Immunopathology of alphamethrin in bovine calves

Abstract

Immunopathological effects of alphamethrin, a synthetic pyrethroid, was studied in 6 crossbred male bovine calves. The results showed that the blastogenic activity of T- and β- lymphocytes reduced 48 and 40%, respectively, in alphamethrin fed calves in comparison to controls. There was significant decrease in BoCD+₄ (T- cytotoxic), brucella specific antibody titres and total Ig G and Ig M titres in alphamethrin fed calves. Alphamethrin was found to have immunosuppressive effect at a dose of 5 mg/kg b w which may lead to increased susceptibility to various diseases.