COMPARATIVE EVALUATION OF CARDIOVASCULAR PARAMETERS OF PROPOFOL / ETOMIDATE FOR ABDOMINAL SURGERIES IN CALVES

Abstract

The calves presented with abdominal affections requiring surgical interventions were randomly divided into group I and group II with seven animals in each group.  All the animals were premedicated with dexmedetomidine at 2 µg/kg body weight, pentazocine at 1 mg/kg body weight and midazolam at 0.2 mg/kg body weight intravenously. In group I and group II, anaesthetic induction was carried out with propofol at 2 mg/kg body weight and etomidate at 0.25 mg/kg body weight intravenously, respectively. Both the groups were maintained in Isoflurane anaesthesia with modified oro-endotracheal tube. The cardiovascular parameters such as heart rate, mean arterial blood pressure, systolic and diastolic blood pressure were monitored during different stages of anaesthesia in both the groups. In both the groups, a significant decrease in heart rate was noticed after premedication and anaesthetic induction. A Significant increase was noticed in systolic blood pressure values after anaesthetic induction and 10^th minute of anaesthesia in group I and a highly significant increase was noticed after induction up to 10 minutes in group II.  A highly significant increase in diastolic blood pressure was noticed after induction and 10^th minute in group I, whereas significant increase was noticed in mean arterial pressure after induction and 15^th minute of anaesthesia in group II animals. The cardiovascular parameters recorded in the present study concluded etomidate produced better cardiovascular stability and minimal respiratory depression compared to propofol throughout the anaesthetic period.