Constitutive expression pattern of ITGB6 receptor gene in the air pathways of buffalo

RANI SINGH; RAJIB DEB; UMESH SINGH; SUSHIL KUMAR; RANI ALEX; SHRIKANT TYAGI; T V RAJA; RAFEEQUE RAHMAN ALYETHODI; GYANENDRA SENGAR; SHEETAL SHARMA; V BHANUPRAKASH; ANKUR SHARMA

doi:10.56093/ijans.v86i12.65988

Authors

RANI SINGH ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
RAJIB DEB ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
UMESH SINGH ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
SUSHIL KUMAR ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
RANI ALEX ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
SHRIKANT TYAGI ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
T V RAJA ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
RAFEEQUE RAHMAN ALYETHODI ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
GYANENDRA SENGAR ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
SHEETAL SHARMA ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India
V BHANUPRAKASH ICAR-IVRI, New Delhi
ANKUR SHARMA ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh 250 001 India

https://doi.org/10.56093/ijans.v86i12.65988

Keywords:

Buffalo, Expression, ITGB6

Abstract

Integrin beta 6 (ITGB6) is one of the important integrin family proteins, required for viral entry in their respective host. The constitutive expression of ITGB6 was reported in cattle and sheep but not in buffalo. The present study is first of its kind to characterize the constitutive expression pattern of ITGB6 in the air pathways of buffalo (Bubalus bubalis). In the present study, we characterized the constitutive expression pattern of ITGB6 in the air pathways of buffalo. Our data demonstrated that mRNA transcript and concentration of ITGB6 are significantly higher in tongue tissues compared to trachea, bronchi and lung. The study may highlight that oral mucosa of buffalo are enriched with integrin receptor genes, which are the target of certain viral entry site.

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