Immunogenicity of pasteurella multocida cell associated and  cell free antigens in mice

Sahzad; S. Arya; M. Bora; S. Shebannavar; T. V. S. Rao; G. S. Reddy

doi:10.56093/ijvasr.v48i1.130405

Authors

Sahzad Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana
S. Arya Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana
M. Bora Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana
S. Shebannavar Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana
T. V. S. Rao Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana
G. S. Reddy Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad - 502 307, Telangana

https://doi.org/10.56093/ijvasr.v48i1.130405

Keywords:

Haemorrhagic septicaemia, Pasteurella multocida, Cattle, Vaccines, Cell free antigen, Cell associated antigen

Abstract

Haemorrhagic septicaemia is an economically important contagious disease of cattle, buffaloes and bison. In the present study, the efficacy of the vaccines prepared from cell free and cell associated antigens of disease causing organism Pasteurella multocida was
evaluated in mice. From the present study, it was observed that both cell associated and cell free antigens provided protective immunity to the vaccinated animals in combination with each other and increasing the content of both the antigens improved the efficacy of the vaccine blends. In conclusion, use of both cell associated and cell free antigens in vaccine formulations are warranted for developing improved vaccines against Haemorrhagic septicaemia.

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