“TOXICOPATHOLOGICAL STUDIES OF ACETYL SALICYLIC ACID (ASA) IN BROILER CHICKS”

Sunanda Pandey; Priya D. Ghodasara; Jaynudin H. Khorajiya; Vandip. D. Chauhana; D. J. Ghodasara; B. P. Joshi

doi:10.56093/ijvasr.v44i3.148125

Authors

Sunanda Pandey Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat -388 001
Priya D. Ghodasara Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388 001
Jaynudin H. Khorajiya Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat- 388 001
Vandip. D. Chauhana Department of Parasitology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388 001
D. J. Ghodasara Department of Parasitology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388 001
B. P. Joshi Department of Parasitology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat -388 001

https://doi.org/10.56093/ijvasr.v44i3.148125

Keywords:

Alkaline Phosphatase, Acetyl salicylic acid, Hyperplasia and Necrosis

Abstract

Study was undertaken to assess the effects of Acetyl salicylic acid (ASA) administration in 80 day old cobb broiler chicks which were divided in to 4 groups. ASA was administered at the dose rate of 400, 1600 and 4000 ppm orally (Group II to IV) through feed for 21 consecutive days along with distilled water as vehicle in Group I. Birds of group III and IV were slightly dull, depressed and anorectic. Slow growth rate and blood mixed faecal droppings were observed in few birds of group IV with maximum mortality of 5 %. A dose dependent reduction in body weight and feed consumption and dose dependent significant (p < 0.05) increase in kidney: body weight ratio was observed in group III and IV as compared to control. There was significant decrease in the values of AKP, PCV, TEC and Hb in group IV. Histopathological section revealed damage to the intestine, kidney and lungs. It can be concluded that ASA at very high doses i.e. 4000ppm for longer duration can cause bone damage and anemia which can lead to mortality.

Downloads

Download data is not yet available.

References

Baert, K., Croubels, S., Maes, A., Hillaert, U., Van Calenbergh, S. and De Backer, P. (2004). Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons. JVPT, 27: 123–127.

Baert, K. and De Backer, P. (2002). Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. JVPT, 25: 449–453.

Baert, K., Duchateau, L., De Boever, S., Cherlet, M. and De Backer, P. (2005). Antipyretic effect of oral sodium salicylate after an intravenous E. coli LPS injection in broiler chickens. Br. Poultry Sc., 46: 137–143.

Balog, J.M., Huff, G.R., Rath, N.C. and Huff, W.E. (2000). Effect of dietary aspirin on ascites in broilers raised in a hypobaric chamber. Poultry Sc., 79: 1101–1105.

Boulianne, M. and Hunter, D.B. (1990). Aspirin: a treatment for sudden death in turkeys. Proceedings of the 39th western poultry disease conference, sacramento, ca; PP: 89–90.

Derakhshanfar, A., Kheirandish, R., Alidadi, S. and Bidadkosh, A. (2012). Study of long effects of administration of Aspirin on bone in broiler chickens. Comp Clin. Pathol., 22: 1201-1204.

Galil, M.A.A.A. (2004). Effect of using some anti-heat stress compounds on the performance of some local breeds of chicken under hot climatic condition. Egyptian Poultry Sc., 24: 417-427.

Glick, B. (1962). Some Physiological effects of Acetylsalicylic Acid and Sodium Salicylate in the Chicken. Ohio J. Sc., 62(1): 13-17.

Hawkins, M.G. and Paul-Murphy, J. (2011). Avian analgesia. Veterinary Clinics of North America: Exotic Animal Practice, 14: 61–80.

Johnson, M. and Manuwa, A.A. (2014). Effect of Alabukun on hematological parameters, liver and kidney of male albino rats. Sc. Jr. Biochem., ISSN: 2276-6294.

Jouglar, J.Y. and Benard, G. (1992). Indications, modalités pratiques et precautions particulières d’emploie des anti-inflammatoires chez les oiseaux. Recueil de Médecine Vétérinaire Special Anti-inflammatoires, 168: 745-747.

Livingston, A. (2010). Pain and analgesia in domestic animals. Handbook of Experimental Pharmacology. 199: 159–189.

Machin, K. L. (2005). Controlling avian pain. Compendium on Continuing Education for the Practicing Veterinarian, 27: 299–308.

McDaniel, C.D. and Parker, H.M. (2004). The effects of dietary acetylsalicylic acid on heat stress infertility of broiler breeder males. Int. J. Poultry Sc., 3: 570–577.

Merchant, M.A. and Modi, D.N. (2004). Acute and chronic effects of aspirin on hematological parameters and hepatic ferritin expression in mice. Indian J. Pharmacol., 36(4): 226-230.

Miller, A.L. and Richardson, C.A. (2011). Rodent analgesia. Veterinary Clinics of North America: Exotic Animal Practice, 14: 81–92.

Mohammed, A.A. (2012). Effect of Acetyl Salicylic Acid (ASA) in Drinking Water on Productive Performance and Blood Characteristic of Layer Hens During Heat Stress. Int. J. Poultry Sc., 9(4): 382-385.

Mohan, K., Jayakumar, K., Narayanswamy, H.D., Pavithra, B.H. and Bayer Damel, M. (2012). Study of potential toxic effects of Acetylsalicylic acid upon short-term repeated oral administration in chickens. J Applied Ani. Res., 40(4): 330-335.

Murai, A., Furuse, M. and Okumura, J. (1994). Effect of dietary aspirin on laying performance and egg yolk fatty acid composition in Japanese quail. AJAS., 7(2): 217-221.

Pozniak, B., Switała, M., Bobrek, K., Graczyk, S. and Dzimira, S. (2012). Adverse effects adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers. Br. Poultry Sc., 53: 777-783.

Pozniak, B., Yuan, H., Yi, J.E., Guo, C.Z., Deng, S.J., Zhu, Yang, Y. and Switala, M. (2010). Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens. Medycyna Weterynaryjna, 66(10): 675–679.

Proudfoot, F.G. and Hulan, H.W. (1983). Effects of dietary aspirin (acetylsalicylic acid) on the incidence of sudden death syndrome and the general performance of broiler chickens. Can. J. Anim. Sci., 63: 469-471.

Toutain, P.L., Ferran, A. and Melou, A.B. (2010). Species Differences in Pharmacokinetics and Pharmacodynamics. Handbook of Experimental Pharmacology. 199: 19-48.