Pharmacokinetic profile of single dose intravenous administration of ceftizoxime in female mehsana goats

S. I. Bhatiya; S. K. Mody; H. B. Patel; R. D. Singh; R. R. Desai

doi:10.56093/ijvasr.v45i1.139521

Authors

S. I. Bhatiya Ph.D. Scholar, Department of Pharmacology, DUVASU, Mathura
S. K. Mody Professor and Head, Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar – 385 506, Gujarat
H. B. Patel Assistant Professor, Department of Pharmacology and Toxicology, Veterinary College, SDAU, Sardarkrushinagar, Gujarat – 385 506
R. D. Singh Assistant Professor, Department of Pharmacology and Toxicology, Veterinary College, SDAU, Sardarkrushinagar, Gujarat – 385 506
R. R. Desai PG Scholar, Department of Pharmacology and Toxicology, Veterinary College, SDAU, Sardarkrushinagar, Gujarat – 385 506

https://doi.org/10.56093/ijvasr.v45i1.139521

Keywords:

Pharmacokinetics, Ceftizoxime, Mehsana female goat, HPLC

Abstract

Ceftizoxime is the third generation cephalosporin, extensively used in veterinary medicine. It has larger volume of distribution, good penetration into tissues, and useful for the treatment of mastitis which is resistant to other antibiotics. Keeping in view of generating pharmacokinetic data of ceftizoxime in different domestic animals, the present study was planned to investigate pharmacokinetics of ceftizoxime in goats (n = 6) at the dose rate of 10mg kg^-1body weight following single dose intravenous administration. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC) with UV detector. The values of C_max, AUC and MRT were 44.40 ± 2.09 µg ml^-1, 121.22 ± 15.40µg.h.ml^-1 and 11.44 ± 1.30 h, respectively. The longer elimination half-life (8.92 ± 1.11h) along with smaller Cl_B(0.09 ± 0.01 Lh^-1 kg^-1) showed slower excretion of the drug from animal body.

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