Cerebrospinal fluid analysis in chronic recumbent cows with different duration of recumbency

Karthikeyan Balasubramanian; Mani Saravanan; Veeraselvam Muthusamy; Balakrishnan Singaram; Yogeshpriya Somu; Karthika Koperumselvan; Sasikala Venkatachalam

doi:10.56093/ijans.v96i3.176687

Authors

Karthikeyan Balasubramanian
Mani Saravanan Dr. M. SARAVANAN, M.V.Sc., Ph.D., (Vet. Medicine) Associate Professor and Head, Department of Veterinary Medicine, Veterinary College and Research Institute, Theni, Tamil NaduPhone No: 9952845870
Veeraselvam Muthusamy
Balakrishnan Singaram
Yogeshpriya Somu
Karthika Koperumselvan
Sasikala Venkatachalam

https://doi.org/10.56093/ijans.v96i3.176687

Keywords:

Cow, chronic recumbency, neuromuscular damage, CSF analysis, NSE

Abstract

Chronic recumbency results progressive ischemic muscle damage, systemic inflammation and disruption of the blood brain barrier, leading to neuroinflammation and irreversible recumbency in dairy cows. Aim of the study was to evaluation CSFchangesin chronic recumbent cows with different duration of recumbency.The study was conducted at the Department of Veterinary Medicine and VCC, VCRI, Orathanadu, from January to November 2025. Eighteen recumbent cows unresponsive to routine therapy for more than 24 hours were grouped as 2-5 days, 6-10 days and more than 10 days of recumbency. CSF samples were analyzed for biochemical, electrolyte, lactate, bicarbonate and neurobiomarkers. CSF analysis revealed significant reductions in glucose and increased protein, CK, LDH and neuron-specific enolase, which evident in prolonged recumbency.A significant change in CSF indicates the presence of blood brain barrier disruption and neuroinflammation in more than 10 days of recumbent cows.

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Author Biographies

Karthikeyan Balasubramanian

Department of Veterinary Medicine, Veterinary College and Research Institute, Orathanadu, Tamil Nadu.
Veeraselvam Muthusamy

Assistant Professor, Department of Veterinary Medicine, Veterinary College and Research Institute, Orathanadu, Tamil Nadu
Balakrishnan Singaram

Professor and Head, Department of Veterinary Public Health and Epidemiology, Veterinary College and Research Institute, Orathanadu, Tamil Nadu.
Yogeshpriya Somu

Assistant Professor, Department of Veterinary Medicine, Veterinary College and Research Institute, Orathanadu, Tamil Nadu
Karthika Koperumselvan

Assistant Professor, Department of Veterinary Medicine, Veterinary College and Research Institute, Orathanadu, Tamil Nadu
Sasikala Venkatachalam

Associate Professor, Department of Veterinary and Animal Husbandry Economics, Veterinary College and Research Institute, Namakkal, Tamil Nadu.

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