Effect of bleeding and autotransfusion on renal functions in sheep

Abstract

Sheep (8) about 1-1½ years old were randomly divided into 2 groups for the studies. Haemorrhage was induced by phlebotomy through jugular vein @ 20% and 25% of the total blood volume in sheep of groups 1 and 2 respectively. Autotransfusion was done at 4 hr after bleeding in 2 sheep of each group and renal functions were studied. Haemorrhage caused altered renal functions due to which there was fall in glomerular filtration rate thus leading to decreased excretion of urea and creatinine. This resulted in increased concentration of urea and creatinine in blood. The plasma PSP fractional clearance also showed a decline following bleeding. In the transfused animals in both groups, decrease in GFR was less on day 1 and autotransfusion corrected the cause of decreased perfusion. This helped in the early restoration of kidney functions.