CLINICAL MANAGEMENT OF PEMPHIGUS USING AZATHIOPRINE IN A LABRADOR RETRIEVER

Abstract

An array of autoimmune diseases that cause blisters and damage to the skin and mucous membranes is known as the pemphigus complex. It is marked by the development of autoantibodies directed towards keratinocyte adhesion molecules. Clinical signs include crusts, erosions, erythema, macules, pustules and hyperkeratosis. These lesions are typically found on the foot pad, nasal planum, ear margins and ear pinna etc. There can also be generalized lesions accompanied by  pruritus  and  alopecia.  A  five-year-old female  Labrador  was  brought  with erythematous lesions around nose, periorbital area, ears, foot pads and vulva for three days prior to presentation. Cytology revealed acantholytic cells, indicating that the problem was pemphigus. For six weeks, oral immunosuppressive azathioprine and other supportive medications like ranitidine, fexofinadine and niacinamide were recommended. The animal experienced total recovery following treatment.