Comparison of calcium absorption from nano- and micro-sized calcium salts using everted gut sac technique


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Authors

  • RAKESH RANJAN Senior Scientist, ICAR-National Research Centre on Camel, Jorbeer, Bikaner, Rajasthan 334 001 India
  • R K SAWAL Principal Scientist, ICAR-National Research Centre on Camel, Jorbeer, Bikaner, Rajasthan 334 001 India
  • AMITA RANJAN Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan
  • N V PATIL Director, ICAR-National Research Centre on Camel, Jorbeer, Bikaner, Rajasthan 334 001 India

https://doi.org/10.56093/ijans.v89i3.88101

Keywords:

Absorption, Calcium, Nanoparticles, Poultry, Everted gut sac

Abstract

The present study aimed to compare the calcium absorption from calcium carbonate and calcium phosphate in nano and micro-sized forms using everted gut sac technique. It was found that calcium concentrations in sac fluid were higher after incubation in nano-sized calcium carbonate than micro-sized calcium carbonate by 18.23% at 45 min and 21.39% at 75 min. Likewise, Ca concentration in sac fluid was 20.50 and 15.13% higher in nano-sized calcium phosphate than those incubated in micro-sized forms at 45 and 75 min, respectively. Present study revealed that calcium carbonate and calcium phosphate are more extensively absorbed in nano-sized forms than in microsized forms, suggesting their possible use as calcium supplements in poultry and livestock farming.

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References

Alam M A, Al-Jenoobi F I and Al-mohizea A M. 2012. Everted gut sac model as a tool in pharmaceutical research: limitations and applications. Journal of Pharmacy and Pharmacology 64: 326–36. DOI: https://doi.org/10.1111/j.2042-7158.2011.01391.x

Couvreur P and Vauthier C. 2006. Nanotechnology: intelligent design to treat complex disease. Pharmaceutical Research 23: 1417–50. DOI: https://doi.org/10.1007/s11095-006-0284-8

Erfanian A, Mirhosseini H, Manap M Y A, Rasti B and Bejo MH. 2014. Influence of nano-size reduction on absorption and bioavailability of calcium from fortified milk powders in rats. Food Research International 66: 1–11. DOI: https://doi.org/10.1016/j.foodres.2014.08.026

Hanzlik R P, Fowler S C and Fisher D H. 2005. Relative bioavailability of calcium from calcium formate, calcium citrate and calcium carbonate. The Journal of Pharmacology and Experimental Therapeutics 313: 1217–22. DOI: https://doi.org/10.1124/jpet.104.081893

Hassim A and Rachmawati H. 2010. Preparation and characterization of calcium carbonate nanoparticles. In: Proceedings of the 3rd Nanoscience and Nanotechnology Symposium, Bandung, Indonesia. DOI: https://doi.org/10.1063/1.3515549

He Q, Mitchell A R, Johnson S L, Bartak C W, Morcol T and Bell S J D. 2000. Calcium phosphate nanoparticle adjuvant. Clinical and Diagnostic Laboratory Immunology 7: 899–903. DOI: https://doi.org/10.1128/CDLI.7.6.899-903.2000

Huang S, Chen J C, Hsu C W and Chang W H. 2009. Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology 20: 375102–08. DOI: https://doi.org/10.1088/0957-4484/20/37/375102

Jeong A L, Kim M K, Kim H M, Lee J K, Kim Y R, Oh J M and Choi S J. 2015. The fate of calcium carbonate nanoparticles administered by oral route; absorption and their interaction with biological matrices. International Journal of Nanomedicine 10: 2273–93. DOI: https://doi.org/10.2147/IJN.S79403

Kim M K, Lee J A, Jo M R, Kim M K, Kim H M, Oh J M, Song NW and Choi S J. 2015. Cytotoxicity, uptake behaviors, and oral absorption of food grade calcium carbonate nanomaterials. Nanomaterials (Basel) 5: 1938–54. DOI: https://doi.org/10.3390/nano5041938

Radostits O M, Gay C C, Blood D C and Hinchcliff K W. 2000. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses, 9th ed. W B Saunders Company Ltd, London.

Ranjan R, Narnaware S D and Patil N V. 2018. A novel technique for synthesis of calcium carbonate nanoparticles. National Academy of Science Letters 41(6): 403–06. DOI: https://doi.org/10.1007/s40009-018-0704-4

Swain P S, Rajendran D, Rao S B N and Dominic G. 2015. Preparation and effects of nano mineral particle feeding in livestock: A review. Veterinary World 8: 888–91. DOI: https://doi.org/10.14202/vetworld.2015.888-891

Thilsing-Hansen T, Jorgensen R J and Ostergaard S. 2002. Milk fever control principles: A review. Acta Veterinaria Scandinavia 43: 1–19. DOI: https://doi.org/10.1186/1751-0147-43-1

Vijaykumar M P and Balakrishnan V. 2014. Effect of calcium phosphate nanoparticles supplementation on growth performance of broiler chicken. Indian Journal of Science and Technology 7: 1149–54. DOI: https://doi.org/10.17485/ijst/2014/v7i8.20

Yang R S, Liu R K and Tsai K S. 1994. The acute metabolic effects of oral tricalcium phosphate and calcium carbonate. Calcified Tissue International 55: 335–41. DOI: https://doi.org/10.1007/BF00299310

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Submitted

2019-03-22

Published

2019-03-22

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Short-Communication

How to Cite

RANJAN, R., SAWAL, R. K., RANJAN, A., & PATIL, N. V. (2019). Comparison of calcium absorption from nano- and micro-sized calcium salts using everted gut sac technique. The Indian Journal of Animal Sciences, 89(3), 337–339. https://doi.org/10.56093/ijans.v89i3.88101
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