A NOVEL THERAPEUTIC COMBINATION OF VINCRISTINE AND IVERMECTIN IN THE TREATMENT OF TRANSMISSIBLE VENEREAL TUMOUR IN BITCHES

R. Sree Hari Reddy; M. Srinivas; K. Sunny Praveen

doi:10.56093/ijvasr.v51i3.127460

Authors

R. Sree Hari Reddy PG Student, Department of Veterinary Gynaecology and Obstetrics, NTR College of Veterinary Science, Gannavaram, SVVU, Andhra Pradesh
M. Srinivas Professor and Head, Department of Veterinary Gynaecology and Obstetrics, NTR College of Veterinary Science, Gannavaram, SVVU, Andhra Pradesh
K. Sunny Praveen Assistant Professor, Department of Veterinary Gynaecology and Obstetrics, NTR College of Veterinary Science, Gannavaram, SVVU, Andhra Pradesh

https://doi.org/10.56093/ijvasr.v51i3.127460

Keywords:

Ivermectin, Transmissible venereal tumour, Treatment, Vincristine

Abstract

The transmissible venereal tumour (TVT) is a contagious neoplasm that is sexually transmitted between dogs. TVT lesions affect the mucus membranes of the external genitalia in dogs of both sexes. Tumour masses are seen in the caudal aspect of the penis and frequently the prepuce area in males and the posterior vaginal area, particularly the vestibule vaginal junction of females. Sixteen bitches of various ages (2-6 years) and breeds were brought to the clinics at Veterinary Clinical Complex, Gannavaram with the history of continuous oozing of blood from vagina, anorexia and depression. All these were diagnosed as TVT based on the history, clinical symptoms and cytological examination and therapy was initiated. At weekly intervals, all the bitches were administered with combination therapy of Vincristine sulphate (0.025 mg/kg body weight, strict and slow I/V) and Ivermectin (0.2 mg/kg body weight, strict S/C) for four consecutive weeks. All of the bitches underwent significant reduction in tumour size with improvement in general health during the course of therapy with exception that one bitch showed signs of anorexia and dullness.

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