Variations in liver and kidney functions after epidural use of centbucridine in dogs*

Abstract

The epidural administration of centbucridine @ 1.5 and 1.75 mg/kg body weight with and without triflupromazine or diazepam @ 2 mg/kg body weight as preanaesthetics in 6 dogs caused significant (p<0.05) increase in blood glucose between 3 to 72 hr, serum alkaline phosphatase between 6 and 48 hr and icteric index between 3 and 6 hr. Centbucridine caused insignificant rise in serum glutamic pyruvic transaminase (SGPT), blood urea nitrogen (BUN) and blood creatinine and the values remained within normal limits.