Single nucleotide polymorphism (SNP) analysis of ovine progesterone receptor gene in Malpura ewes
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Authors
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RAJIV KUMAR
ICAR-Central Sheep and Wool Research Institute, Avikanagar, Rajasthan 304 501 India
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S K SANKHYAN
ICAR-Central Sheep and Wool Research Institute, Avikanagar, Rajasthan 304 501 India
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A K SINGH
ICAR-Central Sheep and Wool Research Institute, Avikanagar, Rajasthan 304 501 India
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B KRISHNAPPA
ICAR-Central Sheep and Wool Research Institute, Avikanagar, Rajasthan 304 501 India
Keywords:
Malpura sheep, Progesterone receptor gene, Repeat breeding, SNPsAbstract
In the present work, nucleotide sequences of progesterone receptor gene (627 bp fragments) encompassing partial ligand binding domain from repeat breeder Malpura ewes were analyzed for presence of SNPs and its association with repeat breeding. A total of 40 sequences were aligned and 13 SNPs were noted mostly in intronic region. Two novel missense mutations were observed in the ligand binding domain where histidine (H) was replaced with tyrosine (Y). These SNPs were not associated with repeat breeding in Malpura ewes.
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References
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