ANTIOXIDANT STATUS IN CURCUMIN TREATED  RATS IN EXPERIMENTAL MAMMARY CARCINOGENESIS

P. Jalantha; C. Balachandran; N. Pazhanivel

doi:10.56093/ijvasr.v43i4.153126

Authors

P. Jalantha Department of Veterinary Pathology, Madras Veterinary College, TANUVAS, Chennai – 600 007.
C. Balachandran Department of Veterinary Pathology, Madras Veterinary College, TANUVAS, Chennai – 600 007.
N. Pazhanivel Department of Veterinary Pathology, Madras Veterinary College, TANUVAS, Chennai – 600 007.

https://doi.org/10.56093/ijvasr.v43i4.153126

Keywords:

Antioxidant, curcumin, DMBA, lipid peroxidation, mammary carcinogenesis

Abstract

The present study was carried out to evaluate the effect of curcumin on lipid peroxidation and antioxidant levels in DMBA (7, 12 Diemthyl Benanthracene) induced mammary carcinogenesis in rats. Twenty four Sprague-Dawley rats were equally distributed to control, DMBA, Tamoxifen (Standard drug) and curcumin groups. DMBA group showed significant (P<0.05) increase in lipid peroxidation and antioxidants superoxide dismutase (SOD) and catalase (CAT) levels besides reduced glutathione (GSH). Whereas, curcumin and Tamoxifen treated groups did not show any significant difference in lipid peroxidation and antioxidant status when compared to the control. Selective growth advantage of tumour cells was evident in the DMBA group and curcumin was able to prevent lipid peroxidation.

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