Studies on the anti-inflammatory properties of Drymaria cordata leaf extract

Abstract

The anti-inflammatory effects of Drymaria cordata methanolic extract (DCME) at the doses 300 to 900 mg/kg body wt. p.o was evaluated and compared with control and standard drug - Indomethacin (10 mg/kg body wt. p.o.). Carrageenaninduced paw oedema model in rats and mice, formalin-induced paw licking in mice were used for evaluation. Antiinflammatory effect of DCME was dose dependent and comparable with the standard drug- Indomethacin in carrageenan induced paw oedema in rat and mice. In formalin-induced paw licking model, there was significant reduction in duration of paw licking in early and late phase as well. Therefore, it can be concluded that DCME possesses anti-inflammatory property which could be due to presence of flavanoids, alkaloids and steroids.