Demonstration of foot-and-mouth disease virus infection specific non-structural protein-antibodies in a vaccinated herd comprising cattle, buffaloes and goats in north India

MANORANJAN ROUT; MANAS RANJAN SENAPATI; JAJATI KESHARI MOHAPATRA; TUSHAR KUMAR MOHANTY; SHIV PRASAD KIMOTHI; ANIKET SANYAL

doi:10.56093/ijans.v86i11.62984

Authors

MANORANJAN ROUT ICAR-Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar, Uttarakhand 263 138 India
MANAS RANJAN SENAPATI Orissa University of Agriculture and Technology, Odisha
JAJATI KESHARI MOHAPATRA ICAR-Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar, Uttarakhand 263 138 India
TUSHAR KUMAR MOHANTY Artificial Breeding Research Center, ICAR-NDRI, Karnal
SHIV PRASAD KIMOTHI Indian Council of Agricultural Research, Krishi Bhawan, New Delhi
ANIKET SANYAL Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru

https://doi.org/10.56093/ijans.v86i11.62984

Keywords:

Foot-and-mouth disease virus, Liquid phase blocking ELISA, North India, NSP ELISA, Serosurveillance, Vaccinated herd

Abstract

A serological study employing 3AB3 non-structural protein ELISA and liquid phase blocking ELISA to assess foot-and-mouth disease virus (FMDV) non-structural and structural protein antibodies (NSP- and SP-Ab) was undertaken through sampling from all resident animals of a vaccinated herd comprising 943, 377 and 211 cattle, buffaloes and goats, respectively, in north India. A considerable, though disparate proportions of animals (61.2% cattle, 29.2% buffaloes and 29.9% goats) were positive for NSP-Ab suggesting an exposure to FMDV. From the age-stratified analysis of NSP-Ab prevalence, the probable time point of virus introduction in the farm could be predicted in retrospect to be around 8 months before sampling. The proportion of animals showing ≥1.8 log₁₀ titre against all 3 serotypes in the vaccine varied from 3.2 to 32.9% in different species indicating poor vaccinal herd immunity, which presumably might have been the reason for the outbreak in the farm.

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References

Annual Report, PDFMD. 2014–2015. Project Directorate on Foot and Mouth Disease, Mukteswar, Nainital, India.

Huang C C, Lee F, Tu W J, Lee S H, Huang T S, Lin Y L, Jong M H and Lin S Y. 2002. Anti-3AB antibodies in the Chinese yellow cattle infected by the O/Taiwan/99 foot- and-mouth disease virus. Veterinary Microbiology 84: 317– 26. DOI: https://doi.org/10.1016/S0378-1135(01)00471-0

Kitching R P. 2002. Clinical variation in foot and mouth disease: cattle. Revue Scientifique Et Technique (International Office of Epizootics) 21: 499–504. DOI: https://doi.org/10.20506/rst.21.3.1343

Mohapatra J K, Pandey L K, Sanyal A and Pattnaik B. 2011. Recombinant non-structural polyprotein 3AB-based serodiagnostic strategy for FMD surveillance in bovines irrespective of vaccination. Journal of Virological Methods 177: 184–92. DOI: https://doi.org/10.1016/j.jviromet.2011.08.006

Niewiesk S. 2014. Maternal antibodies: clinical significance, mechanism of interference with immune responses and possible vaccination strategies. Frontiers of Immunology 5: 446. DOI: https://doi.org/10.3389/fimmu.2014.00446

Paton D J, Füssel A E, Vosloo W, Dekker A and De Clercq K. 2014. The use of serosurveys following emergency vaccination, to recover the status of “foot-and-mouth disease free where vaccination is not practiced”. Vaccine 32: 7050– 56. DOI: https://doi.org/10.1016/j.vaccine.2014.10.064

Ranabijuli S, Mohapatra J K, Pandey L K, Rout M, Sanyal A, Dash B B, Sarangi L N, Panda H K and Pattnaik B. 2010. Serological evidence of foot and mouth disease infection in randomly surveyed goat population of Orissa, India. Transboundary and Emerging Diseases 57: 448–54. DOI: https://doi.org/10.1111/j.1865-1682.2010.01161.x

Rout M, Senapati M R, Mohapatra J K, Dash B B, Sanyal A and Pattnaik B. 2014. Serosurveillance of foot-and-mouth disease in sheep and goat population of India. Preventive Veterinary Medicine 113: 273–77. DOI: https://doi.org/10.1016/j.prevetmed.2013.10.022

Sayers R G, Byrne N, O’Doherty E and Arkins S. 2015. Prevalence of exposure to bovine viral diarrhoea virus (BVDV) and bovine herpesvirus–1 (BoHV–1) in Irish dairy herds. Research in Veterinary Science 100: 21–30. DOI: https://doi.org/10.1016/j.rvsc.2015.02.011

Weaver G V, Domenech J, Thiermann A R and Karesh W B. 2013. Foot and mouth disease: a look from the wild side. Journal of Wildlife Diseases 49: 759–85. DOI: https://doi.org/10.7589/2012-11-276