Effect of gastrin analogue, pentagastrin, on abomasal secretion and its composition during feeding and starvation in sheep

Abstract

Grosskopf abomasal fundic pouch was fitted on 10 adult crossbred karakul rams to determine the effect of different doses of pentagastrin on the volume and composition of abomasal secretion during starvation and feeding. 1M injection of pentagastrin @ 2, 4, 8, and 12 mg/kg during starvation caused significant increase in abomasal secretion, total acidity and concentrations of potassium and chloride, but decreased the pH level and sodium concentration of the juice. Administration of pentagastrin during free access to hay showed altogether different pattern, as there was significant decrease in the volume of secretion, total acidity, potassium and chloride concentrations and an increase in pH and sodium concentration compared to control level. Comparison of maximum quantitative values at different dose levels in feeding and starvation revealed that feeding, starvation and/or administration of different doses of pentagastrin had marked effect on different parameters.