Analysis of cerebrospinal fluid in recumbent cowswith different duration of recumbency

KARTHIKEYAN  BALASUBRAMANIAN; SARAVANAN  MANI; VEERASELVAM  MUTHUSAMY; BALAKRISHNAN  SINGARAM; YOGESHPRIYA  SOMU; KARTHIKA  KOPERUMSELVAN; SASIKALA  VENKATACHALAM

doi:10.56093/ijans.v96i3.176687

Authors

KARTHIKEYAN BALASUBRAMANIAN Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
SARAVANAN MANI Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
VEERASELVAM MUTHUSAMY Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
BALAKRISHNAN SINGARAM Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
YOGESHPRIYA SOMU Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
KARTHIKA KOPERUMSELVAN Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India
SASIKALA VENKATACHALAM Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051 India

https://doi.org/10.56093/ijans.v96i3.176687

Keywords:

Cow, Chronic recumbency, CSF analysis, Neuromuscular damage

Abstract

Chronic recumbency results in progressive ischemic muscle damage, systemic inflammation and disruption of blood brain barrier, leading to neuroinflammation and irreversible recumbency in dairy cows. The present study evaluated the CSF changes into recumbent cows with different duration of recumbency from January to November 2025. The recumbent cows were unresponsive to routine therapy for more than 24 hours and were grouped as 2-5 days, 6-10 days and more than 10 days of recumbency. CSF samples were analyzed for biochemical, electrolyte, lactate, bicarbonate and neuro biomarkers. CSF analysis revealed significant reductions in glucose and increased protein, CK, LDH and neuron-specific enolase, as expected in prolonged recumbency. A significant change in CSF indicated the disruption of blood brain barrier and neuroinflammation in more than 10 days of recumbency cases.

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