Plasma levels and pharmacokinetics of neomycin in buffaloes (Bubalus bubalis) following its single intrauterine infusion

Abstract

The plasma levels pharmacokinetics and dosage regimen of neomycin were investigated in healthy and normal cycling buffaloes after its intrauterine administration (5 mg/kg). The drug was rapidly absorbed from the uterus. At 5 min 3.68 ± 1.01 µg.ml^-1 of neomycin was detected in plasma. The absorption and elimination half-lives were calculated to be 0.51 ± 0.19 hr and 5.87 ± 0.47 hr respectively. The apparent volume of distribution, total body clearance and bioavailability were 0.51 ± 0.02 L.kg^-1 86.7 ± 4.41ml.kg^-1 and 69 % respectively. Based Oil pharmacokinetic parameters, a satisfactory intrauterine dosage regimen of neomycin in buffaloes would be 9 mg. kg^-1 followed by 7 mg.kg-^-1 at 12 hr intervals.