated gram negative bacilli in 2000: TRUST and TSN data for the United States. Tracking resistance in the United States today. The surveillance network. International Journal of Antimicrobial Agents (19): 21–31. DOI: https://doi.org/10.1016/S0924-8579(01)00466-6
Kumar S, Punia J S and Jain S K. 2009. Disposition kinetics and urinary excretion of ofloxacin following intramuscular administration in buffalo calves. Buffalo Bulletin (28): 154– 58.
Mckellar Q A. 1996. Clinical relevance of the pharmacological properties of fluoroquinolones. Compendium on Continuing Education for the Practicing Veterinarian (18): 14–21.
Nielsen P and Gyrd-Hansen N. 1997. Bioavailability of enrofloxacin after oral administration to fed and fasted pigs. Pharmacology and Toxicology (80): 246–50. DOI: https://doi.org/10.1111/j.1600-0773.1997.tb01967.x
Renneberg J and Walder M. 1989. Postantibiotic effects of imipenem, norfloxacin and amikacin in vitro and in vivo. Antimicrobial Agents and Chemotherapy (33): 1714–20. DOI: https://doi.org/10.1128/AAC.33.10.1714
Son D S, Ikenoue N, Tagawa Y, Shimoda M and Kokue E. 2000. Non-linear phamacokinetics of ofloxacin after a single intravenous bolus dose in pigs. Journal of Veterinary Pharmacology and Therapeutics (23): 311–15. DOI: https://doi.org/10.1046/j.1365-2885.2000.00289.x
Yoshida K, Yabe K, Nishida S, Yamamoto N, Ohshima C, Sekiguchi M, Yamada K and Furuhama K. 1998. Pharmacokinetic disposition and arthropathic potential of oral ofloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics (21): 128–32. DOI: https://doi.org/10.1046/j.1365-2885.1998.00114.x
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