Plasma taurine estimation in dilated cardiomyopathy of labrador retrievers

K. Jeyaraja; G. Sarath Chandra; Hamsa Yamini; P.S. Thirunavukkarasu

doi:10.56093/ijvasr.v46i3.138796

Authors

K. Jeyaraja Associate Professor, Department of Clinics, Madras Veterinary College, TANUVAS, Chennai - 600 007
G. Sarath Chandra Professor and Head, Pharmacovigilance Laboratory for Animal Feed and Food Safe, Directorate of Centre for Animal Health Studies, MMC, TANUVAS, Chennai - 51
Hamsa Yamini Ph.D. Scholar, Department of veterinary Clinical Medicine, Madras Veterinary College, TANUVAS, Chennai - 600 007
P.S. Thirunavukkarasu Professor and Head, Department of Preventive Medicine, Madras Veterinary College, TANUVAS, Chennai - 600 007

https://doi.org/10.56093/ijvasr.v46i3.138796

Abstract

The objective of this study was to quantify the concentrations of taurine in the plasma of Labrador retrievers with clinical disease of Dilated Cardiomyopathy (DCM) and to compare with the healthy Labrador retrievers. The study was conducted in thirty clinical cases of Dilated cardiomyopathy (DCM) in Labrador Retrievers and in thirty healthy Labradors. The plasma taurine estimation by HPLC showed a highly significant decrease in taurine levels (18.712 ± 3.53 nmol/mL) in dogs with Dilated cardiomyopathy compared to healthy dogs (51.022 ± 5.55 nmol/mL). Therefore, it was concluded that there was a significant role of plasma taurine in the pathogenesis of Dilated cardiomopathy in Labrador Retrievers . This pilot study justifies the supplementation of taurine in DCM of Labradors and also it opened up a new area for extensive research at a larger scale involving multi centres. In addition a commercially viable method for estimation of taurine was developed.

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References

Atkins, C.E., and Snyder, P.S. (1992). Systolic time intervals and their derivatives for evaluation of cardiac function. Journal of Veterinary Internal Medicine, 6: 55–63.

Backus, R.C., Ko, K.S.,Fascetti, A.J.,Kittleson, M.D., Macdonald, K.A., Maggs, D.J., Berg, J.R. and Rogers, Q.R.J.(2006). Low plasma taurine concentration in Newfoundland dogs is associated with low plasma methionine and cyst(e)ine concentrations and low taurine synthesis. Journal of Nutrition, 136(10): 2525 - 2533.

Bélanger, M.C., Ouellet, M.,Queney, G. and Moreau, M.(2005). Taurine-deficient dilated cardiomyopathy in a family of golden retrievers. Journal of the American Animal Hospital Association, 41(5): 284-291.

Boon, J.A. (1995). In: Manual of Veterinary Echocardiography, Williams and Wilkinson, Baltimore. Pp.478.

Borgarelli, M., Santilli, R.S., Chiavegato, D., D’Agnolo, G., Zanatta, R., Mannelli A. and Tarducci, A. (2006). Prognostic indicators for dogs with dilated cardiomyopathy. Journal of Veterinary Internal Medicine, 20: 104-110.

Buchanan, J.W., and Bucheler, J. (1995). Vertebral scale system to measure canine heart size in radiographs. Journal of American Veterinary Medical Association, 206(2): 194-199.

Calvert, C. A., Chapman, W.L. and Toal, R.L. (1982). Congestive cardiomyopathy in Doberman Pinscher dogs. Journal of the American Veterinary Medical Association, 181: 598–602.

Cobb.M.A. (1992). Idiopathic dilated cardiomyopathy: advances in aetiology, pathogenesis and management. Journal of Small Animal Practice 33: 113-118.

Delaney, S.J, Kass, P.H, Rogers, Q.R. and Fascetti, A.J. (2003). Plasma and whole blood taurine in normal dogs of varying size fed commercially prepared food. Journal of Animal Physiology and Animal Nutrition, 87(5): 263-244.

Kramer G.A, Kittleson, M.D., Fox, P.R., Lewis, J. and Pion, P.D.J. (1995). Plasma taurine concentrations in normal dogs and in dogs with heart disease.Journal of Veterinary Internal Medicine, 9(4): 253-258.

McEwan. J.D., Borgarelli, M., Tidholm, A., Vollmar, A.C. and Häggström, J. (2003). The ESVC Taskforce for Canine Dilated Cardiomyopathy. Proposed Guidelines for the Diagnosis of Canine Idiopathic Dilated Cardiomyopathy. Journal of Veterinary Cardiology, 5: 7-19.

McCurin and Poffenbarg., (1991). In: Small animal physical diagnosis and clinical procedures, Saunders, Philadelphia.

Monnet, E., Orton, C.E., Salman, M. and Boon, J.(1995). Idiopathic dilated cardiomyopathy in dogs: Survival and prognostic indicators. Journal of Veterinary Internal Medicine, 9: 12–17.

Schaffer, S., Solodushko, V., Pastukh, V., Ricci, C. and Azuma, J. (2003). Possible Cause of Taurine-deficient Cardiomyopathy: Potentiation of Angiotensin II Action. Journal of cardiovascular Pharmacology. 41(5): 751-759.

Smith, F. W. K. and Hadlock, D.J. (1995). Electrocardiography. In: Manual of canine and feline cardiology, 2nd ed. (M. S. Miller, L. P. Tilley, Eds.). W. B. Saunders. Philadelphia.

Tidholm, A. and Jönsson, L.(1996). Dilated cardiomyopathy in the New Found land: A study of 37 cases (1983–1994). Journal of the American Animal Hospital Association. 32: 465–470.