Neutralization of enterotoxins of Escherichia coli by coleonol (Forskolin) in rabbit and guineapig ileal loop models


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Authors

  • J N S YADAVA
  • SHASHI GUPTA
  • IQBAL AHMAD
  • NEERAJ VERMA
  • J S TANDON

Abstract

A crude alcoholic extract of Coleus froskohlii Briq. roots showed marked inhibitory action against Eschrichia colt toxin induced secretary response at 300 mg/100 p dose in rabbits and guncapig ileal loops. Coleonol A and B obtained by column chromatography of a henzene fraction of the aicoholic extract of Coteus froskushlu roots exhibited antisecrery (antidiarrhocal)activity at 1 mg does/loop. Coleonol-A showed nearly 79% inhibition against heat labilc LT) toxin and 67% against heat stable (ST) toxin induced secretions However, coleonol-B exhited less activity against ST (68.3%) enteroloxins as compared to the widely used antidiarrhoeal (antisecrotory) drug. Loperamide (an opiate aganist) which showed 77 and 65% inhibution against LT and ST toxins, respectively, at a similar does.

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Author Biographies

  • J N S YADAVA
    Scientist Emeritus, Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001
  • SHASHI GUPTA
    Junior Research Fellow , Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001
  • IQBAL AHMAD
    Lecturer, Institute of Agriculture, AMU, Aligarh, Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001
  • NEERAJ VERMA
    Senior Research Fellow, Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001
  • J S TANDON
    Fomerly Assistant Director, Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001

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Issue

Vol. 65 No. 11 (1995)

Section

Articles

License

The copyright of the articles published in The Indian Journal of Animal Sciences is vested with the Indian Council of Agricultural Research, which reserves the right to enter into any agreement with any organization in India or abroad, for reprography, photocopying, storage and dissemination of information. The Council has no objection to using the material, provided the information is not being utilized for commercial purposes and wherever the information is being used, proper credit is given to ICAR.

How to Cite

YADAVA, J. N. S., GUPTA, S., AHMAD, I., VERMA, N., & TANDON, J. S. (2013). Neutralization of enterotoxins of Escherichia coli by coleonol (Forskolin) in rabbit and guineapig ileal loop models. The Indian Journal of Animal Sciences, 65(11). https://epubs.icar.org.in/index.php/IJAnS/article/view/33883