Prevalence of genetic diseases in Holstein crossbred (Frieswal) bulls in India

RAFEEQUE R ALYETHODI; RANI ALEX; RAJIB DEB; SUSHIL KUMAR; UMESH SINGH; SHEETAL SHARMA; GYANENDRA SENGAR; S TYAGI; B PRAKASH

doi:10.56093/ijans.v86i9.61589

Authors

RAFEEQUE R ALYETHODI ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
RANI ALEX ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
RAJIB DEB ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
SUSHIL KUMAR ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
UMESH SINGH ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
SHEETAL SHARMA ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
GYANENDRA SENGAR ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
S TYAGI ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
B PRAKASH ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India

https://doi.org/10.56093/ijans.v86i9.61589

Keywords:

BLAD, BC, DUMPS, FXID, Frieswal, PCR-RFLP

Abstract

The present study was conducted to assess the prevalence of genetic diseases, viz. BLAD, DUMPS, BC and FXID in Frieswal (Sahiwal × HF) young bulls. We used the standard PCR-RFLP method to genotype animals for BLAD, DUMPS and BC while simple PCR was done to genotype FXID. The identified BLAD carriers were further verified by sequencing. A carrier prevalence of 4.6 % was noticed for BLAD in Frieswal young bulls while no carriers were identified for other genetic diseases. Pedigree analysis revealed that imported semen of Holstein Friesian bull Valeriant may be the source for the spread the BLAD in Indian Frieswal herd. The present study indicates the existence of BLAD carrier animals in Frieswal bull calves eventhough at a relatively low frequency. Hence it is recommended to screen young bulls at early stages for these defective genes in order to avoid spread within the population.

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