In-vivo biocompatibility evaluation of cross linked cellular and acellular bovine pericardium


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Authors

  • HONJON PERME
  • A K SHARMA
  • NAVEEN KUMAR
  • HIMANI SINGH
  • S K MAITI
  • RAJENDRA SINGH

https://doi.org/10.56093/ijans.v79i7.76371

Keywords:

Bovine pericardium, Biocompatibility, Histopathology, Rabbits

Abstract

Fresh bovine pericardium from the local abattoir was cut into 2 cm x 2 cm size pieces and crosslinked with 1% solution of glutaraldehyde (GA), formaldehyde (FA), polyethylene glycol (PEG), hexamethylene di-isocyanate (HMDI) and 1-ethly-3-(3-dimethylaminoprophl)-carbodiimide (EDC). Other pieces were made acellular and then crosslinked with above chemical agents. In-vivo biocompatibility of the biomaterials was determined by subcutaneous implantation in rabbits. The implants were retrieved back on day 14, 30 and 90 post-implantation and subjected to macroscopic and microscopic evaluation. The host inflammatory response, neovasular tissue formation (fibroblasts, fine capillaries), depostition of neocollagen and penetration of host inflammatory responses in the grafted matrix were evaluated.

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Author Biographies

  • HONJON PERME

    Ph.D. Scholar, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India

  • A K SHARMA
    Principal Scientist,  Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • NAVEEN KUMAR
    Principal Scientist,  Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • HIMANI SINGH
    Junior Research Fellow, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India
  • S K MAITI

    Senior Scientist, Division of Surgery,  Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India

  • RAJENDRA SINGH
    Principal Scientist, CADRAD,  Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India

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Submitted

2017-12-07

Published

2024-05-29

Issue

Section

Articles

How to Cite

PERME, H., SHARMA, A. K., KUMAR, N., SINGH, H., MAITI, S. K., & SINGH, R. (2024). In-vivo biocompatibility evaluation of cross linked cellular and acellular bovine pericardium. The Indian Journal of Animal Sciences, 79(7). https://doi.org/10.56093/ijans.v79i7.76371
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