Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats


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Authors

  • RAJKUMAR SINGH YADAV UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya evam Go- Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh 281 001 India
  • SATISH KUMAR GARG UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya evam Go- Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh 281 001 India

https://doi.org/10.56093/ijans.v86i7.59884

Keywords:

Bioavailability, Goats, Intramuscular, Ofloxacin, Subcutaneous

Abstract

Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of drug administration and peaked at 1 h. t1/2ka and t1/2β values were 13.59 and 78.41 min after i.m. administration while 17.89 and 103.59 min after s.c. administration and the corresponding bioavailability values were 75.43±5.00 and 102.07±7.00 %. Ofloxacin may be adiministered to goat @10 mg/kg at 12 h interval by s.c. route.

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Submitted

2016-07-13

Published

2016-07-15

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Short-Communication

How to Cite

YADAV, R. S., & GARG, S. K. (2016). Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats. The Indian Journal of Animal Sciences, 86(7), 764–766. https://doi.org/10.56093/ijans.v86i7.59884
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